Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
Liu, Xingrong, Vilenski, Olga, Kwan, Joyce, Apparsundaram, Subbu, Weikert, Robert
Published in Drug metabolism and disposition (01.07.2009)
Published in Drug metabolism and disposition (01.07.2009)
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2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression
Carter, David S., Cai, Hai-Ying, Lee, Eun Kyung, Iyer, Pravin S., Lucas, Matthew C., Roetz, Ralf, Schoenfeld, Ryan C., Weikert, Robert J.
Published in Bioorganic & medicinal chemistry letters (01.07.2010)
Published in Bioorganic & medicinal chemistry letters (01.07.2010)
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Design, synthesis, and biological evaluation of new monoamine reuptake inhibitors with potential therapeutic utility in depression and pain
Lucas, Matthew C., Weikert, Robert J., Carter, David S., Cai, Hai-Ying, Greenhouse, Robert, Iyer, Pravin S., Lin, Clara J., Lee, Eun Kyung, Madera, Ann Marie, Moore, Amy, Ozboya, Kerem, Schoenfeld, Ryan C., Steiner, Sandra, Zhai, Yansheng, Lynch, Stephen M.
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
Published in Bioorganic & medicinal chemistry letters (15.09.2010)
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Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors
BANNWART, Linda M, CARTER, David S, LYNCH, Stephen M, MADERA, Ann Marie, MOORE, Amy, OZBOYA, Kerem, RAPTOVA, Lubica, ROETZ, Ralf, SCHOENFELD, Ryan C, STEIN, Karin Ann, STEINER, Sandra, VILLA, Marzia, CAI, Hai-Ying, WEIKERT, Robert J, YANSHENG ZHAI, CHOY, Jason C, GREENHOUSE, Robert, JAIME-FIGUEROA, Saul, LYER, Pravin S, LIN, Clara J, EUN KYUNG LEE, LUCAS, Matthew C
Published in Bioorganic & medicinal chemistry (01.12.2008)
Published in Bioorganic & medicinal chemistry (01.12.2008)
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Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors
Lucas, Matthew C., Carter, David S., Cai, Hai-Ying, Lee, Eun Kyung, Schoenfeld, Ryan C., Steiner, Sandra, Villa, Marzia, Weikert, Robert J., Iyer, Pravin S.
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
Published in Bioorganic & medicinal chemistry letters (15.08.2009)
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Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial
Sahni, Jayashree, Patel, Sunil S, Dugel, Pravin U, Khanani, Arshad M, Jhaveri, Chirag D, Wykoff, Charles C, Hershberger, Vrinda S, Pauly-Evers, Meike, Sadikhov, Shamil, Szczesny, Piotr, Schwab, Dietmar, Nogoceke, Everson, Osborne, Aaron, Weikert, Robert, Fauser, Sascha
Published in Ophthalmology (Rochester, Minn.) (01.08.2019)
Published in Ophthalmology (Rochester, Minn.) (01.08.2019)
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Safety and Efficacy of Different Doses and Regimens of Faricimab vs Ranibizumab in Neovascular Age-Related Macular Degeneration: The AVENUE Phase 2 Randomized Clinical Trial
Sahni, Jayashree, Dugel, Pravin U, Patel, Sunil S, Chittum, Mark E, Berger, Brian, Del Valle Rubido, Marta, Sadikhov, Shamil, Szczesny, Piotr, Schwab, Dietmar, Nogoceke, Everson, Weikert, Robert, Fauser, Sascha
Published in JAMA ophthalmology (01.09.2020)
Published in JAMA ophthalmology (01.09.2020)
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326-OR: Faricimab for Diabetic Macular Edema: A Novel Anti–Angiopoietin-2/Anti–Vascular Endothelial Growth Factor Bispecific Antibody in Clinical Trials
SHETH, VEERAL, SAHNI, JAYASHREE, STOILOV, IVAYLO, WILLIS, JEFFREY R., WEIKERT, ROBERT
Published in Diabetes (New York, N.Y.) (01.06.2020)
Published in Diabetes (New York, N.Y.) (01.06.2020)
