Identification of 5H-chromeno[3,4-c]pyridine and 6H-isochromeno[3,4-c]pyridine derivatives as potent and selective dual ROCK inhibitors
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Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure
Richter, Jeremy M., Gunaga, Prashantha, Yadav, Navnath, Bora, Rajesh Onkardas, Bhide, Rajeev, Rajugowda, Nagendra, Govindrajulu, Kavitha, Godesi, Sreenivasulu, Akuthota, Nagarjuna, Rao, Prasanna, Sivaraman, Aneesh, Panda, Manoranjan, Kaspady, Mahammed, Gupta, Anuradha, Mathur, Arvind, Levesque, Paul C., Gulia, Jyoti, Dokania, Manoj, Ramarao, Manjunath, Kole, Prashant, Chacko, Silvi, Lentz, Kimberley A., Sivaprasad LVJ, Sankara, Thatipamula, Rajendra Prasad, Sridhar, Srikanth, Kamble, Shyam, Govindrajan, Arun, Soleman, Sharif I., Gordon, David A., Wexler, Ruth R., Priestley, E. Scott
Published in Journal of medicinal chemistry (13.06.2024)
Published in Journal of medicinal chemistry (13.06.2024)
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Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis
Zhang, Xiaojun, Jiang, Wen, Richter, Jeremy M., Bates, J. Alex, Reznik, Samuel K., Stachura, Sylwia, Rampulla, Richard, Doddalingappa, Dyamanna, Ulaganathan, Sankar, Hua, Ji, Bostwick, Jeffrey S., Sum, Chi, Posy, Shana, Malmstrom, Sarah, Dickey, Joyce, Harden, David, Lawrence, R. Michael, Guarino, Victor R., Schumacher, William A., Wong, Pancras, Yang, Jing, Gordon, David A., Wexler, Ruth R., Priestley, E. Scott
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists
Tora, George, Jiang, Ji, Bostwick, Jeffrey S., Gargalovic, Peter S., Onorato, Joelle M., Luk, Chiuwa E., Generaux, Claudia, Xu, Carrie, Galella, Michael A., Wang, Tao, He, Yan, Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
Published in Bioorganic & medicinal chemistry letters (15.10.2021)
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Design and preparation of N-linked hydroxypyridine-based APJ agonists
Richter, Jeremy M., Alex Bates, J., Gargalovic, Peter, Onorato, Joelle M., Generaux, Claudia, Wang, Tao, Gordon, David A., Wexler, Ruth R., Finlay, Heather J.
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
Published in Bioorganic & medicinal chemistry letters (01.10.2022)
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Empowering Voices: Inspiring Women in Medicinal Chemistry
Blanco, Maria-Jesus, Bronson, Joanne J., DiMauro, Erin F., Dzierba, Carolyn, Eggen, MariJean, Garner, Amanda L., Georg, Gunda, Giarolla, Jeanine, Goodwin, Nicole C., Grenier-Davies, Melissa C., Haskell-Luevano, Carrie, Holzgrabe, Ulrike, Huang, Rong, Lagiakos, H. Rachel, Leftheris, Katerina, Martin, Yvonne, Matos, Maria João, May-Dracka, Tricia L., Müller, Christa E., Newman, Amy H., Parmee, Emma, Petter, Jennifer C., Tamayo, Nuria A., Wexler, Ruth R., Bolognesi, Maria Laura, Ripka, Amy, Young, Wendy
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO)
Hu, Carol H., Neissel Valente, Meriah W., Halpern, O. Scott, Jusuf, Sutjano, Khan, Javed A., Locke, Gregory A., Duke, Gerald J., Liu, Xiaoqin, Duclos, Franck J., Wexler, Ruth R., Kick, Ellen K., Smallheer, Joanne M.
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
Published in Bioorganic & medicinal chemistry letters (15.06.2021)
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Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate
Johnson, James A, Kim, Soong-Hoon, Jiang, Ji, Phillips, Monique, Schumacher, William A, Bostwick, Jeffrey S, Gargalovic, Peter S, Onorato, Joelle M, Luk, Chiuwa E, Generaux, Claudia, He, Yan, Chen, Xue-Qing, Xu, Carrie, Galella, Michael A, Wang, Tao, Gordon, David A, Wexler, Ruth R, Finlay, Heather J
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase
Shaw, Scott A., Vokits, Benjamin P., Dilger, Andrew K., Viet, Andrew, Clark, Charles G., Abell, Lynn M., Locke, Gregory A., Duke, Gerald, Kopcho, Lisa M., Dongre, Ashok, Gao, Ji, Krishnakumar, Arathi, Jusuf, Sutjano, Khan, Javed, Spronk, Steven A., Basso, Michael D., Zhao, Lei, Cantor, Glenn H., Onorato, Joelle M., Wexler, Ruth R., Duclos, Franck, Kick, Ellen K.
