Machine learning methods accurately predict host specificity of coronaviruses based on spike sequences alone
Kuzmin, Kiril, Adeniyi, Ayotomiwa Ezekiel, DaSouza, Arthur Kevin, Lim, Deuk, Nguyen, Huyen, Molina, Nuria Ramirez, Xiong, Lanqiao, Weber, Irene T., Harrison, Robert W.
Published in Biochemical and biophysical research communications (10.12.2020)
Published in Biochemical and biophysical research communications (10.12.2020)
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Evolution of drug resistance in HIV protease
Shah, Dhara, Freas, Christopher, Weber, Irene T, Harrison, Robert W
Published in BMC bioinformatics (30.12.2020)
Published in BMC bioinformatics (30.12.2020)
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Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PRS17
Agniswamy, Johnson, Kneller, Daniel W., Ghosh, Arun K., Weber, Irene T.
Published in Biochemical and biophysical research communications (20.08.2021)
Published in Biochemical and biophysical research communications (20.08.2021)
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Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site
Gerlits, Oksana, Wymore, Troy, Das, Amit, Shen, Chen-Hsiang, Parks, Jerry M., Smith, Jeremy C., Weiss, Kevin L., Keen, David A., Blakeley, Matthew P., Louis, John M., Langan, Paul, Weber, Irene T., Kovalevsky, Andrey
Published in Angewandte Chemie (International ed.) (11.04.2016)
Published in Angewandte Chemie (International ed.) (11.04.2016)
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Structure-Based Design of Highly Potent HIV‑1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X‑ray Structural Studies
Ghosh, Arun K, Kovela, Satish, Osswald, Heather L, Amano, Masayuki, Aoki, Manabu, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (14.05.2020)
Published in Journal of medicinal chemistry (14.05.2020)
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Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies
Ghosh, Arun K., Shahabi, Dana, Kipfmiller, Maya, Ghosh, Ajay K., Johnson, Megan, Wang, Yuan-Fang, Agniswamy, Johnson, Amano, Masayuki, Weber, Irene T., Mitsuya, Hiroaki
Published in Bioorganic & medicinal chemistry letters (01.03.2023)
Published in Bioorganic & medicinal chemistry letters (01.03.2023)
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Analysis of drug resistance in HIV protease
Pawar, Shrikant D, Freas, Christopher, Weber, Irene T, Harrison, Robert W
Published in BMC bioinformatics (22.10.2018)
Published in BMC bioinformatics (22.10.2018)
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Design and Development of Highly Potent HIV‑1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
Ghosh, Arun K, Rao, Kalapala Venkateswara, Nyalapatla, Prasanth R, Osswald, Heather L, Martyr, Cuthbert D, Aoki, Manabu, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Bulut, Haydar, Das, Debananda, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Highly resistant HIV-1 proteases and strategies for their inhibition
Weber, Irene T, Kneller, Daniel W, Wong-Sam, Andres
Published in Future medicinal chemistry (01.06.2015)
Published in Future medicinal chemistry (01.06.2015)
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Design and Synthesis of Potent HIV‑1 Protease Inhibitors Containing Bicyclic Oxazolidinone Scaffold as the P2 Ligands: Structure–Activity Studies and Biological and X‑ray Structural Studies
Ghosh, Arun K, Williams, Jacqueline N, Ho, Rachel Y, Simpson, Hannah M, Hattori, Shin-ichiro, Hayashi, Hironori, Agniswamy, Johnson, Wang, Yuan-Fang, Weber, Irene T, Mitsuya, Hiroaki
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Journal Article
Automated prediction of HIV drug resistance from genotype data
Shen, ChenHsiang, Yu, Xiaxia, Harrison, Robert W, Weber, Irene T
Published in BMC bioinformatics (31.08.2016)
Published in BMC bioinformatics (31.08.2016)
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HIV-1 Protease: Structural Perspectives on Drug Resistance
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