Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)
Hobson, Adrian D., Xu, Jianwen, Welch, Dennie S., Marvin, Christopher C., McPherson, Michael J., Gates, Bradley, Liao, Xiaoli, Hollmann, Markus, Gattner, Michael J., Dzeyk, Kristina, Sarvaiya, Hetal, Shenoy, Vikram M., Fettis, Margaret M., Bischoff, Agnieszka K., Wang, Lu, Santora, Ling C., Wang, Lu, Fitzgibbons, Julia, Salomon, Paulin, Hernandez, Axel, Jia, Ying, Goess, Christian A., Mathieu, Suzanne L., Bryant, Shaughn H., Larsen, Mary E., Cui, Baoliang, Tian, Yu
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses
Amberg, Alexander, Beilke, Lisa, Bercu, Joel, Bower, Dave, Brigo, Alessandro, Cross, Kevin P., Custer, Laura, Dobo, Krista, Dowdy, Eric, Ford, Kevin A., Glowienke, Susanne, Van Gompel, Jacky, Harvey, James, Hasselgren, Catrin, Honma, Masamitsu, Jolly, Robert, Kemper, Raymond, Kenyon, Michelle, Kruhlak, Naomi, Leavitt, Penny, Miller, Scott, Muster, Wolfgang, Nicolette, John, Plaper, Andreja, Powley, Mark, Quigley, Donald P., Reddy, M. Vijayaraj, Spirkl, Hans-Peter, Stavitskaya, Lidiya, Teasdale, Andrew, Weiner, Sandy, Welch, Dennie S., White, Angela, Wichard, Joerg, Myatt, Glenn J.
Published in Regulatory toxicology and pharmacology (01.06.2016)
Published in Regulatory toxicology and pharmacology (01.06.2016)
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Development of a Large-Scale Route to Glecaprevir: Synthesis of the Macrocycle via Intramolecular Etherification
Kallemeyn, Jeffrey M, Engstrom, Kenneth M, Pelc, Matthew J, Lukin, Kirill A, Morrill, Westin H, Wei, Haojuan, Towne, Timothy B, Henle, Jeremy, Nere, Nandkishor K, Welch, Dennie S, Shekhar, Shashank, Ravn, Matthew M, Zhao, Gang, Fickes, Michael G, Ding, Chen, Vinci, John C, Marren, James, Cink, Russell D
Published in Organic process research & development (21.08.2020)
Published in Organic process research & development (21.08.2020)
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Principles and procedures for handling out-of-domain and indeterminate results as part of ICH M7 recommended (Q)SAR analyses
Amberg, Alexander, Andaya, Roxanne V., Anger, Lennart T., Barber, Chris, Beilke, Lisa, Bercu, Joel, Bower, Dave, Brigo, Alessandro, Cammerer, Zoryanna, Cross, Kevin P., Custer, Laura, Dobo, Krista, Gerets, Helga, Gervais, Véronique, Glowienke, Susanne, Gomez, Stephen, Van Gompel, Jacky, Harvey, James, Hasselgren, Catrin, Honma, Masamitsu, Johnson, Candice, Jolly, Robert, Kemper, Raymond, Kenyon, Michelle, Kruhlak, Naomi, Leavitt, Penny, Miller, Scott, Muster, Wolfgang, Naven, Russell, Nicolette, John, Parenty, Alexis, Powley, Mark, Quigley, Donald P., Reddy, M. Vijayaraj, Sasaki, Jennifer C., Stavitskaya, Lidiya, Teasdale, Andrew, Trejo-Martin, Alejandra, Weiner, Sandy, Welch, Dennie S., White, Angela, Wichard, Joerg, Woolley, David, Myatt, Glenn J.
