New azole antagonists with high affinity for the P2Y1 receptor
Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Daris, Jean-Paul, Martel, Alain, Price, Laura A., Wu, Qimin, Hua, Ji, Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Published in Bioorganic & medicinal chemistry letters (15.06.2013)
Get full text
Journal Article
Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors
Wurtz, Nicholas R, Parkhurst, Brandon L, Jiang, Wen, DeLucca, Indawati, Zhang, Xiaojun, Ladziata, Vladimir, Cheney, Daniel L, Bozarth, Jeffrey R, Rendina, Alan R, Wei, Anzhi, Luettgen, Joseph M, Wu, Yiming, Wong, Pancras C, Seiffert, Dietmar A, Wexler, Ruth R, Priestley, E. Scott
Published in ACS medicinal chemistry letters (08.12.2016)
Published in ACS medicinal chemistry letters (08.12.2016)
Get full text
Journal Article
PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
Hangeland, Jon J., Abell, Lynn M., Adam, Leonard P., Jiang, Ji, Friends, Todd J., Haque, Lauren E., Neels, James, Onorato, Joelle M., Chen, Alice Ye A., Taylor, David S., Yin, Xiaohong, Harrity, Thomas W., Basso, Michael D., Yang, Richard, Sleph, Paul G., Gordon, David A., Huang, Christine S., Wexler, Ruth R., Finlay, Heather J., Lawrence, R. Michael
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
Get full text
Journal Article
Discovery of 5‑Phenyl‑N‑(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine as a Potent I Kur Inhibitor
Finlay, Heather J, Johnson, James A, Lloyd, John L, Jiang, Ji, Neels, James, Gunaga, Prashantha, Banerjee, Abhisek, Dhondi, Naveen, Chimalakonda, Anjaneya, Mandlekar, Sandhya, Conder, Mary Lee, Sale, Harinath, Xing, Dezhi, Levesque, Paul, Wexler, Ruth R
Published in ACS medicinal chemistry letters (08.09.2016)
Published in ACS medicinal chemistry letters (08.09.2016)
Get full text
Journal Article
2-Amino-1,3,4-thiadiazoles in the 7-hydroxy-N-neopentyl spiropiperidine indolinyl series as potent P2Y1 receptor antagonists
Hu, Carol H., Qiao, Jennifer X., Han, Ying, Wang, Tammy C., Hua, Ji, Price, Laura A., Wu, Qimin, Shen, Hong, Huang, Christine S., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.06.2014)
Published in Bioorganic & medicinal chemistry letters (01.06.2014)
Get full text
Journal Article
Design, synthesis and evaluation of phenethylaminoheterocycles as K(v)1.5 inhibitors
Johnson, James A., Xu, Ningning, Jeon, Yoon, Finlay, Heather J., Kover, Alexander, Conder, Mary L., Sun, Huabin, Li, Danshi, Levesque, Paul, Hsueh, Mei-Mann, Harper, Timothy W., Wexler, Ruth R., Lloyd, John
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Published in Bioorganic & medicinal chemistry letters (15.07.2014)
Get full text
Journal Article
2-Aminothiazole based P2Y1 antagonists as novel antiplatelet agents
Pi, Zulan, Sutton, James, Lloyd, John, Hua, Ji, Price, Laura, Wu, Qimin, Chang, Ming, Zheng, Joanna, Rehfuss, Robert, Huang, Christine S., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Published in Bioorganic & medicinal chemistry letters (15.07.2013)
Get full text
Journal Article
Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties
Orwat, Michael J., Qiao, Jennifer X., He, Kan, Rendina, Alan R., Luettgen, Joseph M., Rossi, Karen A., Xin, Baomin, Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y. S., Pinto, Donald J. P.
