The physiological interactome of TCR-like antibody therapeutics in human tissues
Marrer-Berger, Estelle, Nicastri, Annalisa, Augustin, Angelique, Kramar, Vesna, Liao, Hanqing, Hanisch, Lydia Jasmin, Carpy, Alejandro, Weinzierl, Tina, Durr, Evelyne, Schaub, Nathalie, Nudischer, Ramona, Ortiz-Franyuti, Daniela, Breous-Nystrom, Ekaterina, Stucki, Janick, Hobi, Nina, Raggi, Giulia, Cabon, Lauriane, Lezan, Emmanuelle, Umaña, Pablo, Woodhouse, Isaac, Bujotzek, Alexander, Klein, Christian, Ternette, Nicola
Published in Nature communications (16.04.2024)
Published in Nature communications (16.04.2024)
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Pharmacokinetics and Pharmacodynamics of T-Cell Bispecifics in the Tumour Interstitial Fluid
Eigenmann, Miro Julian, Karlsen, Tine Veronica, Wagner, Marek, Tenstad, Olav, Weinzierl, Tina, Fauti, Tanja, Grimm, Hans Peter, Skogstrand, Trude, Klein, Christian, Sam, Johannes, Umana, Pablo, Bacac, Marina, Wiig, Helge, Walz, Antje-Christine
Published in Pharmaceutics (07.12.2021)
Published in Pharmaceutics (07.12.2021)
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A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
Bacac, Marina, Fauti, Tanja, Sam, Johannes, Colombetti, Sara, Weinzierl, Tina, Ouaret, Djamila, Bodmer, Walter, Lehmann, Steffi, Hofer, Thomas, Hosse, Ralf J, Moessner, Ekkehard, Ast, Oliver, Bruenker, Peter, Grau-Richards, Sandra, Schaller, Teilo, Seidl, Annette, Gerdes, Christian, Perro, Mario, Nicolini, Valeria, Steinhoff, Nathalie, Dudal, Sherri, Neumann, Sebastian, von Hirschheydt, Thomas, Jaeger, Christiane, Saro, Jose, Karanikas, Vaios, Klein, Christian, Umaña, Pablo
Published in Clinical cancer research (01.07.2016)
Published in Clinical cancer research (01.07.2016)
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Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models
Herter, Sylvia, Herting, Frank, Mundigl, Olaf, Waldhauer, Inja, Weinzierl, Tina, Fauti, Tanja, Muth, Gunter, Ziegler-Landesberger, Doris, Van Puijenbroek, Erwin, Lang, Sabine, Duong, Minh Ngoc, Reslan, Lina, Gerdes, Christian A, Friess, Thomas, Baer, Ute, Burtscher, Helmut, Weidner, Michael, Dumontet, Charles, Umana, Pablo, Niederfellner, Gerhard, Bacac, Marina, Klein, Christian
Published in Molecular cancer therapeutics (01.10.2013)
Published in Molecular cancer therapeutics (01.10.2013)
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A Novel Approach for Quantifying the Pharmacological Activity of T-Cell Engagers Utilizing In Vitro Time Course Experiments and Streamlined Data Analysis
Van De Vyver, Arthur, Eigenmann, Miro, Ovacik, Meric, Pohl, Christian, Herter, Sylvia, Weinzierl, Tina, Fauti, Tanja, Klein, Christian, Lehr, Thorsten, Bacac, Marina, Walz, Antje-Christine
Published in The AAPS journal (03.12.2021)
Published in The AAPS journal (03.12.2021)
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Predicting Tumor Killing and T-Cell Activation by T-Cell Bispecific Antibodies as a Function of Target Expression: Combining In Vitro Experiments with Systems Modeling
Van De Vyver, Arthur J, Weinzierl, Tina, Eigenmann, Miro J, Frances, Nicolas, Herter, Sylvia, Buser, Regula B, Somandin, Jitka, Diggelmann, Sarah, Limani, Florian, Lehr, Thorsten, Bacac, Marina, Walz, Antje-Christine
Published in Molecular cancer therapeutics (01.02.2021)
Published in Molecular cancer therapeutics (01.02.2021)
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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies
Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane
Published in eLife (11.08.2021)
Published in eLife (11.08.2021)
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T BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
BACAC MARINA, JAEGER CHRISTIANE, HOFER THOMAS, KLEIN CHRISTIAN, UMANA PABLO, WEINZIERL TINA, HOSSE RALF, MOESSNER EKKEHARD
Year of Publication 29.07.2021
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Year of Publication 29.07.2021
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XGFR, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cancer
Schanzer, Juergen M, Wartha, Katharina, Moessner, Ekkehard, Hosse, Ralf J, Moser, Samuel, Croasdale, Rebecca, Trochanowska, Halina, Shao, Cuiying, Wang, Peng, Shi, Lei, Weinzierl, Tina, Rieder, Natascha, Bacac, Marina, Ries, Carola H, Kettenberger, Hubert, Schlothauer, Tilman, Friess, Thomas, Umana, Pablo, Klein, Christian
