Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction
Hillig, Roman C., Sautier, Brice, Schroeder, Jens, Moosmayer, Dieter, Hilpmann, André, Stegmanna, Christian M., Werbeck, Nicolas D., Briem, Hans, Boemer, Ulf, Weiske, Joerg, Badock, Volker, Mastouri, Julia, Petersen, Kirstin, Siemeister, Gerhard, Kahmann, Jan D., Wegener, Dennis, Böhnke, Niels, Eis, Knut, Graham, Keith, Wortmann, Lars, von Nussbaum, Franz, Bader, Benjamin
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (12.02.2019)
Get full text
Journal Article
A distal regulatory region of a class I human histone deacetylase
Werbeck, Nicolas D, Shukla, Vaibhav Kumar, Kunze, Micha B A, Yalinca, Havva, Pritchard, Ruth B, Siemons, Lucas, Mondal, Somnath, Greenwood, Simon O R, Kirkpatrick, John, Marson, Charles M, Hansen, D Flemming
Published in Nature communications (31.07.2020)
Published in Nature communications (31.07.2020)
Get full text
Journal Article
Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction
Zeymer, Cathleen, Werbeck, Nicolas D., Zimmermann, Sabine, Reinstein, Jochen, Hansen, D. Flemming
Published in Angewandte Chemie (International ed.) (12.09.2016)
Published in Angewandte Chemie (International ed.) (12.09.2016)
Get full text
Journal Article
Probing Arginine Side-Chains and Their Dynamics with Carbon-Detected NMR Spectroscopy: Application to the 42 kDa Human Histone Deacetylase 8 at High pH
Werbeck, Nicolas D., Kirkpatrick, John, Hansen, D. Flemming
Published in Angewandte Chemie (International ed.) (11.03.2013)
Published in Angewandte Chemie (International ed.) (11.03.2013)
Get full text
Journal Article
The ATPase Cycle of the Mitochondrial Hsp90 Analog Trap1
Leskovar, Adriane, Wegele, Harald, Werbeck, Nicolas D., Buchner, Johannes, Reinstein, Jochen
Published in The Journal of biological chemistry (25.04.2008)
Published in The Journal of biological chemistry (25.04.2008)
Get full text
Journal Article
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target
Brzezinka, Krzysztof, Nevedomskaya, Ekaterina, Lesche, Ralf, Haegebarth, Andrea, Ter Laak, Antonius, Fernández-Montalván, Amaury E, Eberspaecher, Uwe, Werbeck, Nicolas D, Moenning, Ursula, Siegel, Stephan, Haendler, Bernard, Eheim, Ashley L, Stresemann, Carlo
Published in Cancers (14.01.2020)
Published in Cancers (14.01.2020)
Get full text
Journal Article
Coupling and Dynamics of Subunits in the Hexameric AAA+ Chaperone ClpB
Werbeck, Nicolas D., Schlee, Sandra, Reinstein, Jochen
Published in Journal of molecular biology (18.04.2008)
Published in Journal of molecular biology (18.04.2008)
Get full text
Journal Article
Loop Interactions and Dynamics Tune the Enzymatic Activity of the Human Histone Deacetylase 8
Kunze, Micha B. A, Wright, David W, Werbeck, Nicolas D, Kirkpatrick, John, Coveney, Peter V, Hansen, D. Flemming
Published in Journal of the American Chemical Society (27.11.2013)
Published in Journal of the American Chemical Society (27.11.2013)
Get full text
Journal Article
Identification of Small Molecules that Modulate Mutant p53 Condensation
Lemos, Clara, Schulze, Luise, Weiske, Joerg, Meyer, Hanna, Braeuer, Nico, Barak, Naomi, Eberspächer, Uwe, Werbeck, Nicolas, Stresemann, Carlo, Lange, Martin, Lesche, Ralf, Zablowsky, Nina, Juenemann, Katrin, Kamburov, Atanas, Luh, Laura Martina, Leissing, Thomas Markus, Mortier, Jeremie, Steckel, Michael, Steuber, Holger, Eis, Knut, Eheim, Ashley, Steigemann, Patrick
Published in iScience (25.09.2020)
Published in iScience (25.09.2020)
Get full text
Journal Article
Disaggregases in 4 dimensions
Barends, Thomas RM, Werbeck, Nicolas D, Reinstein, Jochen
Published in Current opinion in structural biology (01.02.2010)
Published in Current opinion in structural biology (01.02.2010)
Get full text
Journal Article
Coupling of Oligomerization and Nucleotide Binding in the AAA+ Chaperone ClpB
Werbeck, Nicolas D, Zeymer, Cathleen, Kellner, Julian N, Reinstein, Jochen
Published in Biochemistry (Easton) (08.02.2011)
Published in Biochemistry (Easton) (08.02.2011)
Get full text
Journal Article
Strategic Roles of Axial Histidines in Structure Formation and Redox Regulation of Tetraheme Cytochrome c3
TAKAYAMA, Yuki, WERBECK, Nicolas D., KOMORI, Hirofumi, MORITA, Kumiko, OZAWA, Kiyoshi, HIGUCHI, Yoshiki, AKUTSU, Hideo
Published in Biochemistry (Easton) (09.09.2008)
Published in Biochemistry (Easton) (09.09.2008)
Get full text
Journal Article
Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor
Zeymer, Cathleen, Barends, Thomas R. M., Werbeck, Nicolas D., Schlichting, Ilme, Reinstein, Jochen
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2014)
Published in Acta crystallographica. Section D, Biological crystallography. (01.02.2014)
Get full text
Journal Article
Strategic Roles of Axial Histidines in Structure Formation and Redox Regulation of Tetraheme Cytochrome c 3
Takayama, Yuki, Werbeck, Nicolas D, Komori, Hirofumi, Morita, Kumiko, Ozawa, Kiyoshi, Higuchi, Yoshiki, Akutsu, Hideo
Published in Biochemistry (Easton) (09.09.2008)
Published in Biochemistry (Easton) (09.09.2008)
Get full text
Journal Article