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Lebeau, Paul F., Byun, Jae Hyun, Platko, Khrystyna, Saliba, Paul, Sguazzin, Matthew, MacDonald, Melissa E., Paré, Guillaume, Steinberg, Gregory R., Janssen, Luke J., Igdoura, Suleiman A., Tarnopolsky, Mark A., Wayne Chen, S. R., Seidah, Nabil G., Magolan, Jakob, Austin, Richard C.
Published in Nature communications (09.02.2022)
Published in Nature communications (09.02.2022)
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The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias
Chen, Wenqian, Wang, Ruiwu, Chen, Biyi, Zhong, Xiaowei, Kong, Huihui, Bai, Yunlong, Zhou, Qiang, Xie, Cuihong, Zhang, Jingqun, Guo, Ang, Tian, Xixi, Jones, Peter P, O'Mara, Megan L, Liu, Yingjie, Mi, Tao, Zhang, Lin, Bolstad, Jeff, Semeniuk, Lisa, Cheng, Hongqiang, Zhang, Jianlin, Chen, Ju, Tieleman, D Peter, Gillis, Anne M, Duff, Henry J, Fill, Michael, Song, Long-Sheng, Chen, S R Wayne
Published in Nature medicine (01.02.2014)
Published in Nature medicine (01.02.2014)
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Axoplasmic reticulum Ca2+ release causes secondary degeneration of spinal axons
Stirling, David P., Cummins, Karen, Wayne Chen, S. R., Stys, Peter
Published in Annals of neurology (01.02.2014)
Published in Annals of neurology (01.02.2014)
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Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation
Tambeaux, Allison, Aguilar-Sánchez, Yuriana, Santiago, Demetrio J., Mascitti, Madeleine, DiNovo, Karyn M., Mejía-Alvarez, Rafael, Fill, Michael, Wayne Chen, S. R., Ramos-Franco, Josefina
Published in Pflügers Archiv (01.05.2023)
Published in Pflügers Archiv (01.05.2023)
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Enhanced Store Overload–Induced Ca2+ Release and Channel Sensitivity to Luminal Ca2+ Activation Are Common Defects of RyR2 Mutations Linked to Ventricular Tachycardia and Sudden Death
Jiang, Dawei, Wang, Ruiwu, Xiao, Bailong, Kong, Huihui, Hunt, Donald J, Choi, Philip, Zhang, Lin, Chen, S R. Wayne
Published in Circulation research (25.11.2005)
Published in Circulation research (25.11.2005)
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Novel RyR2 Mutation (G3118R) Is Associated With Autosomal Recessive Ventricular Fibrillation and Sudden Death: Clinical, Functional, and Computational Analysis
Shauer, Ayelet, Shor, Oded, Wei, Jinhong, Elitzur, Yair, Kucherenko, Nataly, Wang, Ruiwu, Chen, S R Wayne, Einav, Yulia, Luria, David
Published in Journal of the American Heart Association (16.03.2021)
Published in Journal of the American Heart Association (16.03.2021)
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Generation and characterization of a mouse model harboring the exon-3 deletion in the cardiac ryanodine receptor
Liu, Yingjie, Wang, Ruiwu, Sun, Bo, Mi, Tao, Zhang, Jingqun, Mu, Yongxin, Chen, Ju, Bround, Michael J, Johnson, James D, Gillis, Anne M, Chen, S R Wayne
Published in PloS one (01.04.2014)
Published in PloS one (01.04.2014)
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Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2
Peng, Wei, Shen, Huaizong, Wu, Jianping, Guo, Wenting, Pan, Xiaojing, Wang, Ruiwu, Chen, S. R. Wayne, Yan, Nieng
Published in Science (American Association for the Advancement of Science) (21.10.2016)
Published in Science (American Association for the Advancement of Science) (21.10.2016)
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Modulation of cardiac ryanodine receptor 2 by calmodulin
Gong, Deshun, Chi, Ximin, Wei, Jinhong, Zhou, Gewei, Huang, Gaoxingyu, Zhang, Lin, Wang, Ruiwu, Lei, Jianlin, Chen, S. R. Wayne, Yan, Nieng
Published in Nature (London) (01.08.2019)
Published in Nature (London) (01.08.2019)
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Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory
Hiess, Florian, Yao, Jinjing, Song, Zhenpeng, Sun, Bo, Zhang, Zizhen, Huang, Junting, Chen, Lina, Institoris, Adam, Estillore, John Paul, Wang, Ruiwu, ter Keurs, Henk E. D. J., Stys, Peter K., Gordon, Grant R., Zamponi, Gerald W., Ganguly, Anutosh, Chen, S. R. Wayne
Published in Communications biology (01.03.2022)
Published in Communications biology (01.03.2022)
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Non-β-Blocking Carvedilol Analog, VK-II-86, Prevents Ouabain-Induced Cardiotoxicity
Gonano, Luis A., Sepúlveda, Marisa, Morell, Malena, Toteff, Tamara, Racioppi, María Florencia, Lascano, Elena, Negroni, Jorge, Ruocco, María Julieta Fernández, Medei, Emiliano, Neiman, Gabriel, Miriuka, Santiago G., Back, Thomas G., Chen, S. R. Wayne, Mattiazzi, Alicia, Petroff, Martin Vila
Published in Circulation Journal (25.12.2018)
Published in Circulation Journal (25.12.2018)
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Reduced expression of cardiac ryanodine receptor protects against stress-induced ventricular tachyarrhythmia, but increases the susceptibility to cardiac alternans
Zhong, Xiaowei, Vallmitjana, Alexander, Sun, Bo, Xiao, Zhichao, Guo, Wenting, Wei, Jinhong, Ni, Mingke, Chen, Yongxiang, O'Brien, Edward R, Gillis, Anne M, Hoshijima, Masahiko, Takeshima, Hiroshi, Hove-Madsen, Leif, Benitez, Raul, Belke, Darrell, Wayne Chen, S R
Published in Biochemical journal (15.01.2018)
Published in Biochemical journal (15.01.2018)
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Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias
Xiao, Jianmin, Tian, Xixi, Jones, Peter P., Bolstad, Jeff, Kong, Huihui, Wang, Ruiwu, Zhang, Lin, Duff, Henry J., Gillis, Anne M., Fleischer, Sidney, Kotlikoff, Michael, Copello, Julio A., Chen, S. R. Wayne
Published in The Journal of biological chemistry (30.11.2007)
Published in The Journal of biological chemistry (30.11.2007)
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K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association
Hunt, Donald J, Jones, Peter P, Wang, Ruiwu, Chen, Wenqian, Bolstad, Jeff, Chen, Keyun, Shimoni, Yakhin, Chen, S R Wayne
Published in Biochemical journal (15.06.2007)
Published in Biochemical journal (15.06.2007)
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RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation
Guo, Wenting, Wei, Jinhong, Estillore, John Paul, Zhang, Lin, Wang, Ruiwu, Sun, Bo, Chen, S. R. Wayne
Published in The Journal of biological chemistry (01.07.2021)
Published in The Journal of biological chemistry (01.07.2021)
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Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity
Eisner, Verónica, Cupo, Ryan R., Gao, Erhe, Csordás, György, Slovinsky, William S., Paillard, Melanie, Cheng, Lan, Ibetti, Jessica, Chen, S. R. Wayne, Chuprun, J. Kurt, Hoek, Jan B., Koch, Walter J., Hajnóczky, György
Published in Proceedings of the National Academy of Sciences - PNAS (31.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (31.01.2017)
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