Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2
Foster, Scott A., Whalen, Daniel M., Özen, Ayşegül, Wongchenko, Matthew J., Yin, JianPing, Yen, Ivana, Schaefer, Gabriele, Mayfield, John D., Chmielecki, Juliann, Stephens, Philip J., Albacker, Lee A., Yan, Yibing, Song, Kyung, Hatzivassiliou, Georgia, Eigenbrot, Charles, Yu, Christine, Shaw, Andrey S., Manning, Gerard, Skelton, Nicholas J., Hymowitz, Sarah G., Malek, Shiva
Published in Cancer cell (11.04.2016)
Published in Cancer cell (11.04.2016)
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Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling
Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Ingham, Philip W, Covey, Douglas F, Siebold, Christian, Rohatgi, Rajat
Published in eLife (29.10.2013)
Published in eLife (29.10.2013)
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Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
Schulze, Christopher J., Seamon, Kyle J., Zhao, Yulei, Yang, Yu C., Cregg, Jim, Kim, Dongsung, Tomlinson, Aidan, Choy, Tiffany J., Wang, Zhican, Sang, Ben, Pourfarjam, Yasin, Lucas, Jessica, Cuevas-Navarro, Antonio, Ayala-Santos, Carlos, Vides, Alberto, Li, Chuanchuan, Marquez, Abby, Zhong, Mengqi, Vemulapalli, Vidyasiri, Weller, Caroline, Gould, Andrea, Whalen, Daniel M., Salvador, Anthony, Milin, Anthony, Saldajeno-Concar, Mae, Dinglasan, Nuntana, Chen, Anqi, Evans, Jim, Knox, John E., Koltun, Elena S., Singh, Mallika, Nichols, Robert, Wildes, David, Gill, Adrian L., Smith, Jacqueline A. M., Lito, Piro
Published in Science (American Association for the Advancement of Science) (18.08.2023)
Published in Science (American Association for the Advancement of Science) (18.08.2023)
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Kinase domain dimerization drives RIPK3-dependent necroptosis
Raju, Saravanan, Whalen, Daniel M, Mengistu, Meron, Swanson, Carter, Quinn, John G, Taylor, Susan S, Webster, Joshua D, Newton, Kim, Shaw, Andrey S
Published in Science signaling (21.08.2018)
Published in Science signaling (21.08.2018)
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Journal Article
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2–Like Fold but Have Evolved to Inhibit NF-κB rather than Apoptosis
Graham, Stephen C., Bahar, Mohammad W., Cooray, Samantha, Chen, Ron A.-J., Whalen, Daniel M., Abrescia, Nicola G. A., Alderton, David, Owens, Raymond J., Stuart, David I., Smith, Geoffrey L., Grimes, Jonathan M.
Published in PLoS pathogens (01.08.2008)
Published in PLoS pathogens (01.08.2008)
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Journal Article
RAS 억제제
BUCKL ANDREAS, BURNETT G. LESLIE, WHALEN DANIEL M, KOLTUN ELENA S, GILL ADRIAN L, CREGG JAMES, AAY NAING, PITZEN JENNIFER, LIU YANG, KNOX JOHN E, AGGEN JAMES
Year of Publication 04.08.2022
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Year of Publication 04.08.2022
Patent
Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis
Graham, Stephen C, Bahar, Mohammad W, Cooray, Samantha, Chen, Ron A-J, Whalen, Daniel M, Abrescia, Nicola G A, Alderton, David, Owens, Raymond J, Stuart, David I, Smith, Geoffrey L, Grimes, Jonathan M
Published in PLoS pathogens (15.08.2008)
Published in PLoS pathogens (15.08.2008)
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Journal Article
Abstract 1261: A next generation tri-complex KRASG12C(ON) inhibitor directly targets the active, GTP-bound state of mutant RAS and may overcome resistance to KRASG12C(OFF) inhibition
Nichols, Robert J., Cregg, Jim, Schulze, Christopher J., Wang, Zhican, Yang, Kevin, Jiang, Jingjing, Whalen, Daniel M., Hansen, Rich, Garrenton, Lindsay S., Bermingham, Alun, Knox, John E., Choy, Tiffany, Reyes, Denise, Rios, Mayra, Seamon, Kyle, Longhi, Michael, Chou, Kang-Jye, Li, Shaoling, Wildes, David P., Singh, Mallika, Koltun, Elena S., Gill, Adrian L., Smith, Jacqueline A. M.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract PR10: Tri-complex inhibitors of the oncogenic, GTP-bound form of KRASG12C overcome RTK-mediated escape mechanisms and drive tumor regressions in vivo
Schulze, Christopher J, Bermingham, Alun, Choy, Tiffany J, Cregg, James J, Kiss, Gert, Marquez, Abby, Reyes, Denise, Saldajeno-Concar, Mae, Weller, Caroline E, Whalen, Daniel M, Yang, Yu C, Koltun, Elena S, Nichols, Robert J, Singh, Mallika, Wildes, David, Gill, Adrian L, Hansen, Richard L, Kelsey, Steve, Goldsmith, Mark A, Smith, Jacqueline A.M.
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Journal Article
Vaccinia Virus Proteins A52 and B14 Share a Bcl-2-Like Fold but Have Evolved to Inhibit NF-[kappa]B rather than Apoptosis: e1000128
Graham, Stephen C, Bahar, Mohammad W, Cooray, Samantha, Chen, Ron A-J, Whalen, Daniel M, Abrescia, Nicola GA, Alderton, David, Owens, Raymond J, Stuart, David I, Smith, Geoffrey L, Grimes, Jonathan M
Published in PLoS pathogens (01.08.2008)
Published in PLoS pathogens (01.08.2008)
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Journal Article
RAS INHIBITORS
AAY, Naing, PITZEN, Jennifer, BUCKL, Andreas, AGGEN, James, WHALEN, Daniel M, LIU, Yang, CREGG, James, GILL, Adrian L, KOLTUN, Elena S, BURNETT, G. Leslie, KNOX, John E
Year of Publication 23.11.2023
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Year of Publication 23.11.2023
Patent
RAS INHIBITORS
KOLTUN, Elena, S, WHALEN, Daniel, M, BURNETT, G., Leslie, KNOX, John, E, AAY, Naing, PITZEN, Jennifer, GILL, Adrian, L, BUCKL, Andreas, AGGEN, James, LIU, Yang, CREGG, James
Year of Publication 14.09.2022
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Year of Publication 14.09.2022
Patent
Ras inhibitors
AAY, Naing, PITZEN, Jennifer, BUCKL, Andreas, AGGEN, James, WHALEN, Daniel M, LIU, Yang, CREGG, James, GILL, Adrian L, KOLTUN, Elena S, BURNETT, G. Leslie, KNOX, John E
Year of Publication 05.05.2022
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Year of Publication 05.05.2022
Patent
RAS INHIBITORS
CREGG, JAMES, BUCKL, ANDREAS, PITZEN, JENNIFER, KOLTUN, ELENA S, BURNETT, G. LESLIE, LIU, YANG, AGGEN, JAMES, KNOX, JOHN E, GILL, ADRIAN L, AAY, NAING, WHALEN, DANIEL M
Year of Publication 14.05.2021
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Year of Publication 14.05.2021
Patent
RAS INHIBITORS
AAY, Naing, PITZEN, Jennifer, BUCKL, Andreas, AGGEN, James, WHALEN, Daniel M, LIU, Yang, CREGG, James, GILL, Adrian L, KOLTUN, Elena S, BURNETT, G. Leslie, KNOX, John E
Year of Publication 06.05.2021
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Year of Publication 06.05.2021
Patent