Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)
Watanabe, Kengo, Morishita, Kazuhiro, Zhou, Xiangyu, Shiizaki, Shigeru, Uchiyama, Yasuo, Koike, Masato, Naguro, Isao, Ichijo, Hidenori
Published in Nature communications (01.03.2021)
Published in Nature communications (01.03.2021)
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Journal Article
Mitogen-activated protein kinases as key players in osmotic stress signaling
Zhou, Xiangyu, Naguro, Isao, Ichijo, Hidenori, Watanabe, Kengo
Published in Biochimica et biophysica acta (01.09.2016)
Published in Biochimica et biophysica acta (01.09.2016)
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Journal Article
The regulatory and signaling mechanisms of the ASK family
Nishida, Takuto, Hattori, Kazuki, Watanabe, Kengo
Published in Advances in biological regulation (01.12.2017)
Published in Advances in biological regulation (01.12.2017)
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Journal Article
The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
Katayama, Ryohei, Gong, Bo, Togashi, Noriko, Miyamoto, Masaya, Kiga, Masaki, Iwasaki, Shiho, Kamai, Yasuki, Tominaga, Yuichi, Takeda, Yasuyuki, Kagoshima, Yoshiko, Shimizu, Yuki, Seto, Yosuke, Oh-hara, Tomoko, Koike, Sumie, Nakao, Naoki, Hanzawa, Hiroyuki, Watanabe, Kengo, Yoda, Satoshi, Yanagitani, Noriko, Hata, Aaron N., Shaw, Alice T., Nishio, Makoto, Fujita, Naoya, Isoyama, Takeshi
Published in Nature communications (09.08.2019)
Published in Nature communications (09.08.2019)
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Journal Article
Cryo-EM structures of the human volume-regulated anion channel LRRC8
Kasuya, Go, Nakane, Takanori, Yokoyama, Takeshi, Jia, Yanyan, Inoue, Masato, Watanabe, Kengo, Nakamura, Ryoki, Nishizawa, Tomohiro, Kusakizako, Tsukasa, Tsutsumi, Akihisa, Yanagisawa, Haruaki, Dohmae, Naoshi, Hattori, Motoyuki, Ichijo, Hidenori, Yan, Zhiqiang, Kikkawa, Masahide, Shirouzu, Mikako, Ishitani, Ryuichiro, Nureki, Osamu
Published in Nature structural & molecular biology (01.09.2018)
Published in Nature structural & molecular biology (01.09.2018)
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Journal Article
A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress
Watanabe, Kengo, Umeda, Tsuyoshi, Niwa, Kuniyoshi, Naguro, Isao, Ichijo, Hidenori
Published in Cell reports (Cambridge) (13.03.2018)
Published in Cell reports (Cambridge) (13.03.2018)
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Journal Article
A Novel Lens for Cell Volume Regulation: Liquid-Liquid Phase Separation
Ishihara, Shunya, Ichijo, Hidenori, Watanabe, Kengo
Published in Cellular physiology and biochemistry (21.04.2021)
Published in Cellular physiology and biochemistry (21.04.2021)
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Journal Article
Recent Advances in the Gastrointestinal Complex in Vitro Model for ADME Studies
Michiba, Kazuyoshi, Watanabe, Kengo, Imaoka, Tomoki, Nakai, Daisuke
Published in Pharmaceutics (27.12.2023)
Published in Pharmaceutics (27.12.2023)
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Journal Article
Effect of substrate concentration on reactive metabolite assessment in drug discovery research
Ozawa, Makoto, Shiozawa, Hideyuki, Shimada, Masaya, Makino, Chie, Takakusa, Hideo, Watanabe, Kengo, Suzuki, Kyosuke
Published in Drug metabolism and pharmacokinetics (01.04.2024)
Published in Drug metabolism and pharmacokinetics (01.04.2024)
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Journal Article
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1
Sugawara, Sho, Kanamaru, Yusuke, Sekine, Shiori, Maekawa, Lila, Takahashi, Akinori, Yamamoto, Tadashi, Watanabe, Kengo, Fujisawa, Takao, Hattori, Kazuki, Ichijo, Hidenori
Published in The Journal of biological chemistry (24.04.2020)
Published in The Journal of biological chemistry (24.04.2020)
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Journal Article
Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models
Yamada, Makiko, Inoue, Shin-Ichi, Sugiyama, Daisuke, Nishiya, Yumi, Ishizuka, Tomoko, Watanabe, Akiko, Watanabe, Kengo, Yamashita, Shinji, Watanabe, Nobuaki
Published in Drug metabolism and disposition (01.04.2020)
Published in Drug metabolism and disposition (01.04.2020)
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Journal Article
ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes
Takayanagi, Saki, Watanabe, Kengo, Maruyama, Takeshi, Ogawa, Motoyuki, Morishita, Kazuhiro, Soga, Mayumi, Hatta, Tomohisa, Natsume, Tohru, Hirano, Tomoya, Kagechika, Hiroyuki, Hattori, Kazuki, Naguro, Isao, Ichijo, Hidenori
Published in Scientific reports (10.11.2021)
Published in Scientific reports (10.11.2021)
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Journal Article
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers
Amai, Keito, Fukami, Tatsuki, Ichida, Hiroyuki, Watanabe, Akiko, Nakano, Masataka, Watanabe, Kengo, Nakajima, Miki
Published in Drug metabolism and pharmacokinetics (01.12.2020)
Published in Drug metabolism and pharmacokinetics (01.12.2020)
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Journal Article
Advances in Interfacing Optical Fibers to Nanophotonic Waveguides Via Mechanically Compliant Polymer Waveguides
Barwicz, Tymon, Janta-Polczynski, Alexander, Takenobu, Shotaro, Watanabe, Kengo, Langlois, Richard, Taira, Yoichi, Suematsu, Katsuki, Numata, Hidetoshi, Peng, Bo, Kamlapurkar, Swetha, Engelmann, Sebastian, Fortier, Paul, Boyer, Nicolas
Published in IEEE journal of selected topics in quantum electronics (01.03.2020)
Published in IEEE journal of selected topics in quantum electronics (01.03.2020)
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Journal Article
Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Nakamura, Ryoki, Numata, Tomohiro, Kasuya, Go, Yokoyama, Takeshi, Nishizawa, Tomohiro, Kusakizako, Tsukasa, Kato, Takafumi, Hagino, Tatsuya, Dohmae, Naoshi, Inoue, Masato, Watanabe, Kengo, Ichijo, Hidenori, Kikkawa, Masahide, Shirouzu, Mikako, Jentsch, Thomas J., Ishitani, Ryuichiro, Okada, Yasunobu, Nureki, Osamu
Published in Communications biology (15.05.2020)
Published in Communications biology (15.05.2020)
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