Search Results - "WELLS-KNECHT, KEVIN, J" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors

Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors

by Mesaros, Eugen F, Thieu, Tho V, Wells, Gregory J, Zificsak, Craig A, Wagner, Jason C, Breslin, Henry J, Tripathy, Rabindranath, Diebold, James L, McHugh, Robert J, Wohler, Ashley T, Quail, Matthew R, Wan, Weihua, Lu, Lihui, Huang, Zeqi, Albom, Mark S, Angeles, Thelma S, Wells-Knecht, Kevin J, Aimone, Lisa D, Cheng, Mangeng, Ator, Mark A, Ott, Gregory R, Dorsey, Bruce D
Published in Journal of medicinal chemistry (12.01.2012)

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Characterization of a Stable 2,2′-Azobis(2-Methylpropanenitrile) Degradant and Its Use to Monitor the Oxidative Environment During Forced Degradation Studies by Liquid Chromatography/Mass Spectrometry

Characterization of a Stable 2,2′-Azobis(2-Methylpropanenitrile) Degradant and Its Use to Monitor the Oxidative Environment During Forced Degradation Studies by Liquid Chromatography/Mass Spectrometry

by Wells-Knecht, Kevin J., Dunn, Derek
Published in Journal of pharmaceutical sciences (01.09.2019)

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Glycation, glycoxidation, and cross-linking of collagen by glucose : kinetics, mechanisms, and inhibition of late stages of the Maillard reaction

Glycation, glycoxidation, and cross-linking of collagen by glucose : kinetics, mechanisms, and inhibition of late stages of the Maillard reaction

by MIN-XIN FU, WELLS-KENCHT, K. J, BLACKLEDGE, J. A, LYONS, T. J, THORPE, S. R, BAYNES, J. W
Published in Diabetes (New York, N.Y.) (01.05.1994)

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A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779

A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-a]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779

by Dugan, Benjamin J, Gingrich, Diane E, Mesaros, Eugen F, Milkiewicz, Karen L, Curry, Matthew A, Zulli, Allison L, Dobrzanski, Pawel, Serdikoff, Cynthia, Jan, Mahfuza, Angeles, Thelma S, Albom, Mark S, Mason, Jennifer L, Aimone, Lisa D, Meyer, Sheryl L, Huang, Zeqi, Wells-Knecht, Kevin J, Ator, Mark A, Ruggeri, Bruce A, Dorsey, Bruce D
Published in Journal of medicinal chemistry (14.06.2012)

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Design, Synthesis, and Anaplastic Lymphoma Kinase (ALK) Inhibitory Activity for a Novel Series of 2,4,8,22-Tetraazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene Macrocycles

Design, Synthesis, and Anaplastic Lymphoma Kinase (ALK) Inhibitory Activity for a Novel Series of 2,4,8,22-Tetraazatetracyclo[14.3.1.13,7.19,13]docosa-1(20),3(22),4,6,9(21),10,12,16,18-nonaene Macrocycles

by Breslin, Henry J, Lane, Brandon M, Ott, Gregory R, Ghose, Arup K, Angeles, Thelma S, Albom, Mark S, Cheng, Mangeng, Wan, Weihua, Haltiwanger, R. Curtis, Wells-Knecht, Kevin J, Dorsey, Bruce D
Published in Journal of medicinal chemistry (12.01.2012)

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2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

2,7-Pyrrolo[2,1- f][1,2,4]triazines as JAK2 inhibitors: Modification of target structure to minimize reactive metabolite formation

by Weinberg, Linda R., Albom, Mark S., Angeles, Thelma S., Breslin, Henry J., Gingrich, Diane E., Huang, Zeqi, Lisko, Joseph G., Mason, Jennifer L., Milkiewicz, Karen L., Thieu, Tho V., Underiner, Ted L., Wells, Gregory J., Wells-Knecht, Kevin J., Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)

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2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation

2,7-Disubstituted-Pyrrolotriazine Kinase Inhibitors with an Unusually High Degree of Reactive Metabolite Formation

by Wells-Knecht, Kevin J, Ott, Gregory R, Cheng, Mangeng, Wells, Gregory J, Breslin, Henry J, Gingrich, Diane E, Weinberg, Linda, Mesaros, Eugen F, Huang, Zeqi, Yazdanian, Mehran, Ator, Mark A, Aimone, Lisa D, Zeigler, Kelli, Dorsey, Bruce D
Published in Chemical research in toxicology (21.11.2011)

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2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

2,4-Diaminopyrimidine inhibitors of c-Met kinase bearing benzoxazepine anilines

by Zificsak, Craig A., Theroff, Jay P., Aimone, Lisa D., Albom, Mark S., Angeles, Thelma S., Brown, Rebecca A., Galinis, Deborah, Grobelny, Jennifer V., Herbertz, Torsten, Husten, Jean, Kocsis, Laura S., LoSardo, Christine, Miknyoczki, Sheila J., Murthy, Seetha, Rolon-Steele, Damaris, Underiner, Ted L., Wells-Knecht, Kevin J., Worrell, Candace S., Zeigler, Kelli S., Dorsey, Bruce D.
Published in Bioorganic & medicinal chemistry letters (15.01.2011)

