Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
Defining stratigraphic oil and gas plays by modifying structural plays: A case study from the Xihu Sag, east China Sea Shelf Basin
Ding, Feng, Xie, Chunyu, Zhou, Xinghai, Jiang, Cen, Li, Kun, Wan, Lifeng, Zhang, Pei, Niu, Huawei
Published in Energy Geoscience (01.01.2021)
Published in Energy Geoscience (01.01.2021)
Get full text
Journal Article
A Review on Biomass Gasification: Effect of Main Parameters on Char Generation and Reaction
Zhang, Yuming, Wan, Lifeng, Guan, Juntao, Xiong, Qing’an, Zhang, Shu, Jin, Xin
Published in Energy & fuels (19.11.2020)
Published in Energy & fuels (19.11.2020)
Get full text
Journal Article
Base-acid relay catalytic upgrading of coal pyrolysis volatiles over CaO and HZSM-5 catalysts
Yang, Hang, Zhang, Jiehan, Chen, Zhaohui, Wan, Lifeng, Li, Changming, Zhang, Xinyu, Li, Jianling, Tian, Ruoxuan, Yu, Jian, Gao, Shiqiu
Published in Journal of analytical and applied pyrolysis (01.03.2023)
Published in Journal of analytical and applied pyrolysis (01.03.2023)
Get full text
Journal Article
Preparation and humidity sensing properties of Fe-doped mesoporous silica SBA-15
Qi, Qi, Zhang, Tong, Zheng, Xuejun, Wan, Lifeng
Published in Sensors and actuators. B, Chemical (10.12.2008)
Published in Sensors and actuators. B, Chemical (10.12.2008)
Get full text
Journal Article
Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
Get full text
Journal Article
10--4--899A10--7H-[1'2':45][12-B]-35- 10-diphenylmethyl-4-hydroxy-899A10-tetrahydro-7H-pyrollo[1'2':45]pyrazino[12-B]pyridazine-35-dione derivative as the inhibitor of the orthomyxovirus reproduction for the treatment of influenza and related compound
MANNING JAMES R, POON DANIEL, JAIN RAMA, MARX VANESSA, WAN LIFENG, WANG XIAOJING MICHAEL, DAUPHINAIS MAXIME, ZHAO QIAN, YIFRU AREGAHEGN, KOESTER DENNIS CHRISTOFER
Year of Publication 24.05.2024
Get full text
Year of Publication 24.05.2024
Patent
10-(DI(PHENYL)METHYL)-4-HYDROXY-8,9,9a,10-TETRAHYDRO-7H-PYRROLO[1',2':4,5]PYRAZINO[1,2-b]PYRIDAZINE-3,5-DIONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF ORTHOMYXOVIRUS REPLICATION FOR TREATING INFLUENZA
MAXIME DAUPHINAIS, VANESSA MARX, POON DANIEL, DENNIS CHRISTOFER KOESTER, JAMES R MANNING, WAN LIFENG, XIAOJING MICHAEL WANG, AREGAHEGN YIFRU, ZHAO QIAN, RAMA JAIN
Year of Publication 12.03.2024
Get full text
Year of Publication 12.03.2024
Patent
10--4--899A10--7H-[1'2':45][12-B]-35- 10-diphenylmethyl-4-hydroxy-899A10-tetrahydro-7H-pyrollo[1'2':45]pyrazino[12-B]pyridazine-35-dione derivative as the inhibitor of the orthomyxovirus reproduction for the treatment of influenza and related compound
MANNING JAMES R, POON DANIEL, JAIN RAMA, MARX VANESSA, WAN LIFENG, WANG XIAOJING MICHAEL, DAUPHINAIS MAXIME, ZHAO QIAN, YIFRU AREGAHEGN, KOESTER DENNIS CHRISTOFER
Year of Publication 07.03.2023
Get full text
Year of Publication 07.03.2023
Patent
Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor
Stuart, Darrin D., Shao, Wenlin, Mishina, Yuji, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G., Rivera, Stacey, Shen, Fang, Korn, Joshua, Griner, Lesley A. Mathews, Nishiguchi, Giselle, Taft, Benjamin, Wan, Lifeng, Subramanian, Sharadha, Lou, Yan, Setti, Lina, Burger, Matthew, Tamez, Victor, Rico, Alice, Aversa, Robert, Tellew, John, Haling, Jacob R., Polyakov, Valery, Lambert, Amy, Zang, Richard, Abbema, Ann Van, Hekmat-Nejad, Mohamad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P., Lees, Emma, Sellers, William R., Ramurthy, Savithri
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Analysis of the path for life-cycle information sharing in urban rail transit project
Wan Lifeng, Yin Yilin, Hong, K E
Published in 2010 International Conference on Logistics Systems and Intelligent Management (ICLSIM) (01.01.2010)
Published in 2010 International Conference on Logistics Systems and Intelligent Management (ICLSIM) (01.01.2010)
Get full text
Conference Proceeding
인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10--4-히드록시-8,9,9A,10-테트라히드로-7H-피롤로[1',2':4,5]피라지노[1,2-B]피리다진-3,5-디온 유도체 및 관련 화합물
MANNING JAMES R, POON DANIEL, JAIN RAMA, MARX VANESSA, WAN LIFENG, WANG XIAOJING MICHAEL, DAUPHINAIS MAXIME, ZHAO QIAN, YIFRU AREGAHEGN, KOESTER DENNIS CHRISTOFER
Year of Publication 04.11.2020
Get full text
Year of Publication 04.11.2020
Patent
BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS
HU CHENG, BENJAMIN TAFT, PAUL A BARSANTI, AARON SMITH, NAEEM YUSUFF, ROBERT AVERSA, MICHAEL PATRICK DILLON, VALERY POLYAKOV, WAN LIFENG, PAN YUE, SAVITHRI RAMURTHY, LU YANG, SHARADHA SUBRAMANIAN, LINA SETTI, MATTHEW BURGER, HUW TANNER, ALAN DIPESA, GISELE NISHIGUCHI, ALICE RICO
Year of Publication 10.09.2020
Get full text
Year of Publication 10.09.2020
Patent
BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS
HU CHENG, BENJAMIN TAFT, PAUL A BARSANTI, AARON SMITH, NAEEM YUSUFF, ROBERT AVERSA, MICHAEL PATRICK DILLON, VALERY POLYAKOV, WAN LIFENG, PAN YUE, SAVITHRI RAMURTHY, LU YANG, SHARADHA SUBRAMANIAN, LINA SETTI, MATTHEW BURGER, HUW TANNER, ALAN DIPESA, GISELE NISHIGUCHI, ALICE RICO
Year of Publication 27.09.2018
Get full text
Year of Publication 27.09.2018
Patent
PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS
HU CHENG, LIN XIAODONG, MARTIN SENDZIK, PAUL A BARSANTI, JIN JEFF, WAN LIFENG, PAN YUE, ROBERT KEYES, ROBERT KUCEJKO, KEITH B PFISTER, JAMES SUTTON
Year of Publication 19.03.2015
Get full text
Year of Publication 19.03.2015
Patent