The glutamine transporter ASCT2 (SLC1A5) promotes tumor growth independently of the amino acid transporter LAT1 (SLC7A5)
Cormerais, Yann, Massard, Pierre André, Vucetic, Milica, Giuliano, Sandy, Tambutté, Eric, Durivault, Jerome, Vial, Valérie, Endou, Hitoshi, Wempe, Michael F., Parks, Scott K., Pouyssegur, Jacques
Published in The Journal of biological chemistry (23.02.2018)
Published in The Journal of biological chemistry (23.02.2018)
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l‐Type amino acid transporter 1 inhibitors inhibit tumor cell growth
Oda, Koji, Hosoda, Noriko, Endo, Hiroshi, Saito, Kunio, Tsujihara, Kenji, Yamamura, Michio, Sakata, Takeshi, Anzai, Naohiko, Wempe, Michael F., Kanai, Yoshikatsu, Endou, Hitoshi
Published in Cancer science (01.01.2010)
Published in Cancer science (01.01.2010)
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Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth
Cormerais, Yann, Giuliano, Sandy, LeFloch, Renaud, Front, Benoît, Durivault, Jerome, Tambutté, Eric, Massard, Pierre-André, de la Ballina, Laura Rodriguez, Endou, Hitoshi, Wempe, Michael F, Palacin, Manuel, Parks, Scott K, Pouyssegur, Jacques
Published in Cancer research (Chicago, Ill.) (01.08.2016)
Published in Cancer research (Chicago, Ill.) (01.08.2016)
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Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice
Andres-Hernando, Ana, Li, Nanxing, Cicerchi, Christina, Inaba, Shinichiro, Chen, Wei, Roncal-Jimenez, Carlos, Le, Myphuong T., Wempe, Michael F., Milagres, Tamara, Ishimoto, Takuji, Fini, Mehdi, Nakagawa, Takahiko, Johnson, Richard J., Lanaspa, Miguel A.
Published in Nature communications (13.02.2017)
Published in Nature communications (13.02.2017)
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Carnosine protects cardiac myocytes against lipid peroxidation products
Zhao, Jingjing, Posa, Dheeraj Kumar, Kumar, Vijay, Hoetker, David, Kumar, Amit, Ganesan, Smirthy, Riggs, Daniel W., Bhatnagar, Aruni, Wempe, Michael F., Baba, Shahid P.
Published in Amino acids (01.01.2019)
Published in Amino acids (01.01.2019)
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EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses
Ravindran Menon, Dinoop, Li, Yang, Yamauchi, Takeshi, Osborne, Douglas Grant, Vaddi, Prasanna Kumar, Wempe, Michael F, Zhai, Zili, Fujita, Mayumi
Published in Pharmaceuticals (Basel, Switzerland) (26.10.2021)
Published in Pharmaceuticals (Basel, Switzerland) (26.10.2021)
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Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma
Cormerais, Yann, Pagnuzzi‐Boncompagni, Marina, Schrötter, Sandra, Giuliano, Sandy, Tambutté, Eric, Endou, Hitoshi, Wempe, Michael F., Pagès, Gilles, Pouysségur, Jacques, Picco, Vincent
Published in Journal of cellular and molecular medicine (01.04.2019)
Published in Journal of cellular and molecular medicine (01.04.2019)
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Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy
Ferguson, Bradley S., Harrison, Brooke C., Jeong, Mark Y., Reid, Brian G., Wempe, Michael F., Wagner, Florence F., Holson, Edward B., McKinsey, Timothy A.
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (11.06.2013)
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Identification of a novel biomarker for pyridoxine‐dependent epilepsy: Implications for newborn screening
Wempe, Michael F., Kumar, Amit, Kumar, Vijay, Choi, Yu J., Swanson, Michael A., Friederich, Marisa W., Hyland, Keith, Yue, Wyatt W., Van Hove, Johan L. K., Coughlin, Curtis R.
