Discovery of Disubstituted Cyclohexanes as a New Class of CC Chemokine Receptor 2 Antagonists
Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Nelson, David J, Lo, Yvonne C, Yang, Gengjie, Scherle, Peggy A, Mandlekar, Sandhya, Wasserman, Zelda R, Jezak, Heather, Solomon, Kimberly A, Tebben, Andrew J, Carter, Percy H, Decicco, Carl P
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
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Journal Article
Structural Basis for Inhibition of Protein-tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
Ala, Paul J., Gonneville, Lucie, Hillman, Milton C., Becker-Pasha, Mary, Wei, Min, Reid, Brian G., Klabe, Ronald, Yue, Eddy W., Wayland, Brian, Douty, Brent, Polam, Padmaja, Wasserman, Zelda, Bower, Michael, Combs, Andrew P., Burn, Timothy C., Hollis, Gregory F., Wynn, Richard
Published in The Journal of biological chemistry (27.10.2006)
Published in The Journal of biological chemistry (27.10.2006)
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Journal Article
Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships
Duan, James J.-W, Chen, Lihua, Wasserman, Zelda R, Lu, Zhonghui, Liu, Rui-Qin, Covington, Maryanne B, Qian, Mingxin, Hardman, Karl D, Magolda, Ronald L, Newton, Robert C, Christ, David D, Wexler, Ruth R, Decicco, Carl P
Published in Journal of medicinal chemistry (07.11.2002)
Published in Journal of medicinal chemistry (07.11.2002)
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Journal Article
Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors
Duan, James J.-W., Chen, Lihua, Lu, Zhonghui, Xue, Chu-Biao, Liu, Rui-Qin, Covington, Maryanne B., Qian, Mingxin, Wasserman, Zelda R., Vaddi, Krishna, Christ, David D., Trzaskos, James M., Newton, Robert C., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Identification of Peptide Substrates for Human MMP-11 (Stromelysin-3) Using Phage Display
Pan, Weijun, Arnone, Marc, Kendall, Marvin, Grafstrom, Robert H., Seitz, Steven P., Wasserman, Zelda R., Albright, Charles F.
Published in The Journal of biological chemistry (25.07.2003)
Published in The Journal of biological chemistry (25.07.2003)
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Journal Article
Discovery of a Potent, Selective, and Orally Active Human Epidermal Growth Factor Receptor-2 Sheddase Inhibitor for the Treatment of Cancer
Yao, Wenqing, Zhuo, Jincong, Burns, David M, Xu, Meizhong, Zhang, Colin, Li, Yun-Long, Qian, Ding-Quan, He, Chunhong, Weng, Lingkai, Shi, Eric, Lin, Qiyan, Agrios, Costas, Burn, Timothy C, Caulder, Eian, Covington, Maryanne B, Fridman, Jordan S, Friedman, Steven, Katiyar, Kamna, Hollis, Gregory, Li, Yanlong, Liu, Changnian, Liu, Xiangdong, Marando, Cindy A, Newton, Robert, Pan, Max, Scherle, Peggy, Taylor, Nancy, Vaddi, Kris, Wasserman, Zelda R, Wynn, Richard, Yeleswaram, Swamy, Jalluri, Ravi, Bower, Michael, Zhou, Bing-Bing, Metcalf, Brian
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Journal Article
Glycine α-Ketoamides as HCV NS3 Protease Inhibitors
Han, Wei, Hu, Zilun, Jiang, Xiangjun, Wasserman, Zelda R., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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Journal Article
Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors
Cherney, Robert J, Duan, James J.-W, Voss, Matthew E, Chen, Lihua, Wang, Li, Meyer, Dayton T, Wasserman, Zelda R, Hardman, Karl D, Liu, Rui-Qin, Covington, Maryanne B, Qian, Mingxin, Mandlekar, Sandhya, Christ, David D, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P
Published in Journal of medicinal chemistry (08.05.2003)
Published in Journal of medicinal chemistry (08.05.2003)
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Journal Article
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme
Duan, James J.-W., Lu, Zhonghui, Wasserman, Zelda R., Liu, Rui-Qin, Covington, Maryanne B., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
Published in Bioorganic & medicinal chemistry letters (15.06.2005)
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Journal Article
Protein Design, a Minimalist Approach
DeGrado, William F., Wasserman, Zelda R., Lear, James D.
