Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties
Pinto, Donald J.P., Galemmo, Robert A., Quan, Mimi L., Orwat, Michael J., Clark, Charles, Li, Renhua, Wells, Brian, Woerner, Francis, Alexander, Richard S., Rossi, Karen A., Smallwood, Angela, Wong, Pancras C., Luettgen, Joseph M., Rendina, Alan R., Knabb, Robert M., He, Kan, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
Published in Bioorganic & medicinal chemistry letters (01.11.2006)
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Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues
Qiao, Jennifer X., Cheng, Xuhong, Smallheer, Joanne M., Galemmo, Robert A., Drummond, Spencer, Pinto, Donald J.P., Cheney, Daniel L., He, Kan, Wong, Pancras C., Luettgen, Joseph M., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
Published in Bioorganic & medicinal chemistry letters (01.03.2007)
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XIa P2' MACROCYCLES WITH HETROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS
SMITH LEON M. II, WEXLER RUTH R, ZHU YEHENG, ORWAT MICHAEL J, PINTO DONALD J. P, DE LUCCA INDAWATI, PABBISETTY KUMAR BALASHANMUGA, FANG TIANAN, WANG YUFENG, DILGER ANDREW K, EWING WILLIAM R, CORTE JAMES R, YANG WU
Year of Publication 06.02.2024
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Year of Publication 06.02.2024
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SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
SMALLHEER, Joanne M, ALEXANDER, Richard S, KNABB, Robert M, WEXLER, Ruth R, JADHAV, Prabhakar K, JIANMIN WANG, SHUAIGE WANG, NAKAJIMA, Suanne, ROSSI, Karen A, SMALLWOOD, Angela, BARBERA, Frank, BURDICK, Debra, LUETTGEN, Joseph M
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors
Yang, Michael G., Shi, Jian-Liang, Modi, Dilip P., Wells, Jennifer, Cochran, Brian M., Wolf, Mark A., Thompson, Lorin A., Ramanjulu, Mercy M., Roach, Arthur H., Zaczek, Robert, Robertson, David W., Wexler, Ruth R., Olson, Richard E.
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
Published in Bioorganic & medicinal chemistry letters (15.07.2007)
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Sulfonamidolactam inhibitors of coagulation factor Xa
Smallheer, Joanne M., Wang, Shuaige, Laws, Mia L., Nakajima, Suanne, Hu, Zilun, Han, Wei, Jacobson, Irina, Luettgen, Joseph M., Rossi, Karen A., Rendina, Alan R., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa
BATT, Douglas G, QIAO, Jennifer X, MODI, Dilip P, HOUGHTON, Gregory C, PIERSON, Deborah A, ROSSI, Karen A, LUETTGEN, Joseph M, KNABB, Robert M, JADHAV, P. K, WEXLER, Ruth R
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Synthesis and pharmacology of modified amidine isoxazoline glycoprotein IIb/IIIa receptor antagonists
Sielecki, Thais M, Liu, Jie, Mousa, Shaker A, Racanelli, Adrienne L, Hausner, Elizabeth A, Wexler, Ruth R, Olson, Richard E
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
Published in Bioorganic & medicinal chemistry letters (20.08.2001)
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Synthesis and biological evaluation of nonpeptide integrin antagonists containing spirocyclic scaffolds
Smallheer, Joanne M., Weigelt, Carolyn A., Woerner, Francis J., Wells, Jennifer S., Daneker, Wayne F., Mousa, Shaker A., Wexler, Ruth R., Jadhav, Prabhakar K.