Published in Journal of inherited metabolic disease (01.05.2019)
Published in Journal of inherited metabolic disease (01.05.2019)
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Retraction: In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats
Motohashi, Masaya, Wempe, Michael F., Mutou, Tomoko, Okayama, Yuya, Kansaku, Norio, Takahashi, Hiroyuki, Ikegami, Masahiro, Asari, Masao, Wakui, Shin
Published in Journal of toxicological sciences (2023)
Published in Journal of toxicological sciences (2023)
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Differential High-Affinity Interaction of Dectin-1 with Natural or Synthetic Glucans Is Dependent upon Primary Structure and Is Influenced by Polymer Chain Length and Side-Chain Branching
Adams, Elizabeth L, Rice, Peter J, Graves, Bridget, Ensley, Harry E, Yu, Hai, Brown, Gordon D, Gordon, Siamon, Monteiro, Mario A, Papp-Szabo, Erzsebet, Lowman, Douglas W, Power, Trevor D, Wempe, Michael F, Williams, David L
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2008)
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Human Sodium Phosphate Transporter 4 (hNPT4/SLC17A3) as a Common Renal Secretory Pathway for Drugs and Urate
Jutabha, Promsuk, Anzai, Naohiko, Kitamura, Kenichiro, Taniguchi, Atsuo, Kaneko, Shuji, Yan, Kunimasa, Yamada, Hideomi, Shimada, Hidetaka, Kimura, Toru, Katada, Tomohisa, Fukutomi, Toshiyuki, Tomita, Kimio, Urano, Wako, Yamanaka, Hisashi, Seki, George, Fujita, Toshiro, Moriyama, Yoshinori, Yamada, Akira, Uchida, Shunya, Wempe, Michael F., Endou, Hitoshi, Sakurai, Hiroyuki
Published in The Journal of biological chemistry (05.11.2010)
Published in The Journal of biological chemistry (05.11.2010)
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Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury
Zhao, Jingjing, Conklin, Daniel J, Guo, Yiru, Zhang, Xiang, Obal, Detlef, Guo, Luping, Jagatheesan, Ganapathy, Katragadda, Kartik, He, Liqing, Yin, Xinmin, Prodhan, Md Aminul Islam, Shah, Jasmit, Hoetker, David, Kumar, Amit, Kumar, Vijay, Wempe, Michael F, Bhatnagar, Aruni, Baba, Shahid P
Published in Journal of the American Heart Association (16.06.2020)
Published in Journal of the American Heart Association (16.06.2020)
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HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Koneru, Pratibha C, Francis, Ashwanth C, Deng, Nanjie, Rebensburg, Stephanie V, Hoyte, Ashley C, Lindenberger, Jared, Adu-Ampratwum, Daniel, Larue, Ross C, Wempe, Michael F, Engelman, Alan N, Lyumkis, Dmitry, Fuchs, James R, Levy, Ronald M, Melikyan, Gregory B, Kvaratskhelia, Mamuka
Published in eLife (23.05.2019)
Published in eLife (23.05.2019)
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Journal Article
In utero-exposed di(n-butyl) phthalate induce dose dependent, age-related changes of morphology and testosterone-biosynthesis enzymes/associated proteins of Leydig cell mitochondria in rats
Motohashi, Masaya, Wempe, Michael F, Mutou, Tomoko, Okayama, Yuya, Kansaku, Norio, Takahashi, Hiroyuki, Ikegami, Masahiro, Asari, Masao, Wakui, Shin
Published in Journal of toxicological sciences (01.04.2016)
Published in Journal of toxicological sciences (01.04.2016)
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Liquid chromatography–mass spectrometry/mass spectrometry method development for drug metabolism studies: Examining lipid matrix ionization effects in plasma
Little, James L., Wempe, Michael F., Buchanan, Charles M.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (03.04.2006)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (03.04.2006)
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Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound
Wempe, Michael F., Rice, Peter J., Lightner, Janet W., Jutabha, Promsuk, Hayashi, Michinari, Anzai, Naohiko, Wakui, Shin, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Endou, Hitoshi
Published in DRUG METABOLISM AND PHARMACOKINETICS (2012)
Published in DRUG METABOLISM AND PHARMACOKINETICS (2012)
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JPH203, an L-Type Amino Acid Transporter 1–Selective Compound, Induces Apoptosis of YD-38 Human Oral Cancer Cells
Yun, Dae-Woong, Lee, Seul Ah, Park, Min-Gyeong, Kim, Jae-Sung, Yu, Sun-Kyoung, Park, Mi-Ra, Kim, Su-Gwan, Oh, Ji-Su, Kim, Chun Sung, Kim, Heung-Joong, Kim, Jin-Soo, Chun, Hong Sung, Kanai, Yoshikatsu, Endou, Hitoshi, Wempe, Michael F., Kim, Do Kyung
Published in Journal of Pharmacological Sciences (2014)
Published in Journal of Pharmacological Sciences (2014)
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JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells
Choi, Dae Woo, Kim, Do Kyung, Kanai, Yoshikatsu, Wempe, Michael F, Endou, Hitoshi, Kim, Jong-Keun
Published in The Korean journal of physiology & pharmacology (01.11.2017)
Published in The Korean journal of physiology & pharmacology (01.11.2017)
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Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells
Dosier, Laura Beth Mann, Premkumar, Vikram J, Zhu, Hongmei, Akosman, Izzet, Wempe, Michael F, McMahon, Timothy J
Published in Thrombosis and haemostasis (2017)
Published in Thrombosis and haemostasis (2017)
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