Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate
Rulifson, Ingrid C, Cao, Ping, Miao, Li, Kopecky, David, Huang, Linda, White, Ryan D, Samayoa, Kim, Gardner, Jonitha, Wu, Xiaosu, Chen, Kui, Tsuruda, Trace, Homann, Oliver, Baribault, Helene, Yamane, Harvey, Carlson, Tim, Wiltzius, Jed, Li, Yang
Published in PloS one (03.02.2016)
Published in PloS one (03.02.2016)
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RNA binding motif (RBM) proteins: A novel family of apoptosis modulators?
Sutherland, Leslie C., Rintala-Maki, Nina D., White, Ryan D., Morin, Cory D.
Published in Journal of cellular biochemistry (01.01.2005)
Published in Journal of cellular biochemistry (01.01.2005)
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Discovery and Optimization of a Novel Series of N-Arylamide Oxadiazoles as Potent, Highly Selective and Orally Bioavailable Cannabinoid Receptor 2 (CB2) Agonists
Cheng, Yuan, Albrecht, Brian K, Brown, James, Buchanan, John L, Buckner, William H, DiMauro, Erin F, Emkey, Renee, Fremeau, Robert T, Harmange, Jean-Christophe, Hoffman, Beth J, Huang, Liyue, Huang, Ming, Lee, Josie Han, Lin, Fen-Fen, Martin, Matthew W, Nguyen, Hung Q, Patel, Vinod F, Tomlinson, Susan A, White, Ryan D, Xia, Xiaoyang, Hitchcock, Stephen A
Published in Journal of medicinal chemistry (28.08.2008)
Published in Journal of medicinal chemistry (28.08.2008)
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Journal Article
Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit
Hu, Essa, Tasker, Andrew, White, Ryan D, Kunz, Roxanne K, Human, Jason, Chen, Ning, Bürli, Roland, Hungate, Randall, Novak, Perry, Itano, Andrea, Zhang, Xuxia, Yu, Violeta, Nguyen, Yen, Tudor, Yanyan, Plant, Matthew, Flynn, Shaun, Xu, Yang, Meagher, Kristin L, Whittington, Douglas A, Ng, Gordon Y
Published in Journal of medicinal chemistry (12.06.2008)
Published in Journal of medicinal chemistry (12.06.2008)
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Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile
Nakajima, Ryota, Oono, Hiroyuki, Kumazawa, Keiko, Ida, Tomohide, Hirata, Jun, White, Ryan D., Min, Xiaoshan, Guzman-Perez, Angel, Wang, Zhulun, Symons, Antony, Singh, Sanjay K., Mothe, Srinivasa Reddy, Belyakov, Sergei, Chakrabarti, Anjan, Shuto, Satoshi
Published in Bioorganic & medicinal chemistry letters (15.03.2021)
Published in Bioorganic & medicinal chemistry letters (15.03.2021)
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Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis
Dhillon, Harveen, Zigman, Jeffrey M., Ye, Chianping, Lee, Charlotte E., McGovern, Robert A., Tang, Vinsee, Kenny, Christopher D., Christiansen, Lauryn M., White, Ryan D., Edelstein, Elisabeth A., Coppari, Roberto, Balthasar, Nina, Cowley, Michael A., Chua, Streamson, Elmquist, Joel K., Lowell, Bradford B.
Published in Neuron (Cambridge, Mass.) (19.01.2006)
Published in Neuron (Cambridge, Mass.) (19.01.2006)
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Inhibitors of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1): Identification of (S)‑7-(2-Fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′H‑spiro[chromeno[2,3‑b]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)
Dineen, Thomas A, Chen, Kui, Cheng, Alan C, Derakhchan, Katayoun, Epstein, Oleg, Esmay, Joel, Hickman, Dean, Kreiman, Chuck E, Marx, Isaac E, Wahl, Robert C, Wen, Paul H, Weiss, Matthew M, Whittington, Douglas A, Wood, Stephen, Fremeau, Robert T, White, Ryan D, Patel, Vinod F
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Mice lacking ghrelin receptors resist the development of diet-induced obesity
Zigman, Jeffrey M, Nakano, Yoshihide, Coppari, Roberto, Balthasar, Nina, Marcus, Jacob N, Lee, Charlotte E, Jones, Juli E, Deysher, Amy E, Waxman, Amanda R, White, Ryan D, Williams, Todd D, Lachey, Jennifer L, Seeley, Randy J, Lowell, Bradford B, Elmquist, Joel K
Published in The Journal of clinical investigation (01.12.2005)
Published in The Journal of clinical investigation (01.12.2005)
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Journal Article
Discovery of [1,2,4]Triazolo[1,5‑a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists
Nakajima, Ryota, Oono, Hiroyuki, Sugiyama, Sakae, Matsueda, Yohei, Ida, Tomohide, Kakuda, Shinji, Hirata, Jun, Baba, Atsushi, Makino, Akito, Matsuyama, Ryo, White, Ryan D, Wurz, Ryan Ρ, Shin, Youngsook, Min, Xiaoshan, Guzman-Perez, Angel, Wang, Zhulun, Symons, Antony, Singh, Sanjay K, Mothe, Srinivasa Reddy, Belyakov, Sergei, Chakrabarti, Anjan, Shuto, Satoshi
Published in ACS medicinal chemistry letters (09.04.2020)
Published in ACS medicinal chemistry letters (09.04.2020)
