Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors
Whalen, Kerry A., Rakhra, Kavya, Mehta, Naveen K., Steinle, Alexander, Michaelson, Jennifer S., Baeuerle, Patrick A.
Published in mAbs (31.12.2023)
Published in mAbs (31.12.2023)
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Journal Article
Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Journal Article
Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
Perino, Samantha, Moreau, Benoit, Freda, Jessica, Cirello, Amanda, White, Brian H., Quinn, James M., Kriksciukaite, Kristina, Someshwar, Ashwajith, Romagnoli, Janel, Robinson, Megan, Movassaghian, Sara, Cipriani, Tyler, Wooster, Richard, Bilodeau, Mark T., Whalen, Kerry A.
Published in Molecular cancer therapeutics (01.08.2020)
Published in Molecular cancer therapeutics (01.08.2020)
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Journal Article
194 Characterization of the pharmacodynamic activity of CLN-619, an anti-MICA/B monoclonal antibody, in patients from an ongoing Phase 1 trial
Shapiro, Irina M, Whalen, Kerry A, Liu, Laura, Liu, Tracy, Michaelson, Jennifer S, Spira, Alexander I, Wang, Judy S, Hamilton, Erika, Millward, Michael, Arance, Ana Maria, Moreno, Victor, Melero, Ignacio, Stec, Rafal, Jones, Jeffrey A
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Genetic Analysis of the Polyomavirus DnaJ Domain
WHALEN, Kerry A, DE JESUS, Rowena, KEAN, Jennifer A, SCHAFFHAUSEN, Brian S
Published in Journal of Virology (01.08.2005)
Published in Journal of Virology (01.08.2005)
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Journal Article
Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo
White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Abstract 5297: CLN-619, a clinical stage MICA/B-specific hIgG1 monoclonal antibody, engages multiple immune effector cells to promote anti-tumor activity
Whalen, Kerry A., Henry, Catherine C., Rakhra, Kavya, Meetze, Kristan, Michaelson, Jennifer S., Baeuerle, Patrick A.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract CT156: Characterization of PEN-866, a Heat Shock Protein 90 (HSP90) binding conjugate of SN-38, in patient plasma and tumors from the first in human study
Thomas, Anish, Kriksciukaite, Kristina, Falchook, Gerald, Bendel, Johanna, Ulahannan, Susanna, Redon, Christophe, Mei, Laura, Whalen, Kerry, Bloss, Jeffrey, Bilodeau, Mark T.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
A phase 1 dose-escalation study to investigate the safety, efficacy, pharmacokinetics, and pharmacodynamic activity of cln-619 (Anti-MICA/B antibody) alone and in combination with pembrolizumab in patients with advanced solid tumors
Wang, Judy S., Gutierrez, Martin, Rasco, Drew W., Melero Bermejo, Ignacio, Powderly, John D., Hamilton, Erika P., Millward, Michael, Arance, Ana Maria, Stec, Rafal, Moreno, Victor, Sharma, Manish, Lugowska, Iwona A., Shackleton, Mark J., Frentzas, Sophia, Janik, John Edward, Liu, Tracy, Shapiro, Irina, Whalen, Kerry, Jones, Jeffrey Alan, Spira, Alexander I.
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Abstract 5806: Combination of the miniature drug conjugate PEN-866 with PARP inhibitors as a rational approach to overcoming limitations of PARP inhibitor monotherapy
Perino, Samantha, Quinn, James M., Callahan, Marrissa, Sharma, Gitanjali, White, Brian, Bilodeau, Mark, Alland, Leila, Whalen, Kerry, Wooster, Richard
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 2943: The structural basis for inhibition of MICA shedding and anti-tumor activity of the monoclonal anti-MICA|B antibody, CLN-619
Whalen, Kerry A., Mehta, Naveen K., Meetze, Kristan, Michaelson, Jennifer S., Baeuerle, Patrick S.
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
A phase 1 dose-escalation study to investigate the safety, efficacy, pharmacokinetics, and pharmacodynamic activity of CLN-619 (anti-MICA/MICB antibody) alone and in combination with pembrolizumab in patients with advanced solid tumors
Powderly, John D., Gutierrez, Martin, Wang, Judy S., Hamilton, Erika P., Sharma, Manish, Spira, Alexander I., Millward, Michael, Shackleton, Mark J., Frentzas, Sophia, Koczywas, Marianna, Mehta, Naveen, Christensen, Ann Marie, Shapiro, Irina, Whalen, Kerry, Michaelson, Jennifer, Baeuerle, Patrick, Janik, John Edward, Rasco, Drew W.
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Journal Article
Abstract 4328: Epigenetic modulation of SSTR2 expression provides the potential to broaden PEN-221 treatment population
Perino, Samantha, Quinn, James, Freda, Jessica, White, Brian, Bailey, Scott, Bhatia, Viren, Sweryda-Krawiec, Beata, Bilodeau, Mark, Bloss, Jeffrey D., Whalen, Kerry, Wooster, Richard
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 3506: CLN-619, a clinical-stage MICA/MICB-specific IgG1 antibody, restores the MICA/MICB-NKG2D axis to promote NK-mediated tumor cell lysis
Whalen, Kerry A., Mehta, Naveen K., Yalcin, Safak, Meetze, Kristan, Gibson, Neil W., Michaelson, Jennifer S., Baeuerle, Patrick A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo
White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
표적 치료제를 포함하는 병용 요법
BILODEAU MARK T, KADIYALA SUDHAKAR, ALLAND LEILA, PERINO SAMANTHA, WOOSTER RICHARD, SIMCOX MARY, WHALEN KERRY
Year of Publication 17.02.2020
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Year of Publication 17.02.2020
Patent
Abstract 3674: Pentarins: Improved tumor targeting through nanoparticle encapsulation of miniaturized biologic drug conjugates
Bilodeau, Mark T., Shinde, Rajesh, White, Brian, Bazinet, Patrick, Whalen, Kerry, Dupont, Michelle, Kriksciukaite, Kristina, Quinn, Jamie, Sweryda-Krawiec, Beata, Alargova, Rossitza, Brockman, Adam, Lim Soo, Patrick, Meetze, Kristan, Moreau, Benoit, Oller, Haley, Ramstack, Mike, Rockwood, Danielle, Singh, Sukhjeet, Yeung, Tsun Au, Kadiyala, Sudha, Dunbar, Craig, Wooster, Richard
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract 4484: BTP-114: An albumin binding cisplatin prodrug with improved and sustained tumor growth inhibition
Moreau, Benoit, Alargova, Rossitza, Brockman, Adam, Whalen, Kerry, Quinn, Jamie, Meetze, Kristan, Bazinet, Patrick, DuPont, Michelle, Krawiec, Beata, Kriksciukaite, Kristina, Lemelin, Charles, LimSoo, Patrick, Oller, Haley, Ramstack, Mike, Rockwood, Danielle, Shinde, Rajesh, Singh, Sukhjeet, White, Brian, AuYeung, Tsun, Dunbar, Craig, Bilodeau, Mark, Wooster, Richard
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
PLATINUM COMPOUNDS COMPOSITIONS AND USES THEREOF
BILODEAU MARK T, LEMELIN CHARLES ANDRE, SINGH SUKHJEET, WOOSTER RICHARD, MOREAU BENOIT, MEETZE KRISTAN, WHALEN KERRY
Year of Publication 28.02.2017
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Year of Publication 28.02.2017
Patent