Published in Science (American Association for the Advancement of Science) (03.02.1989)
Published in Science (American Association for the Advancement of Science) (03.02.1989)
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Journal Article
Corticotropin-Releasing Hormone Receptor Antagonists: Framework Design and Synthesis Guided by Ligand Conformational Studies
Hodge, C. Nicholas, Aldrich, Paul E, Wasserman, Zelda R, Fernandez, Christina H, Nemeth, Gregory A, Arvanitis, Argyrios, Cheeseman, Robert S, Chorvat, Robert J, Ciganek, Engelbert, Christos, Thomas E, Gilligan, Paul J, Krenitsky, Paul, Scholfield, Everett, Strucely, Philip
Published in Journal of medicinal chemistry (11.03.1999)
Published in Journal of medicinal chemistry (11.03.1999)
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Journal Article
Sultam Hydroxamates as Novel Matrix Metalloproteinase Inhibitors
Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Hardman, Karl D, Liu, Rui-Qin, Covington, Maryanne B, Qian, Mingxin, Wasserman, Zelda R, Christ, David D, Trzaskos, James M, Newton, Robert C, Decicco, Carl P
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Journal Article
Design and identification of selective HER-2 sheddase inhibitors via P1′ manipulation and unconventional P2′ perturbations to induce a molecular metamorphosis
Yao, Wenqing, Zhuo, Jincong, Burns, David M., Li, Yun-Long, Qian, Ding-Quan, Zhang, Colin, He, Chunhong, Xu, Meizhong, Shi, Eric, Li, Yanlong, Marando, Cindy A., Covington, Maryanne B., Yang, Gengjie, Liu, Xiangdong, Pan, Max, Fridman, Jordan S., Scherle, Peggy, Wasserman, Zelda R., Hollis, Gregory, Vaddi, Kris, Yeleswaram, Swamy, Newton, Robert, Friedman, Steve, Metcalf, Brian
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Synthetic peptides as models for ion channel proteins
Akerfeldt, Karin S, Lear, Jim D, Wasserman, Zelda R, Chung, Laura A, DeGrado, William F
Published in Accounts of chemical research (01.04.1993)
Published in Accounts of chemical research (01.04.1993)
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Journal Article
Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Duan, James J.-W., Lu, Zhonghui, Xue, Chu-Biao, He, Xiaohua, Seng, Jennifer L., Roderick, John J., Wasserman, Zelda R., Liu, Rui-Qin, Covington, Maryanne B., Magolda, Ronald L., Newton, Robert C., Trzaskos, James M., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
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Journal Article
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents
Cherney, Robert J, Mo, Ruowei, Meyer, Dayton T, Wang, Li, Yao, Wenqing, Wasserman, Zelda R, Liu, Rui-Qin, Covington, Maryanne B, Tortorella, Micky D, Arner, Elizabeth C, Qian, Mingxin, Christ, David D, Trzaskos, James M, Newton, Robert C, Magolda, Ron L, Decicco, Carl P
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
Published in Bioorganic & medicinal chemistry letters (07.04.2003)
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Journal Article
Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release
Xue, Chu-Biao, He, Xiaohua, Corbett, Ronald L, Roderick, John, Wasserman, Zelda R, Liu, Rui-Qin, Jaffee, Bruce D, Covington, Maryanne B, Qian, Mingxin, Trzaskos, James M, Newton, Robert C, Magolda, Ronald L, Wexler, Ruth R, Decicco, Carl P
Published in Journal of medicinal chemistry (11.10.2001)
Published in Journal of medicinal chemistry (11.10.2001)
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Journal Article
Potent P1′ biphenylmethyl substituted aggrecanase inhibitors
Yao, Wenqing, Chao, Michael, Wasserman, Zelda R., Liu, Rui-Qin, Covington, Maryanne B., Newton, Robert, Christ, David, Wexler, Ruth R., Decicco, Carl P.
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
Published in Bioorganic & medicinal chemistry letters (07.01.2002)
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