Activity of Selumetinib in Neurofibromatosis Type 1–Related Plexiform Neurofibromas
Dombi, Eva, Baldwin, Andrea, Marcus, Leigh J, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Whitcomb, Patricia, Martin, Staci, Aschbacher-Smith, Lindsey E, Rizvi, Tilat A, Wu, Jianqiang, Ershler, Rachel, Wolters, Pamela, Therrien, Janet, Glod, John, Belasco, Jean B, Schorry, Elizabeth, Brofferio, Alessandra, Starosta, Amy J, Gillespie, Andrea, Doyle, Austin L, Ratner, Nancy, Widemann, Brigitte C
Published in The New England journal of medicine (29.12.2016)
Published in The New England journal of medicine (29.12.2016)
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Safe marginal resection of atypical neurofibromas in neurofibromatosis type 1
Nelson, Charlie N, Dombi, Eva, Rosenblum, Jared S, Miettinen, Markku M, Lehky, Tanya J, Whitcomb, Patricia O, Hayes, Christina, Scott, Gretchen, Benzo, Sarah, Widemann, Brigitte C, Chittiboina, Prashant
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Vandetanib in Children and Adolescents with Multiple Endocrine Neoplasia Type 2B Associated Medullary Thyroid Carcinoma
FOX, Elizabeth, WIDEMANN, Brigitte C, WELLS, Samuel A, BALIS, Frank M, CHUK, Meredith K, MARCUS, Leigh, AIKIN, Alberta, WHITCOMB, Patricia O, MERINO, Maria J, LODISH, Maya, DOMBI, Eva, STEINBERG, Seth M
Published in Clinical cancer research (01.08.2013)
Published in Clinical cancer research (01.08.2013)
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Long-term safety and efficacy of selumetinib in children with neurofibromatosis type 1 on a phase 1/2 trial for inoperable plexiform neurofibromas
Gross, Andrea M, Dombi, Eva, Wolters, Pamela L, Baldwin, Andrea, Dufek, Anne, Herrera, Kailey, Martin, Staci, Derdak, Joanne, Heisey, Kara S, Whitcomb, Patricia M, Steinberg, Seth M, Venzon, David J, Fisher, Michael J, Kim, AeRang, Bornhorst, Miriam, Weiss, Brian D, Blakeley, Jaishri O, Smith, Malcolm A, Widemann, Brigitte C
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Published in Neuro-oncology (Charlottesville, Va.) (03.10.2023)
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Phase I Trial and Pharmacokinetic Study of the Farnesyltransferase Inhibitor Tipifarnib in Children With Refractory Solid Tumors or Neurofibromatosis Type I and Plexiform Neurofibromas
WIDEMANN, Brigitte C, SALZER, Wanda L, JAYAPRAKASH, Nalini, ZANNIKOS, Peter, BALIS, Frank M, ARCECI, Robert J, BLANEY, Susan M, FOX, Elizabeth, END, David, GILLESPIE, Andrea, WHITCOMB, Patricia, PALUMBO, Joseph S, PITNEY, Aaron
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Published in Journal of clinical oncology (20.01.2006)
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Safety, Tolerance, and Pharmacokinetics of a Small Unilamellar Liposomal Formulation of Amphotericin B (AmBisome) in Neutropenic Patients
WALSH, T. J, YELDANDI, V, BEKERSKY, I, ALAK, A, BUELL, D, BARRET, J, WILSON, W, MCEVOY, M, GONZALEZ, C, CHANOCK, S, FREIFELD, A, SEIBEL, N. I, WHITCOMB, P. O, JAROSINSKI, P, BOSWELL, G
Published in Antimicrobial Agents and Chemotherapy (01.09.1998)
Published in Antimicrobial Agents and Chemotherapy (01.09.1998)
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Selumetinib in Children with Inoperable Plexiform Neurofibromas
Gross, Andrea M, Wolters, Pamela L, Dombi, Eva, Baldwin, Andrea, Whitcomb, Patricia, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Bornhorst, Miriam, Shah, Amish C, Martin, Staci, Roderick, Marie C, Pichard, Dominique C, Carbonell, Amanda, Paul, Scott M, Therrien, Janet, Kapustina, Oxana, Heisey, Kara, Clapp, D. Wade, Zhang, Chi, Peer, Cody J, Figg, William D, Smith, Malcolm, Glod, John, Blakeley, Jaishri O, Steinberg, Seth M, Venzon, David J, Doyle, L. Austin, Widemann, Brigitte C
Published in The New England journal of medicine (09.04.2020)
Published in The New England journal of medicine (09.04.2020)
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A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS–FLI1 fusion transcript
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Published in Cancer chemotherapy and pharmacology (01.09.2017)
Published in Cancer chemotherapy and pharmacology (01.09.2017)
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Audiometric and Otologic Findings in Children and Young Adults with Neurofibromatosis Type 1 and Plexiform Neurofibromas
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Selumetinib in children with neurofibromatosis type 1 and asymptomatic inoperable plexiform neurofibroma at risk for developing tumor-related morbidity
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Published in Neuro-oncology (Charlottesville, Va.) (02.11.2022)
Published in Neuro-oncology (Charlottesville, Va.) (02.11.2022)