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Journal Article
Lead Optimization and Modulation of hERG Activity in a Series of Aminooxazoline Xanthene β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors
Epstein, Oleg, Bryan, Marian C, Cheng, Alan C, Derakhchan, Katayoun, Dineen, Thomas A, Hickman, Dean, Hua, Zihao, Human, Jason B, Kreiman, Charles, Marx, Isaac E, Weiss, Matthew M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Zheng, Xiao Mei, Fremeau, Robert T, White, Ryan D, Patel, Vinod F
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
Correction to Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase
Jordan, John B, Whittington, Douglas A, Bartberger, Michael D, Sickmier, E Allen, Chen, Kui, White, Ryan D, Cheng, Yuan, Judd, Ted
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Journal Article
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease
Chen, Jian Jeffrey, Liu, Qingyian, Yuan, Chester, Gore, Vijay, Lopez, Patricia, Ma, Vu, Amegadzie, Albert, Qian, Wenyuan, Judd, Ted C., Minatti, Ana E., Brown, James, Cheng, Yuan, Xue, May, Zhong, Wenge, Dineen, Thomas A., Epstein, Oleg, Human, Jason, Kreiman, Charles, Marx, Isaac, Weiss, Matthew M., Hitchcock, Stephen A., Powers, Timothy S., Chen, Kui, Wen, Paul H., Whittington, Douglas A., Cheng, Alan C., Bartberger, Michael D., Hickman, Dean, Werner, Jonathan A., Vargas, Hugo M., Everds, Nancy E., Vonderfecht, Steven L., Dunn, Robert T., Wood, Stephen, Fremeau, Robert T., White, Ryan D., Patel, Vinod F.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Development of 2-aminooxazoline 3-azaxanthene beta-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D
Low, Jonathan D., Bartberger, Michael D., Chen, Kui, Cheng, Yuan, Fielden, Mark R., Gore, Vijay, Hickman, Dean, Liu, Qingyian, Sickmier, E. Allen, Vargas, Hugo M., Werner, Jonathan, White, Ryan D., Whittington, Douglas A., Wood, Stephen, Minatti, Ana E.
Published in MedChemComm (01.06.2017)
Published in MedChemComm (01.06.2017)
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Journal Article
The effect of the amiodarone-warfarin interaction on anticoagulation quality in a single, high-quality anticoagulation center
White, Ryan D, Riggs, Kyle W, Ege, Ed J, Petroski, Gregory F, Koerber, Scott M, Flaker, Greg
Published in Blood coagulation & fibrinolysis (01.03.2016)
Published in Blood coagulation & fibrinolysis (01.03.2016)
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Journal Article
An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities
Cheng, Yuan, Brown, James, Judd, Ted C, Lopez, Patricia, Qian, Wenyuan, Powers, Timothy S, Chen, Jian Jeffrey, Bartberger, Michael D, Chen, Kui, Dunn, Robert T, Epstein, Oleg, Fremeau, Robert T, Harried, Scott, Hickman, Dean, Hitchcock, Stephen A, Luo, Yi, Minatti, Ana Elena, Patel, Vinod F, Vargas, Hugo M, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, White, Ryan D, Whittington, Douglas A, Zheng, Xiao Mei, Wood, Stephen
Published in ACS medicinal chemistry letters (12.02.2015)
Published in ACS medicinal chemistry letters (12.02.2015)
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Journal Article
Naphthamides as Novel and Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Design, Synthesis, and Evaluation
Harmange, Jean-Christophe, Weiss, Matthew M, Germain, Julie, Polverino, Anthony J, Borg, George, Bready, James, Chen, Danlin, Choquette, Deborah, Coxon, Angela, DeMelfi, Tom, DiPietro, Lucian, Doerr, Nicholas, Estrada, Juan, Flynn, Julie, Graceffa, Russell F, Harriman, Shawn P, Kaufman, Stephen, La, Daniel S, Long, Alexander, Martin, Matthew W, Neervannan, Sesha, Patel, Vinod F, Potashman, Michele, Regal, Kelly, Roveto, Phillip M, Schrag, Michael L, Starnes, Charlie, Tasker, Andrew, Teffera, Yohannes, Wang, Ling, White, Ryan D, Whittington, Douglas A, Zanon, Roger
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Journal Article
Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Buchanan, John L, Buckner, William H, Cee, Victor J, Chai, Lilly, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Geuns-Meyer, Stephanie D, Gore, Anu, Gu, Yan, Henkle, Brad, Hodous, Brian L, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, Masse, Craig E, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian
Published in Journal of medicinal chemistry (21.09.2006)
Published in Journal of medicinal chemistry (21.09.2006)
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Journal Article
Total Synthesis of (±)-Kalihinol C
White, Ryan D, Keaney, Gregg F, Slown, Corin D, Wood, John L
Published in Organic letters (01.04.2004)
Published in Organic letters (01.04.2004)
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