Published in mAbs (18.05.2016)
Published in mAbs (18.05.2016)
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BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
PETER BRUENKER, KLEIN CHRISTIAN, MARINA BACAC, WEINZIERL TINA, CHRISTIANE JAEGER, MOESSNER EKKEHARD, PABLO UMANA
Year of Publication 24.12.2020
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Year of Publication 24.12.2020
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Abstract 2955: Herceptarg, a novel heterodimeric biparatopic common light chain IgG1 antibody based on trastuzumab and pertuzumab, exerts potent anti-tumoral activity
Moessner, Ekkehard, Hofer, Thomas, Waldhauer, Inja, Scheuer, Werner, Hosse, Ralf, Duerner, Lydia, He, Mi, Zick, Karlheinz, Fischer, Jens, Sustmann, Claudio, Weinzierl, Tina, Bacac, Marina, Gerdes, Christian, Umana, Pablo, Klein, Christian
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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HLA-A2/MAGE-A4에 결합하는 항체
HANISCH LYDIA JASMIN, MARRER BERGER ESTELLE, CARPY GUTIERREZ CIRLOS ALEJANDRO, KLEIN CHRISTIAN, FAUTI TANJA, WEINZIERL TINA, KLOSTERMANN STEFAN, UMANA PABLO, BUJOTZEK ALEXANDER, KEISER SIMON PATRICK
Year of Publication 18.07.2022
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Year of Publication 18.07.2022
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Abstract 3629: Engineering a novel asymmetric head-to-tail 2+1 T-cell bispecific (2+1 TCB) IgG antibody platform with superior T-cell killing compared to 1+1 asymmetric TCBs
Klein, Christian, Neumann, Christiane, Fauti, Tanja, Weinzierl, Tina, Freimoser-Grundschober, Anne, Waldhauer, Inja, Fahrni, Linda, Herter, Sylvia, Puijenbroek, Erwin van, Colombetti, Sara, Sam, Johannes, Lang, Sabine, Dudal, Sherri, Schäfer, Wolfgang, Regula, Jörg T., Moser, Samuel, Ast, Oliver, Hosse, Ralf, Mössner, Ekkehard, Brünker, Peter, Bacac, Marina, Umana, Pablo
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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T BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
BACAC MARINA, JAEGER CHRISTIANE, HOFER THOMAS, KLEIN CHRISTIAN, UMANA PABLO, WEINZIERL TINA, HOSSE RALF, MOESSNER EKKEHARD
Year of Publication 26.03.2020
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Year of Publication 26.03.2020
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STEAP-1에 결합하는 항체
LARIVIERE LAURENT, HOFER THOMAS, KOENIG MAXIMILIANE, NIEWOEHNER JENS, WEINZIERL TINA, MOESSNER EKKEHARD
Year of Publication 09.12.2019
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Year of Publication 09.12.2019
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BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
PETER BRUENKER, KLEIN CHRISTIAN, MARINA BACAC, WEINZIERL TINA, CHRISTIANE JAEGER, MOESSNER EKKEHARD, PABLO UMANA
Year of Publication 15.08.2019
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Year of Publication 15.08.2019
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A New Class of T-Cell Bispecific Antibodies for the Treatment of Multiple Myeloma, Binding to B Cell Maturation Antigen and CD3 and Showing Potent, Specific Antitumor Activity in Myeloma Cells and Long Duration of Action in Cynomolgus Monkeys
Vu, Minh Diem, Moser, Samuel, Delon, Camille, Latzko, Melanie, Gianotti, Reto, Lüoend, Remo, Friang, Chloé, Murr, Ramona, Duerner, Lydia Jasmin, Weinzierl, Tina, Fauti, Tanja, Bacac, Marina, Ast, Oliver, Freimoser-Grundschober, Anne, Rodriguez Diaz, Tea, Zielonka, Jörg, van Puijenbroek, Erwin, Hosse, Ralf, Bruenker, Peter, Mössner, Ekkehard, Klein, Christian, Umaña, Pablo, Strein, Klaus
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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T BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
BACAC MARINA, JAEGER CHRISTIANE, HOFER THOMAS, KLEIN CHRISTIAN, UMANA PABLO, WEINZIERL TINA, HOSSE RALF, MOESSNER EKKEHARD
Year of Publication 06.03.2018
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Year of Publication 06.03.2018
Patent
BISPECIFIC T CELL ACTIVATING ANTIGEN BINDING MOLECULES
BACAC MARINA, JAEGER CHRISTIANE, BRUENKER PETER, KLEIN CHRISTIAN, UMANA PABLO, WEINZIERL TINA, MOESSNER EKKEHARD
Year of Publication 02.11.2015
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Year of Publication 02.11.2015
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