Published in Bioorganic & medicinal chemistry (15.11.2020)
Published in Bioorganic & medicinal chemistry (15.11.2020)
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Design, structure–activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors
Varnes, Jeffrey G., Wacker, Dean A., Jacobson, Irina C., Quan, Mimi L., Ellis, Christopher D., Rossi, Karen A., He, Ming Y., Luettgen, Joseph M., Knabb, Robert M., Bai, Steven, He, Kan, Lam, Patrick Y.S., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry (01.12.2007)
Published in Bioorganic & medicinal chemistry (01.12.2007)
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Nonpeptide Factor Xa Inhibitors III: Effects of DPC423, an Orally-Active Pyrazole Antithrombotic Agent, on Arterial Thrombosis in Rabbits
Wong, Pancras C, Crain, Earl J, Watson, Carol A, Zaspel, Alverna M, Wright, Matthew R, Lam, Patrick Y, Pinto, Donald J P, Wexler, Ruth R, Knabb, Robert M
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2002)
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Atropisomer Control in Macrocyclic Factor VIIa Inhibitors
Glunz, Peter W, Mueller, Luciano, Cheney, Daniel L, Ladziata, Vladimir, Zou, Yan, Wurtz, Nicholas R, Wei, Anzhi, Wong, Pancras C, Wexler, Ruth R, Priestley, E. Scott
Published in Journal of medicinal chemistry (28.04.2016)
Published in Journal of medicinal chemistry (28.04.2016)
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Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker
Corte, James R, Fang, Tianan, Osuna, Honey, Pinto, Donald J. P, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Harper, Timothy W, Bozarth, Jeffrey M, Wu, Yiming, Luettgen, Joseph M, Seiffert, Dietmar A, Decicco, Carl P, Wexler, Ruth R, Quan, Mimi L
Published in Journal of medicinal chemistry (09.02.2017)
Published in Journal of medicinal chemistry (09.02.2017)
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Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species
Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Corte, James R, Fang, Tianan, Gilligan, Paul J, Jeon, Yoon, Pabbisetty, Kumar B, Rampulla, Richard A, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Arumugam, Arunachalam, Raju, Sivashankaran, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Zheng, Joanna J, Chacko, Silvi A, Bozarth, Jeffrey M, Wu, Yiming, Crain, Earl J, Wong, Pancras C, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups
Corte, James R, Pinto, Donald J. P, Fang, Tianan, Osuna, Honey, Yang, Wu, Wang, Yufeng, Lai, Amy, Clark, Charles G, Sun, Jung-Hui, Rampulla, Richard, Mathur, Arvind, Kaspady, Mahammed, Neithnadka, Premsai Rai, Li, Yi-Xin Cindy, Rossi, Karen A, Myers, Joseph E, Sheriff, Steven, Lou, Zhen, Harper, Timothy W, Huang, Christine, Zheng, Joanna J, Bozarth, Jeffrey M, Wu, Yiming, Wong, Pancras C, Crain, Earl J, Seiffert, Dietmar A, Luettgen, Joseph M, Lam, Patrick Y. S, Wexler, Ruth R, Ewing, William R
Published in Journal of medicinal chemistry (23.01.2020)
Published in Journal of medicinal chemistry (23.01.2020)
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Journal Article
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors
Hu, Zilun, Wang, Cailan, Han, Wei, Rossi, Karen A., Bozarth, Jeffrey M., Wu, Yiming, Sheriff, Steven, Myers, Joseph E., Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
Published in Bioorganic & medicinal chemistry letters (01.04.2018)
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Discovery and Optimization of Aryl Piperidinone Ureas as Selective Formyl Peptide Receptor 2 Agonists
Wurtz, Nicholas R., Shirude, Pravin S., Cheney, Daniel L., Lupisella, John A., Chattopadhyay, Amit Kumar, Baligar, Vishweshwaraiah, Seshadri, Balaji, Anjanappa, Prakash, Viet, Andrew, Valente, Meriah N., Hsu, Mei-Yin, Abousleiman, Mojgan, Sarodaya, Sanket, Tagore, Debarati M., Dudhgaonkar, Shailesh, Putlur, Sivaprasad, Dierks, Elizabeth A., Ostrowski, Jacek, Wexler, Ruth R., Garcia, Ricardo, Kick, Ellen K.
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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Journal Article
Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors
Quan, Mimi L, Wong, Pancras C, Wang, Cailan, Woerner, Francis, Smallheer, Joanne M, Barbera, Frank A, Bozarth, Jeffrey M, Brown, Randi L, Harpel, Mark R, Luettgen, Joseph M, Morin, Paul E, Peterson, Tara, Ramamurthy, Vidhyashankar, Rendina, Alan R, Rossi, Karen A, Watson, Carol A, Wei, Anzhi, Zhang, Ge, Seiffert, Dietmar, Wexler, Ruth R
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Journal Article
Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies
Hu, Zilun, Wang, Cailan, Glunz, Peter W., Li, Julia, Cheadle, Nathan L., Chen, Alice Y., Chen, Xue-Qing, Myers, Joseph E., Guarino, Victor R., Rose, Anne, Sack, John S., Sitkoff, Doree, Taylor, David S., Xu, Songmei, Yan, Chunhong, Zhang, Hongwei, Zhang, Lisa, Hennan, James, Adam, Leonard P., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
Published in Bioorganic & medicinal chemistry letters (01.11.2020)
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