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Selumetinib in Children with Inoperable Plexiform Neurofibromas
Published in The New England journal of medicine
(24.09.2020)
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Development and pilot validation of a novel disfigurement severity scale for plexiform neurofibromas in children with neurofibromatosis type 1
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Published in Clinical trials (London, England) (01.04.2024)
Published in Clinical trials (London, England) (01.04.2024)
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Phase II trial of the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886 Hydrogen Sulfate) in adults with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PN)
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Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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SPRINT: Phase II study of the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886) in children with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PN)
Gross, Andrea M., Wolters, Pamela, Baldwin, Andrea, Dombi, Eva, Fisher, Michael J., Weiss, Brian D., Kim, AeRang, Blakeley, Jaishri O'Neill, Whitcomb, Patricia, Holmblad, Marielle, Martin, Staci, Roderick, Marie Claire, Paul, Scott M., Therrien, Janet, Heisey, Kara, Doyle, Austin, Smith, Malcolm A., Glod, John, Steinberg, Seth M., Widemann, Brigitte C.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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The MEK inhibitor selumetinib reduces spinal neurofibroma burden in patients with NF1 and plexiform neurofibromas
Jackson, Sadhana, Baker, Eva H, Gross, Andrea M, Whitcomb, Patricia, Baldwin, Andrea, Derdak, Joanne, Tibery, Cecilia, Desanto, Jennifer, Carbonell, Amanda, Yohay, Kaleb, O’Sullivan, Geraldine, Chen, Alice P, Widemann, Brigitte C, Dombi, Eva
Published in Neuro-oncology advances (01.01.2020)
Published in Neuro-oncology advances (01.01.2020)
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NFM-07. SPRINT: PHASE II STUDY OF THE MEK 1/2 INHIBITOR SELUMETINIB (AZD6244, ARRY-142886) IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1 (NF1) AND INOPERABLE PLEXIFORM NEUROFIBROMAS (PN)
Gross, Andrea, Wolters, Pamela, Baldwin, Andrea, Dombi, Eva, Fisher, Michael J, Weiss, Brian, Kim, AeRang, Blakeley, Jaishri, Whitcomb, Patricia, Holmblad, Marielle, Maritin, Staci, Roderick, Marie Claire, Paul, Scott M, Therrien, Janet, Heisey, Kara, Doyle, Austin, Smith, Malcolm, Glod, John, Steinberg, Seth, Widemann, Brigitte C
Published in Neuro-oncology (Charlottesville, Va.) (22.06.2018)
Published in Neuro-oncology (Charlottesville, Va.) (22.06.2018)
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Phase I study of the MEK1/2 inhibitor selumetinib (AZD6244) hydrogen sulfate in children and young adults with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PNs)
Widemann, Brigitte C., Marcus, Leigh Jessica, Fisher, Michael J., Weiss, Brian D., Kim, AeRang, Dombi, Eva, Baldwin, Andrea, Whitcomb, Patricia, Martin, Staci, Gillespie, Andrea, Doyle, Austin
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Phase II trial of the MEK1/2 inhibitor selumetinib (AZD6244) in adults with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PNs)
Bradford, Diana, Whitcomb, Patricia, Dombi, Eva, Chen, Alice P., Baldwin, Andrea, Wolters, Pamela, Martin, Staci, Glod, John, Derdak, Joanne, O'Sullivan Coyne, Geraldine Helen, Cowen, Edward W., Holmblad, Marielle, Trepel, Jane, Wood, Bradford J., Paul, Scott M., Clapp, Wade, Johnson, Gary L., Rubinstein, Larry, Doyle, L. Austin, Widemann, Brigitte C.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Phase II Study of the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886) in children with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PN)
Gross, Andrea M, Baldwin, Andrea, Dombi, Eva, Wolters, Pamela, Whitcomb, Patricia, Holmblad, Marielle, Martin, Staci, Fisher, Michael J., Kim, AeRang, Weiss, Brian D., Paul, Scott M., Clapp, Wade, Farrell, Kathleen, Smith, Michaele, Fontana, Joseph, Brofferio, Alessandra, Steinberg, Seth M., Doyle, Laurence A, Widemann, Brigitte C.
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Abstract A2: Using plexiform neurofibroma preclinical therapeutics to help guide clinical trials
Wu, Jianqiang, Jousma, Edwin, Rizvi, Tilat, Dunn, Richard Scott, Jones, David R., Cripe, Timothy P., Kim, Mi-Ok, Marcus, Leigh, Dombi, Eva, Baldwin, Andrea, Long, Lauren Meyerson, Andrea, Gillespie, Whitcomb, Patricia, Peron, Staci Martin, Widemann, Brigitte, Janhofer, David, Ratner, Nancy
Published in Cancer research (Chicago, Ill.) (15.10.2014)
Published in Cancer research (Chicago, Ill.) (15.10.2014)
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