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Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action
Han, Xingchun, Zhou, Chengang, Jiang, Min, Wang, Yongguang, Wang, Jianhua, Cheng, Zhanling, Wang, Min, Liu, Yongqiang, Liang, Chungen, Wang, Jianping, Wang, Zhanguo, Weikert, Robert, Lv, Wenzhe, Xie, Jianxun, Yu, Xin, Zhou, Xue, Luangsay, Souphalone, Shen, Hong C, Mayweg, Alexander V, Javanbakht, Hassan, Yang, Song
Published in Journal of medicinal chemistry (13.12.2018)
Published in Journal of medicinal chemistry (13.12.2018)
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Results and evaluation of a first‐in‐human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods
Sturm, Stefan, Delporte, Marie‐Laure, Hadi, Salah, Schobel, Scott, Lindemann, Lothar, Weikert, Robert, Jaeschke, Georg, Derks, Michael, Palermo, Giuseppe
Published in British journal of clinical pharmacology (01.03.2018)
Published in British journal of clinical pharmacology (01.03.2018)
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Novel benzothiophene-, benzofuran-, and naphthalenecarboxamidotetrazoles as potential antiallergy agents
Connor, David T, Cetenko, Wiaczeslaw A, Mullican, Michael D, Sorenson, Roderick J, Unangst, Paul C, Weikert, Robert J, Adolphson, Richard L, Kennedy, John A, Thueson, David O
Published in Journal of medicinal chemistry (01.03.1992)
Published in Journal of medicinal chemistry (01.03.1992)
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Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema
Sahni, Jayashree, Patel, Sunil S., Dugel, Pravin U., Khanani, Arshad M., Jhaveri, Chirag D., Wykoff, Charles C., Hershberger, Vrinda S., Pauly-Evers, Meike, Sadikhov, Shamil, Szczesny, Piotr, Schwab, Dietmar, Nogoceke, Everson, Osborne, Aaron, Weikert, Robert, Fauser, Sascha
Published in Ophthalmology (Rochester, Minn.) (01.08.2019)
Published in Ophthalmology (Rochester, Minn.) (01.08.2019)
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Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid
Nelson, Peter H, Carr, Stephen F, Devens, Bruce H, Eugui, Elsie M, Franco, Fidencio, Gonzalez, Carlos, Hawley, Ronald C, Loughhead, David G, Milan, David J, Papp, Eva, Patterson, John W, Rouhafza, Sussan, Sjogren, Eric B, Smith, David B, Stephenson, Rebecca A, Talamas, Francisco X, Waltos, Ann-Marie, Weikert, Robert J, Wu, John C
Published in Journal of medicinal chemistry (11.10.1996)
Published in Journal of medicinal chemistry (11.10.1996)
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Asymmetric Synthesis and Stereochemical Assignment of RS-97613, a Potent Immunosuppressive and Antiinflammatory Agent
Smith, David B, Waltos, Ann Marie, Loughhead, David G, Weikert, Robert J, Morgans, David J, Rohloff, John C, Link, John O, Zhu, Rong-rong
Published in Journal of organic chemistry (22.03.1996)
Published in Journal of organic chemistry (22.03.1996)
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안과 질환의 맞춤 치료
WEIKERT ROBERT JAMES, SILVERMAN DAVID ANDREW, WILLIS JEFFREY R, LIN HUGH, OSBORNE AARON
Year of Publication 11.03.2022
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Year of Publication 11.03.2022
Patent
Novel indolecarboxamidotetrazoles as potential antiallergy agents
Unangst, Paul C, Connor, David T, Stabler, S. Russell, Weikert, Robert J, Carethers, Mary E, Kennedy, John A, Thueson, David O, Chestnut, James C, Adolphson, Richard L, Conroy, M. C
Published in Journal of medicinal chemistry (01.06.1989)
Published in Journal of medicinal chemistry (01.06.1989)
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