First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors
Hassan, Raffit, Blumenschein, Jr, George R, Moore, Kathleen N, Santin, Alessandro D, Kindler, Hedy L, Nemunaitis, John J, Seward, Shelly M, Thomas, Anish, Kim, Stella K, Rajagopalan, Prabhu, Walter, Annette O, Laurent, Dirk, Childs, Barrett H, Sarapa, Nenad, Elbi, Cem, Bendell, Johanna C
Published in Journal of clinical oncology (01.06.2020)
Published in Journal of clinical oncology (01.06.2020)
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First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity
Postel-Vinay, Sophie, Herbschleb, Karin, Massard, Christophe, Woodcock, Victoria, Soria, Jean-Charles, Walter, Annette O., Ewerton, Flavio, Poelman, Martine, Benson, Neil, Ocker, Matthias, Wilkinson, Gary, Middleton, Mark
Published in European journal of cancer (1990) (01.03.2019)
Published in European journal of cancer (1990) (01.03.2019)
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Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC
Walter, Annette O, Sjin, Robert Tjin Tham, Haringsma, Henry J, Ohashi, Kadoaki, Sun, Jing, Lee, Kwangho, Dubrovskiy, Aleksandr, Labenski, Matthew, Zhu, Zhendong, Wang, Zhigang, Sheets, Michael, St Martin, Thia, Karp, Russell, van Kalken, Dan, Chaturvedi, Prasoon, Niu, Deqiang, Nacht, Mariana, Petter, Russell C, Westlin, William, Lin, Kevin, Jaw-Tsai, Sarah, Raponi, Mitch, Van Dyke, Terry, Etter, Jeff, Weaver, Zoe, Pao, William, Singh, Juswinder, Simmons, Andrew D, Harding, Thomas C, Allen, Andrew
Published in Cancer discovery (01.12.2013)
Published in Cancer discovery (01.12.2013)
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Anetumab ravtansine versus vinorelbine in patients with relapsed, mesothelin-positive malignant pleural mesothelioma (ARCS-M): a randomised, open-label phase 2 trial
Kindler, Hedy L, Novello, Silvia, Bearz, Alessandra, Ceresoli, Giovanni L, Aerts, Joachim G J V, Spicer, James, Taylor, Paul, Nackaerts, Kristiaan, Greystoke, Alastair, Jennens, Ross, Calabrò, Luana, Burgers, Jacobus A, Santoro, Armando, Cedrés, Susana, Serwatowski, Piotr, Ponce, Santiago, Van Meerbeeck, Jan P, Nowak, Anna K, Blumenschein, Jr, George, Siegel, Jonathan M, Kasten, Linda, Köchert, Karl, Walter, Annette O, Childs, Barrett H, Elbi, Cem, Hassan, Raffit, Fennell, Dean A
Published in The lancet oncology (01.04.2022)
Published in The lancet oncology (01.04.2022)
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Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
Graham, Keith, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Naujoks, Jan, Lesche, Ralf, Weiske, Joerg, Kuehnlenz, Julia, Brzezinka, Krzysztof, Potze, Lisette, Zanconato, Francesca, Nicke, Barbara, Montebaur, Anna, Bone, Wilhelm, Golfier, Sven, Kaulfuss, Stefan, Kopitz, Charlotte, Pilari, Sabine, Steuber, Holger, Hayat, Sikander, Kamburov, Atanas, Steffen, Andreas, Schlicker, Andreas, Buchgraber, Philipp, Braeuer, Nico, Font, Nuria Aiguabella, Heinrich, Tobias, Kuhnke, Lara, Nowak-Reppel, Katrin, Stresemann, Carlo, Steigemann, Patrick, Walter, Annette O., Blotta, Simona, Ocker, Matthias, Lakner, Ashley, von Nussbaum, Franz, Mumberg, Dominik, Eis, Knut, Piccolo, Stefano, Lange, Martin
Published in Cell chemical biology (18.07.2024)
Published in Cell chemical biology (18.07.2024)
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Safety and activity of anti-mesothelin antibody–drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study
Santin, Alessandro D, Vergote, Ignace, González-Martín, Antonio, Moore, Kathleen, Oaknin, Ana, Romero, Ignacio, Diab, Sami, Copeland, Larry J, Monk, Bradley J, Coleman, Robert L, Herzog, Thomas J, Siegel, Jonathan, Kasten, Linda, Schlicker, Andreas, Schulz, Anke, Köchert, Karl, Walter, Annette O, Childs, Barrett H, Elbi, Cem, Bulat, Iurie
Published in International journal of gynecological cancer (01.04.2023)
Published in International journal of gynecological cancer (01.04.2023)
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Phase I dose-escalation studies of roniciclib, a pan-cyclin-dependent kinase inhibitor, in advanced malignancies