Published in Regulatory toxicology and pharmacology (01.03.2019)
Published in Regulatory toxicology and pharmacology (01.03.2019)
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A Kinetics-Based Approach for the Assignment of Reactivity Purge Factors
Betori, Rick C, Kallemeyn, Jeffrey M, Welch, Dennie S
Published in Organic process research & development (20.11.2015)
Published in Organic process research & development (20.11.2015)
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Journal Article
New Semi-Automated Computer-Based System for Assessing the Purge of Mutagenic Impurities
Burns, Michael J, Ott, Martin A, Teasdale, Andrew, Stalford, Susanne A, Antonucci, Vincent, Baumann, Jens-Christoph, Brown, Roland, Covey-Crump, Elizabeth M, Elder, David, Elliott, Eric, Fennell, Jared W, Gallou, Fabrice, Ide, Nathan D, Itoh, Tetsuji, Jordine, Guido, Kallemeyn, Jeffrey M, Lauwers, Dirk, Looker, Adam R, Lovelle, Lucie E, Molzahn, Robert, Schils, Didier, Schulte Oestrich, Rolf, Sluggett, Gregory W, Stevenson, Neil, Talavera, Pere, Urquhart, Michael W, Varie, David L, Welch, Dennie S
Published in Organic process research & development (15.11.2019)
Published in Organic process research & development (15.11.2019)
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Asymmetric Synthesis of a TRPV1 Antagonist via tert-Butanesulfinamide-Directed Reductive Amination with a Chromanone
Bellizzi, Mary E, Bhatia, Ashok V, Cullen, Steven C, Gandarilla, Jorge, Kruger, Albert W, Welch, Dennie S
Published in Organic process research & development (21.02.2014)
Published in Organic process research & development (21.02.2014)
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Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters
Keck, Gary E, Poudel, Yam B, Welch, Dennie S, Kraft, Matthew B, Truong, Anh P, Stephens, Jeffrey C, Kedei, Noemi, Lewin, Nancy E, Blumberg, Peter M
Published in Organic letters (05.02.2009)
Published in Organic letters (05.02.2009)
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Journal Article
Development and Execution of a Scalable Route to an Immunology ADC Drug-Linker for ABBV-154
Bennett, Nathan B., Shen, Xiaoqiang, Gates, Bradley D., Welch, Dennie S., Servos, Mark A., Simanis, Justin A., Ellis, Ryan G., Qiu, Haixiao, Moschetta, Eric G., Feng, Jiajie, Boukerche, Moussa, Rasmussen, Michael, McKee, Laura A., Mlinar, Laurie B., Chen, Shuang, Wang, Zhe
Published in Organic process research & development (19.07.2024)
Published in Organic process research & development (19.07.2024)
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Journal Article
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker
Bennett, Nathan B., Mlinar, Laurie B., Moschetta, Eric G., Ellis, Ryan G., Chung, Ryan, Manjrekar, Onkar, Rasmussen, Michael, McKee, Laura A., Servos, Mark A., Simanis, Justin A., Gates, Bradley D., Shen, Xiaoqiang, Welch, Dennie S., Wang, Zhe
Published in Organic process research & development (19.07.2024)
Published in Organic process research & development (19.07.2024)
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Journal Article
BCL XL BCL XL INHIBITORY COMPOUNDS HAVING LOW CELL PERMEABILITY AND ANTIBODY DRUG CONJUGATES INCLUDING THE SAME
CULLEN STEVE C, WELCH DENNIE S, SONG XIAOHONG, BENNETT NATHAN B, DOHERTY GEORGE, BOGHAERT ERWIN R, SULLIVAN GERARD M, MARIN VIOLETA L, SOUERS ANDREW J, WANG XILU, TAO ZHI FU, SHEN XIAOQIANG, WENDT MICHAEL D, HAIGHT ANTHONY R, KUNZER AARON R, FREY ROBIN R, ACKLER SCOTT L, JUDD ANDREW S
Year of Publication 16.08.2017
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Year of Publication 16.08.2017
Patent
5 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
WELCH DENNIE S, ZHAO HONGYU, WILSON NOEL S, BRAJE WILFRIED, RELO ANA LUCIA, THOMPSON CHRISTINA M, TURNER SEAN C, KRUGER ALBERT W, SHEKHAR SHASHANK, LI HUANQIU, ZHANG MIN, GASIECKI ALAN F, AKRITOPOULOU ZANZE IRINI, DJURIC STEVAN W, GANDARILLA JORGE
Year of Publication 02.09.2013
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Year of Publication 02.09.2013
Patent
MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
WELCH DENNIE S, ZHAO HONGYU, WILSON NOEL S, BRAJE WILFRIED, RELO ANA LUCIA, THOMPSON CHRISTINA M, TURNER SEAN C, KRUGER ALBERT W, SHEKHAR SHASHANK, LI HUANQIU, ZHANG MIN, GASIECKI ALAN F, AKRITOPOULOU ZANZE IRINI, DJURIC STEVAN W, GANDARILLA JORGE
Year of Publication 12.06.2012
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Year of Publication 12.06.2012
Patent