High-Throughput Virtual Screening Identifies Novel N′‑(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors
Sorna, Venkataswamy, Theisen, Emily R, Stephens, Bret, Warner, Steven L, Bearss, David J, Vankayalapati, Hariprasad, Sharma, Sunil
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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Journal Article
Targeting Axl and Mer kinases in cancer
Verma, Anupam, Warner, Steven L, Vankayalapati, Hariprasad, Bearss, David J, Sharma, Sunil
Published in Molecular cancer therapeutics (01.10.2011)
Published in Molecular cancer therapeutics (01.10.2011)
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An Epithelial―Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
AVERETT BYERS, Lauren, LIXIA DIAO, NILSSON, Monique B, GUDIKOTE, Jayanthi, TRAN, Hai, CARDNELL, Robert J. G, BEARSS, David J, WARNER, Steven L, FOULKS, Jason M, KANNER, Steven B, GANDHI, Varsha, KRETT, Nancy, JING WANG, ROSEN, Steven T, KIM, Edward S, HERBST, RoyS, BLUMENSCHEIN, George R, LEE, J. Jack, LIPPMAN, Scott M, KIAN ANG, K, MILLS, Gordon B, HONG, Waun K, WEINSTEIN, John N, SAINTIGNY, Pierre, WISTUBA, Ignacio I, COOMBES, Kevin R, MINNA, John D, HEYMACH, John V, GIRARD, Luc, PEYTON, Michael, LI SHEN, YOUHONG FAN, GIRI, Uma, TUMULA, Praveen K
Published in Clinical cancer research (01.01.2013)
Published in Clinical cancer research (01.01.2013)
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Journal Article
S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth
Chuang, Jody C, Warner, Steven L, Vollmer, David, Vankayalapati, Hariprasad, Redkar, Sanjeev, Bearss, David J, Qiu, Xiangning, Yoo, Christine B, Jones, Peter A
Published in Molecular cancer therapeutics (01.05.2010)
Published in Molecular cancer therapeutics (01.05.2010)
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Journal Article
TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth
Chan, Tsz-Yin, Egbert, Christina M., Maxson, Julia E., Siddiqui, Adam, Larsen, Logan J., Kohler, Kristina, Balasooriya, Eranga Roshan, Pennington, Katie L., Tsang, Tsz-Ming, Frey, Madison, Soderblom, Erik J., Geng, Huimin, Müschen, Markus, Forostyan, Tetyana V., Free, Savannah, Mercenne, Gaelle, Banks, Courtney J., Valdoz, Jonard, Whatcott, Clifford J., Foulks, Jason M., Bearss, David J., O’Hare, Thomas, Huang, David C. S., Christensen, Kenneth A., Moody, James, Warner, Steven L., Tyner, Jeffrey W., Andersen, Joshua L.
Published in Nature communications (09.09.2021)
Published in Nature communications (09.09.2021)
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TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase
XIAOPING WANG, SASO, Hitomi, HORTOBAGYI, Gabriel N, HUNG, Mien-Chie, UENO, Naoto T, IWAMOTO, Takayuki, WEIYA XIA, YUN GONG, PUSZTAI, Lajos, WOODWARD, Wendy A, REUBEN, James M, WARNER, Steven L, BEARSS, David J
Published in Cancer research (Chicago, Ill.) (01.11.2013)
Published in Cancer research (Chicago, Ill.) (01.11.2013)
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Journal Article
Validation of TPX2 as a Potential Therapeutic Target in Pancreatic Cancer Cells
Warner, Steven L, Stephens, Bret J, Nwokenkwo, Stanley, Hostetter, Galen, Sugeng, Anastasia, Hidalgo, Manuel, Trent, Jeffery M, Han, Haiyong, Von Hoff, Daniel D
Published in Clinical cancer research (01.11.2009)
Published in Clinical cancer research (01.11.2009)
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Journal Article
A Small-Molecule Inhibitor of PIM Kinases as a Potential Treatment for Urothelial Carcinomas
Foulks, Jason M, Carpenter, Kent J, Luo, Bai, Xu, Yong, Senina, Anna, Nix, Rebecca, Chan, Ashley, Clifford, Adrianne, Wilkes, Marcus, Vollmer, David, Brenning, Benjamin, Merx, Shannon, Lai, Shuping, McCullar, Michael V, Ho, Koc-Kan, Albertson, Daniel J, Call, Lee T, Bearss, Jared J, Tripp, Sheryl, Liu, Ting, Stephens, Bret J, Mollard, Alexis, Warner, Steven L, Bearss, David J, Kanner, Steven B
Published in Neoplasia (New York, N.Y.) (01.05.2014)
Published in Neoplasia (New York, N.Y.) (01.05.2014)
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Upregulation of AXL and β-catenin in chronic lymphocytic leukemia cells cultured with bone marrow stroma cells is associated with enhanced drug resistance
Sinha, Sutapa, Secreto, Charla R., Boysen, Justin C., Lesnick, Connie, Wang, Zhiquan, Ding, Wei, Call, Timothy G., Kenderian, Saad J., Parikh, Sameer A., Warner, Steven L., Bearss, David J., Ghosh, Asish K., Kay, Neil E.
