Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
Pinto, Donald J. P, Orwat, Michael J, Wang, Shuaige, Fevig, John M, Quan, Mimi L, Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A, Alexander, Richard S, Smallwood, Angela M, Luettgen, Joseph M, Liang, Li, Aungst, Bruce J, Wright, Matthew R, Knabb, Robert M, Wong, Pancras C, Wexler, Ruth R, Lam, Patrick Y. S
Published in Journal of medicinal chemistry (15.02.2001)
Published in Journal of medicinal chemistry (15.02.2001)
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SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
SMALLHEER, Joanne M, ALEXANDER, Richard S, KNABB, Robert M, WEXLER, Ruth R, JADHAV, Prabhakar K, JIANMIN WANG, SHUAIGE WANG, NAKAJIMA, Suanne, ROSSI, Karen A, SMALLWOOD, Angela, BARBERA, Frank, BURDICK, Debra, LUETTGEN, Joseph M
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Sulfonamidolactam inhibitors of coagulation factor Xa
Smallheer, Joanne M., Wang, Shuaige, Laws, Mia L., Nakajima, Suanne, Hu, Zilun, Han, Wei, Jacobson, Irina, Luettgen, Joseph M., Rossi, Karen A., Rendina, Alan R., Knabb, Robert M., Wexler, Ruth R., Lam, Patrick Y.S., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Identification and characterization of antibodies that bind GPIIb/IIIa: Antagonist complexes
Breth, Leah, Kochie, Jennifer, Combs, Amanda, Wang, Shuaige, Smallheer, Joanne, Billheimer, Jeffrey, Seiffert, Dietmar, Hollis, Gregory, O'Neil, Karyn
Published in Journal of immunological methods (01.06.2005)
Published in Journal of immunological methods (01.06.2005)
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Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists
Xue, Chu-Biao, Wityak, John, Sielecki, Thais M, Pinto, Donald J, Batt, Douglas G, Cain, Gary A, Sworin, Michael, Rockwell, Arlene L, Roderick, John J, Wang, Shuaige, Orwat, Michael J, Frietze, William E, Bostrom, Lori L, Liu, Jie, Higley, C. Anne, Rankin, F. Wayne, Tobin, A. Ewa, Emmett, George, Lalka, George K, Sze, Jean Y, Di Meo, Susan V, Mousa, Shaker A, Thoolen, Martin J, Racanelli, Adrienne L, Hausner, Elizabeth A, Reilly, Thomas M, DeGrado, William F, Wexler, Ruth R, Olson, Richard E
Published in Journal of medicinal chemistry (20.06.1997)
Published in Journal of medicinal chemistry (20.06.1997)
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Discovery of Potent Isoxazoline Glycoprotein IIb/IIIa Receptor Antagonists
Wityak, John, Sielecki, Thais M, Pinto, Donald J, Emmett, George, Sze, Jean Y, Liu, Jie, Tobin, A. Ewa, Wang, Shuaige, Jiang, Biao, Ma, Philip, Mousa, Shaker A, Wexler, Ruth R, Olson, Richard E
Published in Journal of medicinal chemistry (03.01.1997)
Published in Journal of medicinal chemistry (03.01.1997)
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Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core
Fevig, John M., Pinto, Donald J., Han, Qi, Quan, Mimi L., Pruitt, James R., Jacobson, Irina C., Galemmo, Jr, Robert A., Wang, Shuaige, Orwat, Michael J., Bostrom, Lori L., Knabb, Robert M., Wong, Pancras C., Lam, Patrick Y.S., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitors
Pinto, Donald J.P., Copeland, Robert A., Covington, Maryanne B., Pitts, William J., Batt, Douglas G., Orwat, Michael J., Lam, Gilbert N., Joshi, Amita, Chan, Yuk-Charn, Wang, Shuaige, Trzaskos, James M., Magolda, Ronald L., Kornhauser, David M.
Published in Bioorganic & medicinal chemistry letters (17.12.1996)
Published in Bioorganic & medicinal chemistry letters (17.12.1996)
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Terphenyl cyclooxygenase-2 (COX-2) inhibitors: Optimization of the central ring and o-biphenyl analogs
Pinto, Donald J.P., Batt, Douglas G., Pitts, William J., Petraitis, Joseph J., Orwat, Michael J., Wang, Shuaige, Jetter, James W., Sherk, Susan R., Houghton, Gregory C., Copeland, Robert A., Covington, Maryanne B., Trzaskos, James M., Magolda, Ronald L.
Published in Bioorganic & medicinal chemistry letters (05.04.1999)
Published in Bioorganic & medicinal chemistry letters (05.04.1999)
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Journal Article
Discovery of 1-[3-(Aminomethyl)phenyl]- N -[3-fluoro-2‘-(methylsulfonyl)- [1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)-1 H -pyrazole-5-carboxamide (DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa
Pinto, Donald J. P., Orwat, Michael J., Wang, Shuaige, Fevig, John M., Quan, Mimi L., Amparo, Eugene, Cacciola, Joseph, Rossi, Karen A., Alexander, Richard S., Smallwood, Angela M., Luettgen, Joseph M., Liang, Li, Aungst, Bruce J., Wright, Matthew R., Knabb, Robert M., Wong, Pancras C., Wexler, Ruth R., Lam, Patrick Y. S.
Published in Journal of medicinal chemistry (01.02.2001)
Published in Journal of medicinal chemistry (01.02.2001)
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Journal Article
The Discovery of Potent Isoxazoline Glycoprotein IIb/IIIa Receptor Antagonists
Wityak, John, Sielecki, Thais M, Pinto, Donald J, Emmett, George, Sze, Jean Y, Liu, Jie, Tobin, A. Ewa, Wang, Shuaige, Jiang, Biao, Ma, Philip, Mousa, Shaker A, Olson, Richard E, Wexler, Ruth R
Published in Journal of medicinal chemistry (11.04.1997)
Published in Journal of medicinal chemistry (11.04.1997)
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Journal Article
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
Smallheer, Joanne M, Pinto, Donald J, Wang, Shuaige, Qiao, Jennifer X, Han, Wei, Hu, Zilun
Year of Publication 28.04.2009
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Year of Publication 28.04.2009
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MONOZYKLISCHE ODER BIZYKLISCHE CARBOZYKLEN UND HETEROZYKLEN ALS HEMMER VON FACTOR XA
QUAN, MIMI, JACOBSON, IRINA, WANG, SHUAIGE, SMALLHEER, JOANNE, WEXLER, RUTH, QIAO, JENNIFER, NAKAJIMA, SUANNE
Year of Publication 15.09.2008
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Year of Publication 15.09.2008
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BIARYLMETHYL INDOLINES, INDOLES AND TETRAHYDROQUINOLINES, USEFUL AS SERINE PROTEASE INHIBITORS
BISACCHI, GREGORY, S, WANG, SHUAIGE, QUAN, MIMI, L, SMALLHEER, JOANNE, M
Year of Publication 26.03.2008
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Year of Publication 26.03.2008
Patent