Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family
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IRAK-4 inhibitors for inflammation
Wang, Zhulun, Wesche, Holger, Stevens, Tracey, Walker, Nigel, Yeh, Wen-Chen
Published in Current topics in medicinal chemistry (01.05.2009)
Published in Current topics in medicinal chemistry (01.05.2009)
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Peptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
Schwandner, R, Dziarski, R, Wesche, H, Rothe, M, Kirschning, C J
Published in The Journal of biological chemistry (18.06.1999)
Published in The Journal of biological chemistry (18.06.1999)
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Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors
Jiao, XianYun, Kopecky, David J., Liu, JinSong, Liu, JinQian, Jaen, Juan C., Cardozo, Mario G., Sharma, Rajiv, Walker, Nigel, Wesche, Holger, Li, Shyun, Farrelly, Ellyn, Xiao, Shou-Hua, Wang, Zhulun, Kayser, Frank
Published in Bioorganic & medicinal chemistry letters (01.10.2012)
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Rex, Karen, Jeffries, Shawn, Brown, Matthew L, Carlson, Timothy, Coxon, Angela, Fajardo, Flordeliza, Frank, Brendon, Gustin, Darin, Kamb, Alexander, Kassner, Paul D, Li, Shyun, Li, Yihong, Morgenstern, Kurt, Plant, Matthew, Quon, Kim, Ruefli-Brasse, Astrid, Schmidt, Joanna, Swearingen, Elissa, Walker, Nigel, Wang, Zhulun, Watson, J E Vivienne, Wickramasinghe, Dineli, Wong, Mariwil, Xu, Guifen, Wesche, Holger
Published in PloS one (05.07.2013)
Published in PloS one (05.07.2013)
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Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
Kirschning, C J, Wesche, H, Merrill Ayres, T, Rothe, M
Published in The Journal of experimental medicine (07.12.1998)
Published in The Journal of experimental medicine (07.12.1998)
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Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
Kollewe, Christian, Mackensen, Anne-Christin, Neumann, Detlef, Knop, Johannes, Cao, Ping, Li, Shyun, Wesche, Holger, Martin, Michael U.
Published in The Journal of biological chemistry (13.02.2004)
Published in The Journal of biological chemistry (13.02.2004)
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Molecular signatures of prostate stem cells reveal novel signaling pathways and provide insights into prostate cancer
Blum, Roy, Gupta, Rashmi, Burger, Patricia E, Ontiveros, Christopher S, Salm, Sarah N, Xiong, Xiaozhong, Kamb, Alexander, Wesche, Holger, Marshall, Lisa, Cutler, Gene, Wang, Xiangyun, Zavadil, Jiri, Moscatelli, David, Wilson, E Lynette
Published in PloS one (29.05.2009)
Published in PloS one (29.05.2009)
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IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family
Wesche, H, Gao, X, Li, X, Kirschning, C J, Stark, G R, Cao, Z
Published in The Journal of biological chemistry (02.07.1999)
Published in The Journal of biological chemistry (02.07.1999)
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Metastatic Properties and Genomic Amplification of the Tyrosine Kinase Gene ACK1
Edward Htun van der Horst, Yan Y. Degenhardt, Strelow, Astrid, Slavin, Anthony, Lawrence Chinn, Jessica Orf, Rong, Minqing, Li, Shyun, Lei-Hoon See, Ken Q. C. Nguyen, Hoey, Timothy, Wesche, Holger, Powers, Scott, McKnight, Steven L.
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (01.11.2005)
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867 TriTAC-XR is an extended-release T cell engager platform designed to minimize cytokine release syndrome by reducing Cmax in systemic circulation
Kwant, Kathryn, Rocha, Sony, Stephenson, Katrina, Dayao, Maria, Thothathri, Subramanian, Banzon, Rose, Aaron, Wade, Hemmati, Golzar, Callihan, Evan, Yu, Timothy, O’Rear, Jessica, Bragg, Eric, Kwong, Willis, Situ, Hubert, Hundal, Avneel, Yu, Stephen, Jackson, Taggra, Wright, Kevin, Xiao, Yinghua, To, Linh, Austin, Richard, Lemon, Bryan, Wesche, Holger, Jack Lin, S
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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632 HPN601 is a protease-activated EpCAM-targeting T cell engager with an improved safety profile for the treatment of solid tumors
Lin, Jack, Rocha, Sony, Kwant, Kathryn, Dayao, Maria, Ng, Tessie, Aaron, Wade, Callihan, Evan, Gamez-Guerrero, Maria, Hemmati, Golzar, Wright, Kevin, Barath, Manasi, Xiao, Yinghua, Degree, Master, Yu, Timothy, Chew, Patrick, Evans, Thomas, O’Rear, Jessica, Gatto, Scott, Cremin, Michael, Yu, Stephen, Patnaik, Purbasa, Hundal, Avneel, Austin, Richard, Lemon, Bryan, Wesche, Holger
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Molecular signatures of the primitive prostate stem cell niche reveal novel mesenchymal-epithelial signaling pathways
Blum, Roy, Gupta, Rashmi, Burger, Patricia E, Ontiveros, Christopher S, Salm, Sarah N, Xiong, Xiaozhong, Kamb, Alexander, Wesche, Holger, Marshall, Lisa, Cutler, Gene, Wang, Xiangyun, Zavadil, Jiri, Moscatelli, David, Wilson, E Lynette
Published in PloS one (30.09.2010)
Published in PloS one (30.09.2010)
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The Interleukin-1 Receptor Accessory Protein (IL-1RAcP) Is Essential for IL-1-induced Activation of Interleukin-1 Receptor-associated Kinase (IRAK) and Stress-activated Protein Kinases (SAP Kinases)
Wesche, Holger, Korherr, Christian, Kracht, Michael, Falk, Werner, Resch, Klaus, Martin, Michael U.
Published in The Journal of biological chemistry (21.03.1997)
Published in The Journal of biological chemistry (21.03.1997)
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The Growth Factor Midkine Antagonizes VEGF Signaling In Vitro and In Vivo
van der Horst, Edward Htun, Frank, Brendon T., Chinn, Lawrence, Coxon, Angela, Li, Shyun, Polesso, Fanny, Slavin, Anthony, Ruefli-Brasse, Astrid, Wesche, Holger
Published in Neoplasia (New York, N.Y.) (01.04.2008)
Published in Neoplasia (New York, N.Y.) (01.04.2008)
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High throughput screening for protein kinase inhibitors
Wesche, Holger, Xiao, Shou-Hua, Young, Steve W
Published in Combinatorial chemistry & high throughput screening (01.03.2005)
Published in Combinatorial chemistry & high throughput screening (01.03.2005)
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Journal Article
Identification of Essential Regions in the Cytoplasmic Tail of Interleukin-1 Receptor Accessory Protein Critical for Interleukin-1 Signaling
Radons, Jürgen, Gabler, Stefan, Wesche, Holger, Korherr, Christian, Hofmeister, Robert, Falk, Werner
Published in The Journal of biological chemistry (10.05.2002)
Published in The Journal of biological chemistry (10.05.2002)
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