Incidence and Etiology of Drug-Induced Liver Injury in Mainland China
Shen, Tao, Liu, Yingxia, Shang, Jia, Xie, Qing, Li, Jun, Yan, Ming, Xu, Jianming, Niu, Junqi, Liu, Jiajun, Watkins, Paul B., Aithal, Guruprasad P., Andrade, Raúl J., Dou, Xiaoguang, Yao, Lvfeng, Lv, Fangfang, Wang, Qi, Li, Yongguo, Zhou, Xinmin, Zhang, Yuexin, Zong, Peilan, Wan, Bin, Zou, Zhengsheng, Yang, Dongliang, Nie, Yuqiang, Li, Dongliang, Wang, Yuya, Han, Xi’an, Zhuang, Hui, Mao, Yimin, Chen, Chengwei
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2019)
Published in Gastroenterology (New York, N.Y. 1943) (01.06.2019)
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Hepatic histological findings in suspected drug‐induced liver injury: Systematic evaluation and clinical associations
Kleiner, David E., Chalasani, Naga P., Lee, William M., Fontana, Robert J., Bonkovsky, Herbert L., Watkins, Paul B., Hayashi, Paul H., Davern, Timothy J., Navarro, Victor, Reddy, Rajender, Talwalkar, Jayant A., Stolz, Andrew, Gu, Jiezhun, Barnhart, Huiman, Hoofnagle, Jay H.
Published in Hepatology (Baltimore, Md.) (01.02.2014)
Published in Hepatology (Baltimore, Md.) (01.02.2014)
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Polygenic architecture informs potential vulnerability to drug-induced liver injury
Koido, Masaru, Kawakami, Eri, Fukumura, Junko, Noguchi, Yui, Ohori, Momoko, Nio, Yasunori, Nicoletti, Paola, Aithal, Guruprasad P, Daly, Ann K, Watkins, Paul B, Anayama, Hisashi, Dragan, Yvonne, Shinozawa, Tadahiro, Takebe, Takanori
Published in Nature medicine (01.10.2020)
Published in Nature medicine (01.10.2020)
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Journal Article
Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort
Church, Rachel J., Kullak‐Ublick, Gerd A., Aubrecht, Jiri, Bonkovsky, Herbert L., Chalasani, Naga, Fontana, Robert J., Goepfert, Jens C., Hackman, Frances, King, Nicholas M. P., Kirby, Simon, Kirby, Patrick, Marcinak, John, Ormarsdottir, Sif, Schomaker, Shelli J., Schuppe‐Koistinen, Ina, Wolenski, Francis, Arber, Nadir, Merz, Michael, Sauer, John‐Michael, Andrade, Raul J., van Bömmel, Florian, Poynard, Thierry, Watkins, Paul B.
Published in Hepatology (Baltimore, Md.) (01.02.2019)
Published in Hepatology (Baltimore, Md.) (01.02.2019)
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In silico modeling to optimize interpretation of liver safety biomarkers in clinical trials
Church, Rachel J, Watkins, Paul B
Published in Experimental biology and medicine (Maywood, N.J.) (01.02.2018)
Published in Experimental biology and medicine (Maywood, N.J.) (01.02.2018)
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Journal Article
Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles
Lucena, M. Isabel, Molokhia, Mariam, Shen, Yufeng, Urban, Thomas J, Aithal, Guruprasad P, Andrade, Raúl J, Day, Christopher P, Ruiz–Cabello, Francisco, Donaldson, Peter T, Stephens, Camilla, Pirmohamed, Munir, Romero–Gomez, Manuel, Navarro, Jose Maria, Fontana, Robert J, Miller, Michael, Groome, Max, Bondon–Guitton, Emmanuelle, Conforti, Anita, Stricker, Bruno H.C, Carvajal, Alfonso, Ibanez, Luisa, Yue, Qun–Ying, Eichelbaum, Michel, Floratos, Aris, Pe'er, Itsik, Daly, Mark J, Goldstein, David B, Dillon, John F, Nelson, Matthew R, Watkins, Paul B, Daly, Ann K
Published in Gastroenterology (New York, N.Y. 1943) (01.07.2011)
Published in Gastroenterology (New York, N.Y. 1943) (01.07.2011)
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Assessing liver effects of Cannabidiol and Valproate alone and in Combination using Quantitative Systems Toxicology
Lakhani, Vinal V, Generaux, Grant, Howell, Brett A, Longo, Diane M, Watkins, Paul B
Published in Clinical pharmacology and therapeutics (01.11.2023)
Published in Clinical pharmacology and therapeutics (01.11.2023)
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Journal Article
Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective
Kenna, J. Gerry, Taskar, Kunal S., Battista, Christina, Bourdet, David L., Brouwer, Kim L.R., Brouwer, Kenneth R., Dai, David, Funk, Christoph, Hafey, Michael J., Lai, Yurong, Maher, Jonathan, Pak, Y. Anne, Pedersen, Jenny M., Polli, Joseph W., Rodrigues, A. David, Watkins, Paul B., Yang, Kyunghee, Yucha, Robert W.
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Journal Article
Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors
Woodhead, Jeffrey L, Brock, William J, Roth, Sharin E, Shoaf, Susan E, Brouwer, Kim L R, Church, Rachel, Grammatopoulos, Tom N, Stiles, Linsey, Siler, Scott Q, Howell, Brett A, Mosedale, Merrie, Watkins, Paul B, Shoda, Lisl K M
Published in Toxicological sciences (01.01.2017)
Published in Toxicological sciences (01.01.2017)
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Journal Article
Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury
Holman, Natalie S, Church, Rachel J, Nautiyal, Manisha, Rose, Kelly A, Thacker, Sarah E, Otieno, Monicah A, Wolf, Kristina K, LeCluyse, Edward, Watkins, Paul B, Mosedale, Merrie
Published in Toxicological sciences (01.08.2019)
Published in Toxicological sciences (01.08.2019)
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Journal Article
Cytokine profiles in acute liver injury-Results from the US Drug-Induced Liver Injury Network (DILIN) and the Acute Liver Failure Study Group
Bonkovsky, Herbert L, Barnhart, Huiman X, Foureau, David M, Steuerwald, Nury, Lee, William M, Gu, Jiezhun, Fontana, Robert J, Hayashi, Paul J, Chalasani, Naga, Navarro, Victor M, Odin, Joseph, Stolz, Andrew, Watkins, Paul B, Serrano, Jose
Published in PloS one (25.10.2018)
Published in PloS one (25.10.2018)
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Journal Article
Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization
Fu, Dong, Cardona, Panli, Ho, Henry, Watkins, Paul B, Brouwer, Kim L R
Published in Toxicological sciences (01.10.2019)
Published in Toxicological sciences (01.10.2019)
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Journal Article
Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury
Yang, Kyunghee, Guo, Cen, Woodhead, Jeffrey L., St. Claire, Robert L., Watkins, Paul B., Siler, Scott Q., Howell, Brett A., Brouwer, Kim L.R.
Published in Journal of pharmaceutical sciences (01.02.2016)
Published in Journal of pharmaceutical sciences (01.02.2016)
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