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
Published in Bioorganic & medicinal chemistry letters (19.01.2004)
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Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors
Quan, Mimi L., Han, Qi, Fevig, John M., Lam, Patrick Y.S., Bai, Steve, Knabb, Robert M., Luettgen, Joseph M., Wong, Pancras C., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
Published in Bioorganic & medicinal chemistry letters (01.04.2006)
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Journal Article
XIa P2' MACROCYCLES WITH HETROCYCLIC P2' GROUPS AS FACTOR XIA INHIBITORS
SMITH LEON M. II, WEXLER RUTH R, ZHU YEHENG, ORWAT MICHAEL J, PINTO DONALD J. P, DE LUCCA INDAWATI, PABBISETTY KUMAR BALASHANMUGA, FANG TIANAN, WANG YUFENG, DILGER ANDREW K, EWING WILLIAM R, CORTE JAMES R, YANG WU
Year of Publication 05.07.2022
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Year of Publication 05.07.2022
Patent
5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa
Batt, Douglas G, Qiao, Jennifer X, Modi, Dilip P, Houghton, Gregory C, Pierson, Deborah A, Rossi, Karen A, Luettgen, Joseph M, Knabb, Robert M, Jadhav, P K, Wexler, Ruth R
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Identification of angiotensin II receptor subtypes
Chiu, Andrew T., Herblin, William F., McCall, Dale E., Ardecky, Robert J., Carini, David J., Duncia, John V., Pease, Lori J., Wong, Pancras C., Wexler, Ruth R., Johnson, Alexander L., Timmermans, Pieter B.M.W.M.
Published in Biochemical and biophysical research communications (30.11.1989)
Published in Biochemical and biophysical research communications (30.11.1989)
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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release
Xue, Chu-Biao, He, Xiaohua, Corbett, Ronald L, Roderick, John, Wasserman, Zelda R, Liu, Rui-Qin, Jaffee, Bruce D, Covington, Maryanne B, Qian, Mingxin, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-α converting enzyme inhibitors. Part 2: Lead optimization
XUE, Chu-Biao, XIAOHUA HE, CHRIST, David D, NEWTON, Robert C, TRZASKOS, James M, MAGOLDA, Ronald L, WEXLER, Ruth R, DECICCO, Carl P, RODERICK, John, CORBETT, Ronald L, DUAN, James J.-W, LIU, Rui-Qin, COVINGTON, Maryanne B, MINGXIN QIAN, RIBADENEIRA, Maria D, VADDI, Krishna
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Isoxazolines and isoxazoles as Factor Xa inhibitors
PRUITT, J. R, PINTO, D. J, ESTRELLA, M. J, BOSTROM, L. L, KNABB, R. M, WONG, P. C, WRIGHT, M. R, WEXLER, R. R
Published in Bioorganic & medicinal chemistry letters (17.04.2000)
Published in Bioorganic & medicinal chemistry letters (17.04.2000)
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Journal Article
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-α converting enzyme inhibitors. Part 1: Lead identification
XUE, Chu-Biao, XIAOHUA HE, WEXLER, Ruth R, DECICCO, Carl P, RODERICK, John, CORBETT, Ronald L, DUAN, James J.-W, LIU, Rui-Qin, COVINGTON, Maryanne B, NEWTON, Robert C, TRZASKOS, James M, MAGOLDA, Ronald L
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Preclinical Pharmacokinetic and Metabolism of Apixaban, a Potent and Selective Factor Xa Inhibitor
He, Kan, He, Bing, Grace, James E., Xin, Baomin, Zhang, Donglu, Pinto, Donald J., Luettgen, Joseph M., Knabb, Robert M., Lam, Patrick Y.S., Wexler, Ruth R., Humphreys, William G., Shyu, Wen-Chyi, Grossman, Scott J.
Published in Blood (16.11.2006)
Published in Blood (16.11.2006)
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Nonbenzamidine tetrazole derivatives as factor Xa inhibitors
Quan, Mimi L, Ellis, Christopher D, He, Ming Y, Liauw, Ann Y, Woerner, Francis J, Alexander, Richard S, Knabb, Robert M, Lam, Patrick Y.S, Luettgen, Joseph M, Wong, Pancras C, Wright, Matthew R, Wexler, Ruth R
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
Published in Bioorganic & medicinal chemistry letters (10.02.2003)
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