Published in Blood cancer journal (New York) (18.02.2021)
Published in Blood cancer journal (New York) (18.02.2021)
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Journal Article
Identification of a lead small-molecule inhibitor of the Aurora kinases using a structure-assisted, fragment-based approach
Warner, Steven L, Bashyam, Sridevi, Vankayalapati, Hariprasad, Bearss, David J, Han, Haiyong, Mahadevan, Daruka, Von Hoff, Daniel D, Hurley, Laurence H
Published in Molecular cancer therapeutics (01.07.2006)
Published in Molecular cancer therapeutics (01.07.2006)
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Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells
Warner, Steven L, Munoz, Ruben M, Stafford, Phillip, Koller, Erich, Hurley, Laurence H, Von Hoff, Daniel D, Han, Haiyong
Published in Molecular cancer therapeutics (01.10.2006)
Published in Molecular cancer therapeutics (01.10.2006)
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Molecular glues: enhanced protein-protein interactions and cell proteome editing
Weagel, Evita G., Foulks, Jason M., Siddiqui, Adam, Warner, Steven L.
Published in Medicinal chemistry research (01.07.2022)
Published in Medicinal chemistry research (01.07.2022)
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Journal Article
Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors
Sinha, Sutapa, Boysen, Justin, Nelson, Michael, Secreto, Charla, Warner, Steven L, Bearss, David J, Lesnick, Connie, Shanafelt, Tait D, Kay, Neil E, Ghosh, Asish K
Published in Clinical cancer research (01.05.2015)
Published in Clinical cancer research (01.05.2015)
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Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models
Dutta, Avik, Nath, Dipmoy, Yang, Yue, Le, Bao T., Rahman, Mohammad Ferdous-Ur, Faughnan, Patrick, Wang, Zhenjia, Stuver, Matthew, He, Rongquan, Tan, Wuwei, Hutchison, Robert E., Foulks, Jason M., Warner, Steven L., Zang, Chongzhi, Mohi, Golam
Published in Leukemia (01.03.2022)
Published in Leukemia (01.03.2022)
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TP-0184 inhibits FLT3/ACVR1 to overcome FLT3 inhibitor resistance and hinder AML growth synergistically with venetoclax
Tyagi, Anudishi, Jaggupilli, Appalaraju, Ly, Stanley, Yuan, Bin, El-Dana, Fouad, Hegde, Venkatesh L., Anand, Vivek, Kumar, Bijender, Puppala, Mamta, Yin, Zheng, Wong, Stephen T. C., Mollard, Alexis, Vankayalapati, Hariprasad, Foulks, Jason M., Warner, Steven L., Daver, Naval, Borthakur, Gautam, Battula, V. Lokesh
Published in Leukemia (01.01.2024)
Published in Leukemia (01.01.2024)
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Journal Article
Tubulin-associated proteins: Aurora and Polo-like kinases as therapeutic targets in cancer
Warner, Steven L., Stephens, Bret J., Von Hoff, Daniel D.
Published in Current oncology reports (01.03.2008)
Published in Current oncology reports (01.03.2008)
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Fragment-based design, synthesis, biological evaluation, and SAR of 1H-benzo[d]imidazol-2-yl)-1H-indazol derivatives as potent PDK1 inhibitors
Chen, Ting, Sorna, Venkataswamy, Choi, Susie, Call, Lee, Bearss, Jared, Carpenter, Kent, Warner, Steven L., Sharma, Sunil, Bearss, David J., Vankayalapati, Hariprasad
Published in Bioorganic & medicinal chemistry letters (15.12.2017)
Published in Bioorganic & medicinal chemistry letters (15.12.2017)
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Journal Article
Activators of PKM2 in cancer metabolism
Warner, Steven L, Carpenter, Kent J, Bearss, David J
Published in Future medicinal chemistry (01.06.2014)
Published in Future medicinal chemistry (01.06.2014)
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