Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression
Nighot, Meghali, Al-Sadi, Rana, Guo, Shuhong, Rawat, Manmeet, Nighot, Prashant, Watterson, Martin D., Ma, Thomas Y.
Published in The American journal of pathology (01.12.2017)
Published in The American journal of pathology (01.12.2017)
Get full text
Journal Article
Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis
Nighot, Prashant, Al-Sadi, Rana, Rawat, Manmeet, Guo, Shuhong, Watterson, D Martin, Ma, Thomas
Published in American journal of physiology: Gastrointestinal and liver physiology (15.12.2015)
Published in American journal of physiology: Gastrointestinal and liver physiology (15.12.2015)
Get full text
Journal Article
The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction
Acquarone, Erica, Argyrousi, Elentina K, Arancio, Ottavio, Watterson, D Martin, Roy, Saktimayee M
Published in Journal of Alzheimer's disease (01.01.2024)
Published in Journal of Alzheimer's disease (01.01.2024)
Get more information
Journal Article
Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment
Webster, Scott J, Van Eldik, Linda J, Watterson, D Martin, Bachstetter, Adam D
Published in The Journal of neuroscience (22.04.2015)
Published in The Journal of neuroscience (22.04.2015)
Get full text
Journal Article
PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation
Schmid, Michael C, Kang, Sang Won, Chen, Hui, Paradise, Marc, Ghebremedhin, Anghesom, Kaneda, Megan M, Chin, Shao-Ming, Do, Anh, Watterson, D Martin, Varner, Judith A
Published in Nature communications (01.04.2022)
Published in Nature communications (01.04.2022)
Get full text
Journal Article
Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
Braun, David J, Powell, David K, McLouth, Christopher J, Roy, Saktimayee M, Watterson, D Martin, Van Eldik, Linda J
Published in PloS one (26.01.2022)
Published in PloS one (26.01.2022)
Get full text
Journal Article
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
Bachstetter, Adam D, Xing, Bin, de Almeida, Lucia, Dimayuga, Edgardo R, Watterson, D Martin, Van Eldik, Linda J
Published in Journal of neuroinflammation (06.07.2011)
Published in Journal of neuroinflammation (06.07.2011)
Get full text
Journal Article
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy
Simon, Christian M., Van Alstyne, Meaghan, Lotti, Francesco, Bianchetti, Elena, Tisdale, Sarah, Watterson, D. Martin, Mentis, George Z., Pellizzoni, Livio
Published in Cell reports (Cambridge) (17.12.2019)
Published in Cell reports (Cambridge) (17.12.2019)
Get full text
Journal Article
Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
Maphis, Nicole, Jiang, Shanya, Xu, Guixiang, Kokiko-Cochran, Olga N, Roy, Saktimayee M, Van Eldik, Linda J, Watterson, D Martin, Lamb, Bruce T, Bhaskar, Kiran
Published in Alzheimer's research & therapy (15.12.2016)
Published in Alzheimer's research & therapy (15.12.2016)
Get full text
Journal Article
Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase
Morfini, Gerardo A, Bosco, Daryl A, Brown, Hannah, Gatto, Rodolfo, Kaminska, Agnieszka, Song, Yuyu, Molla, Linda, Baker, Lisa, Marangoni, M Natalia, Berth, Sarah, Tavassoli, Ehsan, Bagnato, Carolina, Tiwari, Ashutosh, Hayward, Lawrence J, Pigino, Gustavo F, Watterson, D Martin, Huang, Chun-Fang, Banker, Gary, Brown, Jr, Robert H, Brady, Scott T
Published in PloS one (12.06.2013)
Published in PloS one (12.06.2013)
Get full text
Journal Article
Glia Proinflammatory Cytokine Upregulation as a Therapeutic Target for Neurodegenerative Diseases: Function‐Based and Target‐Based Discovery Approaches
Van Eldik, Linda J., Thompson, Wendy L., Ranaivo, Hantamalala Ralay, Behanna, Heather A., Martin Watterson, D.
Published in International Review of Neurobiology (01.01.2007)
Published in International Review of Neurobiology (01.01.2007)
Get full text
Book Chapter
Journal Article
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury
Lloyd, Eric, Somera-Molina, Kathleen, Van Eldik, Linda J, Watterson, D Martin, Wainwright, Mark S
Published in Journal of neuroinflammation (30.06.2008)
Published in Journal of neuroinflammation (30.06.2008)
Get full text
Journal Article
Generation and behavior characterization of CaMKIIβ knockout mice
Bachstetter, Adam D, Webster, Scott J, Tu, Tao, Goulding, Danielle S, Haiech, Jacques, Watterson, D Martin, Van Eldik, Linda J
Published in PloS one (15.08.2014)
Published in PloS one (15.08.2014)
Get full text
Journal Article
Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
Watterson, D Martin, Grum-Tokars, Valerie L, Roy, Saktimayee M, Schavocky, James P, Bradaric, Brinda Desai, Bachstetter, Adam D, Xing, Bin, Dimayuga, Edgardo, Saeed, Faisal, Zhang, Hong, Staniszewski, Agnieszka, Pelletier, Jeffrey C, Minasov, George, Anderson, Wayne F, Arancio, Ottavio, Van Eldik, Linda J
Published in PloS one (26.06.2013)
Published in PloS one (26.06.2013)
Get full text
Journal Article
Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
Zhou, Zhengqiu, Bachstetter, Adam D, Späni, Claudia B, Roy, Saktimayee M, Watterson, D Martin, Van Eldik, Linda J
Published in Journal of neuroinflammation (05.04.2017)
Published in Journal of neuroinflammation (05.04.2017)
Get full text
Journal Article
Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures
Chrzaszcz, MaryAnn, Venkatesan, Charu, Dragisic, Tina, Watterson, D Martin, Wainwright, Mark S
Published in Journal of neurotrauma (01.07.2010)
Published in Journal of neurotrauma (01.07.2010)
Get full text
Journal Article
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
Munoz, Lenka, Ralay Ranaivo, Hantamalala, Roy, Saktimayee M, Hu, Wenhui, Craft, Jeffrey M, McNamara, Laurie K, Chico, Laura Wing, Van Eldik, Linda J, Watterson, D Martin
Published in Journal of neuroinflammation (04.09.2007)
Published in Journal of neuroinflammation (04.09.2007)
Get full text
Journal Article
Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model
Somera-Molina, Kathleen C, Nair, Sangeetha, Van Eldik, Linda J, Watterson, D. Martin, Wainwright, Mark S
Published in Brain research (28.07.2009)
Published in Brain research (28.07.2009)
Get full text
Journal Article
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses
Bachstetter, Adam D, Zhou, Zhengqiu, Rowe, Rachel K, Xing, Bin, Goulding, Danielle S, Conley, Alyssa N, Sompol, Pradoldej, Meier, Shelby, Abisambra, Jose F, Lifshitz, Jonathan, Watterson, D Martin, Van Eldik, Linda J
Published in PloS one (12.02.2016)
Published in PloS one (12.02.2016)
Get full text
Journal Article
Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury
Mirzapoiazova, Tamara, Moitra, Jaideep, Moreno-Vinasco, Liliana, Sammani, Saad, Turner, Jerry R, Chiang, Eddie T, Evenoski, Carrie, Wang, Ting, Singleton, Patrick A, Huang, Yong, Lussier, Yves A, Watterson, D Martin, Dudek, Steven M, Garcia, Joe G N
Published in American journal of respiratory cell and molecular biology (01.01.2011)
Published in American journal of respiratory cell and molecular biology (01.01.2011)
Get full text
Journal Article