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3-Deoxyfructose concentrations are increased in human plasma and urine in diabetes

3-Deoxyfructose concentrations are increased in human plasma and urine in diabetes

by WELLS-KNECHT, K. J, LYONS, T. J, MCCANCE, D. R, THORPE, S. R, FEATHER, M. S, BAYNES, J. W
Published in Diabetes (New York, N.Y.) (01.09.1994)

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Modification of CellSensor irf1-bla TF-1 and irf1-bla HEL assays for direct comparison of wild-type JAK2 and JAK2 V617F inhibition

Modification of CellSensor irf1-bla TF-1 and irf1-bla HEL assays for direct comparison of wild-type JAK2 and JAK2 V617F inhibition

by Mason, Jennifer L, Holskin, Beverly P, Murray, Kristen A, Meyer, Sheryl L, Wells-Knecht, Kevin J, Ator, Mark A, Angeles, Thelma S
Published in Assay and drug development technologies (01.06.2011)

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Characterization of an Imidazolium Salt Formed from Glyoxal and N.alpha.-Hippuryllysine: A Model for Maillard Reaction Crosslinks in Proteins

Characterization of an Imidazolium Salt Formed from Glyoxal and N.alpha.-Hippuryllysine: A Model for Maillard Reaction Crosslinks in Proteins

by Wells-Knecht, Kevin J, Brinkmann, Elisabeth, Baynes, John W
Published in Journal of organic chemistry (01.10.1995)

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Acyclic, orally bioavailable ketone-based cathepsin K inhibitors

Acyclic, orally bioavailable ketone-based cathepsin K inhibitors

by Barrett, David G., Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Samano, Vicente, Tavares, Francis X., Wells-Knecht, Kevin J., Wright, Lois L., Zhou, Hui-Qiang Q.
Published in Bioorganic & medicinal chemistry letters (2007)

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Design of small molecule ketoamide-based inhibitors of cathepsin K

Design of small molecule ketoamide-based inhibitors of cathepsin K

by Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Larry R., Payne, J.Alan, Wells-Knecht, Kevin J., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (09.02.2004)

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A structural screening approach to ketoamide-based inhibitors of cathepsin K

A structural screening approach to ketoamide-based inhibitors of cathepsin K

by Barrett, David G., Catalano, John G., Deaton, David N., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Wells-Knecht, Kevin J., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)

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Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose

Identification of Glyoxal and Arabinose as Intermediates in the Autoxidative Modification of Proteins by Glucose

by Wells-Knecht, Kevin J, Zyzak, David V, Litchfield, John E, Thorpe, Suzanne R, Baynes, John W
Published in Biochemistry (Easton) (21.03.1995)

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Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?

Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?

by Adkison, Kim K., Barrett, David G., Deaton, David N., Gampe, Robert T., Hassell, Anne M., Long, Stacey T., McFadyen, Robert B., Miller, Aaron B., Miller, Larry R., Payne, J. Alan, Shewchuk, Lisa M., Wells-Knecht, Kevin J., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.02.2006)

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Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K

Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K

by Barrett, David G., Catalano, John G., Deaton, David N., Long, Stacey T., Miller, Larry R., Tavares, Francis X., Wells-Knecht, Kevin J., Wright, Lois L., Zhou, Hui-Qiang Q.
Published in Bioorganic & medicinal chemistry letters (17.05.2004)

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Novel, potent P2–P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

Novel, potent P2–P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors

by Barrett, David G., Catalano, John G., Deaton, David N., Hassell, Anne M., Long, Stacey T., Miller, Aaron B., Miller, Larry R., Ray, John A., Samano, Vicente, Shewchuk, Lisa M., Wells-Knecht, Kevin J., Willard, Derril H., Wright, Lois L.
Published in Bioorganic & medicinal chemistry letters (15.03.2006)

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Aminoguanidine and the Effects of Modified LDL on Cultured Retinal Capillary Cells

Aminoguanidine and the Effects of Modified LDL on Cultured Retinal Capillary Cells

by Lyons, Timothy J, Li, Wei, Wojciechowski, Barbara, Wells-Knecht, Mary C, Wells-Knecht, Kevin J, Jenkins, Alicia J
Published in Investigative ophthalmology & visual science (01.04.2000)

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P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

by BARRETT, David G, BONCEK, Virginia M, PAYNE, J. Alan, RAY, John A, SAMANO, Vicente, SHEWCHUK, Lisa M, TAVARES, Francis X, WELLS-KNECHT, Kevin J, WILLARD, Derril H, WRIGHT, Lois L, ZHOU, Hui-Qiang Q, CATALANO, John G, DEATON, David N, HASSELL, Anne M, JURGENSEN, Cynthia H, LONG, Stacey T, MCFADYEN, Robert B, MILLER, Aaron B, MILLER, Larry R
Published in Bioorganic & medicinal chemistry letters (01.08.2005)

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