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Published in Bioorganic & medicinal chemistry letters (01.08.2014)
Get full text
Journal Article
Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor
Finlay, Heather J, Jiang, Ji, Rampulla, Richard, Salvati, Mark E, Qiao, Jennifer X, Wang, Tammy C, Lawrence, R. Michael, Harikrishnan, Lalgudi S, Kamau, Muthoni G, Taylor, David S, Chen, Alice Ye A, Yin, Xiaohong, Huang, Christine S, Chang, Ming, Chen, Xue-Qing, Sleph, Paul G, Xu, Carrie, Li, Julia, Levesque, Paul, Adam, Leonard P, Wexler, Ruth R
Published in ACS medicinal chemistry letters (13.06.2019)
Published in ACS medicinal chemistry letters (13.06.2019)
Get full text
Journal Article
Nonbenzamidine acylsulfonamide tissue factor–factor VIIa inhibitors
Glunz, Peter W., Zhang, Xiaojun, Zou, Yan, Delucca, Indawati, Nirschl, Alexandra H., Cheng, Xuhong, Weigelt, Carolyn A., Cheney, Daniel L., Wei, Anzhi, Anumula, Rushith, Luettgen, Joseph M., Rendina, Alan R., Harpel, Mark, Luo, Gang, Knabb, Robert, Wong, Pancras C., Wexler, Ruth R., Priestley, E. Scott
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Published in Bioorganic & medicinal chemistry letters (15.09.2013)
Get full text
Journal Article
Synthesis of tertiary carbinamines
Kamau, Muthoni G., Harikrishnan, Lalgudi S., Finlay, Heather J., Qiao, Jennifer X., Jiang, Ji, Poss, Michael A., Salvati, Mark E., Wexler, Ruth R., Lawrence, R. Michael
Published in Tetrahedron (25.03.2012)
Published in Tetrahedron (25.03.2012)
Get full text
Journal Article
Identification of 1-{2-[4-chloro-1 '-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4 '-piperidine]-1-yl] phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent
Jeon, Yoon T., Yang, Wu, Qiao, Jennifer X., Li, Ling, Ruel, Rejean, Thibeault, Carl, Hiebert, Sheldon, Wang, Tammy C., Wang, Yufeng, Liu, Yajun, Clark, Charles G., Wong, Henry S., Zhu, Juliang, Wu, Dauh-Rurng, Sun, Dawn, Chen, Bang-Chi, Mathur, Arvind, Chacko, Silvi A., Malley, Mary, Chen, Xue-Qing, Shen, Hong, Huang, Christine S., Schumacher, William A., Bostwick, Jeffrey S., Stewart, Anne B., Price, Laura A., Hua, Ji, Li, Danshi, Levesque, Paul C., Seiffert, Dietmar A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Get full text
Journal Article
Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility
Wang, Tammy C., Qia, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y. S.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Get full text
Journal Article
Diphenylpyridylethanamine (DPPE) Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors
Harikrishnan, Lalgudi S, Finlay, Heather J, Qiao, Jennifer X, Kamau, Muthoni G, Jiang, Ji, Wang, Tammy C, Li, James, Cooper, Christopher B, Poss, Michael A, Adam, Leonard P, Taylor, David S, Chen, Alice Ye A, Yin, Xiaohong, Sleph, Paul G, Yang, Richard Z, Sitkoff, Doree F, Galella, Michael A, Nirschl, David S, Van Kirk, Katy, Miller, Arthur V, Huang, Christine S, Chang, Ming, Chen, Xue-Qing, Salvati, Mark E, Wexler, Ruth R, Lawrence, R. Michael
Published in Journal of medicinal chemistry (12.07.2012)
Published in Journal of medicinal chemistry (12.07.2012)
Get full text
Journal Article
Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors
Richter, Jeremy M, Cheney, Daniel L, Bates, J. Alex, Wei, Anzhi, Luettgen, Joseph M, Rendina, Alan R, Harper, Timothy M, Narayanan, Rangaraj, Wong, Pancras C, Seiffert, Dietmar, Wexler, Ruth R, Priestley, E. Scott
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
Get full text
Journal Article
Discovery of diarylurea P2Y1 antagonists with improved aqueous solubility
Wang, Tammy C., Qiao, Jennifer X., Clark, Charles G., Jua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Everlof, Gerry, Schumacher, William A., Wong, Pancras C., Seiffert, Dietmar A., Stewart, Anne B., Bostwick, Jeffrey S., Crain, Earl J., Watson, Carol A., Rehfuss, Robert, Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Published in Bioorganic & medicinal chemistry letters (01.06.2013)
Get full text
Journal Article
Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)‑one as the P2′ Moiety
Hu, Zilun, Wong, Pancras C, Gilligan, Paul J, Han, Wei, Pabbisetty, Kumar B, Bozarth, Jeffrey M, Crain, Earl J, Harper, Timothy, Luettgen, Joseph M, Myers, Joseph E, Ramamurthy, Vidhyashankar, Rossi, Karen A, Sheriff, Steven, Watson, Carol A, Wei, Anzi, Zheng, Joanna J, Seiffert, Dietmar A, Wexler, Ruth R, Quan, Mimi L
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
Get full text
Journal Article
Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds
Ruel, Réjean, L’Heureux, Alexandre, Thibeault, Carl, Lapointe, Philippe, Martel, Alain, Qiao, Jennifer X., Hua, Ji, Price, Laura A., Wu, Qimin, Chang, Ming, Zheng, Joanna, Huang, Christine S., Wexler, Ruth R., Rehfuss, Robert, Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Published in Bioorganic & medicinal chemistry letters (15.12.2013)
Get full text
Journal Article
Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors
Miller, Michael M., Liu, Yalei, Jiang, Ji, Johnson, James A., Kamau, Muthoni, Nirschl, David S., Wang, Yufeng, Harikrishnan, Lalgudi, Taylor, David S., Chen, Alice Ye A., Yin, Xiaohong, Seethala, Ramakrishna, Peterson, Tara L., Zvyaga, Tatyana, Zhang, Jun, Huang, Christine S., Wexler, Ruth R., Poss, Michael A., Michael Lawrence, R., Adam, Leonard P., Salvati, Mark E.
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
Published in Bioorganic & medicinal chemistry letters (15.10.2012)
Get full text
Journal Article
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors
Zhang, Xiaojun, Glunz, Peter W., Jiang, Wen, Schmitt, Aaron, Newman, Makenzie, Barbera, Frank A., Bozarth, Jeffery M., Rendina, Alan R., Wei, Anzhi, Wen, Xiao, Rossi, Karen A., Luettgen, Joseph M., Wong, Pancras C., Knabb, Robert M., Wexler, Ruth R., Scott Priestley, E.
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Get full text
Journal Article