Inhibition of Soluble Epoxide Hydrolase Attenuated Atherosclerosis, Abdominal Aortic Aneurysm Formation, and Dyslipidemia
Zhang, Le-Ning, Vincelette, Jon, Cheng, Ying, Mehra, Upasana, Chen, Dawn, Anandan, Sampath-Kumar, Gless, Richard, Webb, Heather K, Wang, Yi-Xin (Jim)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.09.2009)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.09.2009)
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Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension
Zhang, Le-Ning, Vincelette, Jon, Chen, Dawn, Gless, Richard D., Anandan, Sampath-Kumar, Rubanyi, Gabor M., Webb, Heather K., MacIntyre, D. Euan, Wang, Yi-Xin (Jim)
Published in European journal of pharmacology (01.03.2011)
Published in European journal of pharmacology (01.03.2011)
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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
Ueda, Akiko, Hamadeh, Hisham K, Webb, Heather K, Yamamoto, Yukio, Sueyoshi, Tatsuya, Afshari, Cynthia A, Lehmann, Jürgen M, Negishi, Masahiko
Published in Molecular pharmacology (01.01.2002)
Published in Molecular pharmacology (01.01.2002)
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Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia
Brown, Jennifer R., Byrd, John C., Coutre, Steven E., Benson, Don M., Flinn, Ian W., Wagner-Johnston, Nina D., Spurgeon, Stephen E., Kahl, Brad S., Bello, Celeste, Webb, Heather K., Johnson, Dave M., Peterman, Sissy, Li, Daniel, Jahn, Thomas M., Lannutti, Brian J., Ulrich, Roger G., Yu, Albert S., Miller, Langdon L., Furman, Richard R.
Published in Blood (29.05.2014)
Published in Blood (29.05.2014)
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Idelalisib, a selective inhibitor of phosphatidylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma
Flinn, Ian W., Kahl, Brad S., Leonard, John P., Furman, Richard R., Brown, Jennifer R., Byrd, John C., Wagner-Johnston, Nina D., Coutre, Steve E., Benson, Don M., Peterman, Sissy, Cho, Yoonjin, Webb, Heather K., Johnson, David M., Yu, Albert S., Ulrich, Roger G., Godfrey, Wayne R., Miller, Langdon L., Spurgeon, Stephen E.
Published in Blood (29.05.2014)
Published in Blood (29.05.2014)
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Attenuation of cisplatin-induced renal injury by inhibition of soluble epoxide hydrolase involves nuclear factor κB signaling
Liu, Yingmei, Webb, Heather K, Fukushima, Hisayo, Micheli, Janine, Markova, Svetlana, Olson, Jean L, Kroetz, Deanna L
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2012)
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Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway
Liu, Yingmei, Lu, Xiaodan, Nguyen, Sinh, Olson, Jean L, Webb, Heather K, Kroetz, Deanna L
Published in Molecular pharmacology (01.12.2013)
Published in Molecular pharmacology (01.12.2013)
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Pharmacokinetics and pharmacodynamics of AR9281, an inhibitor of soluble epoxide hydrolase, in single- and multiple-dose studies in healthy human subjects
Chen, Dawn, Whitcomb, Randall, MacIntyre, Euan, Tran, Vinh, Do, Zung N, Sabry, James, Patel, Dinesh V, Anandan, Sampath K, Gless, Richard, Webb, Heather K
Published in Journal of clinical pharmacology (01.03.2012)
Published in Journal of clinical pharmacology (01.03.2012)
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Inhibiting TGF-beta signaling restores immune surveillance in the SMA-560 glioma model
Tran, Thomas-Toan, Uhl, Martin, Ma, Jing Ying, Janssen, Lisa, Sriram, Venkataraman, Aulwurm, Steffen, Kerr, Irene, Lam, Andrew, Webb, Heather K, Kapoun, Ann M, Kizer, Darin E, McEnroe, Glenn, Hart, Barry, Axon, Jonathan, Murphy, Alison, Chakravarty, Sarvajit, Dugar, Sundeep, Protter, Andrew A, Higgins, Linda S, Wick, Wolfgang, Weller, Michael, Wong, Darren H
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2007)
Published in Neuro-oncology (Charlottesville, Va.) (01.07.2007)
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Amino Acid/Spermine Conjugates: Polyamine Amides as Potent Spermidine Uptake Inhibitors
Burns, Mark R, Carlson, C. Lance, Vanderwerf, Scott M, Ziemer, Josh R, Weeks, Reitha S, Cai, Feng, Webb, Heather K, Graminski, Gerard F
Published in Journal of medicinal chemistry (25.10.2001)
Published in Journal of medicinal chemistry (25.10.2001)
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Pharmacological Properties of SD-282 – An α-Isoform Selective Inhibitor for p38 MAP Kinase
Koppelman, Bruce, Webb, Heather K., Medicherla, Satyanarayana, Almirez, Ramona, Feng, Ying, Chavez, Jose Carlos, Mao, Cheng Ping, Nguyen, Aaron, Liu, Yu-Wang, Kapoun, Ann M., Muiru, Gladys, Huang, Yuanying Anne, Dugar, Sundeep, Mavunkel, Babu J., Lim, Don W., Chakravarty, Sarvajit, Luedtke, Gregory, Protter, Andrew A., Higgins, Linda S.
Published in Pharmacology (01.01.2008)
Published in Pharmacology (01.01.2008)
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1-(N-Alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: Simple Synthetic Polyamine Analogues That Differentially Alter Tubulin Polymerization
Webb, Heather K, Wu, Zhiqian, Sirisoma, Nilantha, Ha, Hyo Chol, Casero, Robert A, Woster, Patrick M
Published in Journal of medicinal chemistry (22.04.1999)
Published in Journal of medicinal chemistry (22.04.1999)
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Clinical Pharmacokinetics of CAL-101, a p110δ Isoform-Selective PI3K Inhibitor, Following Single- and Multiple-Dose Administration In Healthy Volunteers and Patients with Hematological Malignancies
Webb, Heather K, Chen, Hao, Yu, Albert S, Peterman, Sissy, Holes, Leanne, Lannutti, Brian, Miller, Langdon L., Ulrich, Roger G
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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Abstract B136: CAL-120, a novel dual p110β/p110δ phosphatidylinositol-3-kinase (PI3K) inhibitor, attenuates PI3K signaling and demonstrates potent in vivo antitumor activity against solid tumors
Lannutti, Brian, Kashishian, Adam, Meadows, Sarah A., Steiner, Bart, Ueno, Lynn, Webb, Heather K., Puri, Kamal D., Ulrich, Roger G., Vogt, Peter K., Giese, Neill A.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Clinical Safety and Activity In a Phase 1 Study of CAL-101, An Isoform-Selective Inhibitor of Phosphatidylinositol 3-Kinase P110δ, In Patients with Relapsed or Refractory Non-Hodgkin Lymphoma
Kahl, Brad, Byrd, John C., Flinn, Ian W., Wagner-Johnston, Nina, Spurgeon, Stephen, Benson, Don M, Furman, Richard R., Brown, Jennifer R, Coutre, Steven, Lannutti, Brian, Giese, Neil A., Ulrich, Roger G, Webb, Heather K, Peterman, Sissy, Holes, Leanne, Yu, Albert S
Published in Blood (19.11.2010)
Published in Blood (19.11.2010)
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