Bahleda, Rastislav, Grilley-Olson, Juneko E, Govindan, Ramaswamy, Barlesi, Fabrice, Greillier, Laurent, Perol, Maurice, Ray-Coquard, Isabelle, Strumberg, Dirk, Schultheis, Beate, Dy, Grace K, Zalcman, Gérard, Weiss, Glen J, Walter, Annette O, Kornacker, Martin, Rajagopalan, Prabhu, Henderson, David, Nogai, Hendrik, Ocker, Matthias, Soria, Jean-Charles
Published in British journal of cancer (06.06.2017)
Published in British journal of cancer (06.06.2017)
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In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing
Tjin Tham Sjin, Robert, Lee, Kwangho, Walter, Annette O, Dubrovskiy, Aleksandr, Sheets, Michael, Martin, Thia St, Labenski, Matthew T, Zhu, Zhendong, Tester, Richland, Karp, Russell, Medikonda, Aravind, Chaturvedi, Prasoon, Ren, Yixuan, Haringsma, Henry, Etter, Jeff, Raponi, Mitch, Simmons, Andrew D, Harding, Thomas C, Niu, Deqiang, Nacht, Mariana, Westlin, William F, Petter, Russell C, Allen, Andrew, Singh, Juswinder
Published in Molecular cancer therapeutics (01.06.2014)
Published in Molecular cancer therapeutics (01.06.2014)
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Prognosis of patients with malignant mesothelioma by expression of programmed cell death 1 ligand 1 and mesothelin in a contemporary cohort in Finland
Vizcaya, David, Farahmand, Bahman, Walter, Annette O., Kneip, Christoph, Jöhrens, Korinna, Tukiainen, Mikko, Schmitz, Arndt A.
Published in Cancer treatment and research communications (2020)
Published in Cancer treatment and research communications (2020)
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The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation
WALTER, Annette O, SEGHEZZI, Wolfgang, KORVER, Wouter, SHEUNG, Julie, LEES, Emma
Published in Oncogene (05.10.2000)
Published in Oncogene (05.10.2000)
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Inhibition of Cdc7/Dbf4 kinase activity affects specific phosphorylation sites on MCM2 in cancer cells
Charych, Deborah H., Coyne, Mazie, Yabannavar, Asha, Narberes, Jamie, Chow, Sylvia, Wallroth, Marco, Shafer, Cynthia, Walter, Annette O.
Published in Journal of cellular biochemistry (01.06.2008)
Published in Journal of cellular biochemistry (01.06.2008)
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Abstract 3022: BAY 1143572, a first-in-class, highly selective, potent and orally available inhibitor of PTEFb/CDK9 currently in Phase I, shows convincing anti-tumor activity in preclinical models of acute myeloid leukemia (AML)
Scholz, Arne, Oellerich, Thomas, Hussain, Akhtar, Lindner, Sarah, Luecking, Ulrich, Walter, Annette O., Ellinghaus, Peter, Valencia, Ray, von Nussbaum, Franz, Mumberg, Dominik, Brands, Michael, Ince, Stuart, Serve, Hubert, Ziegelbauer, Karl
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma
Krepler, Clemens, Sproesser, Katrin, Brafford, Patricia, Beqiri, Marilda, Garman, Bradley, Xiao, Min, Shannan, Batool, Watters, Andrea, Perego, Michela, Zhang, Gao, Vultur, Adina, Yin, Xiangfan, Liu, Qin, Anastopoulos, Ioannis N., Wubbenhorst, Bradley, Wilson, Melissa A., Xu, Wei, Karakousis, Giorgos, Feldman, Michael, Xu, Xiaowei, Amaravadi, Ravi, Gangadhar, Tara C., Elder, David E., Haydu, Lauren E., Wargo, Jennifer A., Davies, Michael A., Lu, Yiling, Mills, Gordon B., Frederick, Dennie T., Barzily-Rokni, Michal, Flaherty, Keith T., Hoon, Dave S., Guarino, Michael, Bennett, Joseph J., Ryan, Randall W., Petrelli, Nicholas J., Shields, Carol L., Terai, Mizue, Sato, Takami, Aplin, Andrew E., Roesch, Alexander, Darr, David, Angus, Steve, Kumar, Rakesh, Halilovic, Ensar, Caponigro, Giordano, Jeay, Sebastien, Wuerthner, Jens, Walter, Annette, Ocker, Matthias, Boxer, Matthew B., Schuchter, Lynn, Nathanson, Katherine L., Herlyn, Meenhard
Published in Cell reports (Cambridge) (14.11.2017)
Published in Cell reports (Cambridge) (14.11.2017)
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Time to Disability Milestones and Annualized Relapse Rates in NMOSD and MOGAD
Duchow, Ankelien, Bellmann‐Strobl, Judith, Friede, Tim, Aktas, Orhan, Angstwurm, Klemens, Ayzenberg, Ilya, Berthele, Achim, Dawin, Eva, Engels, Daniel, Fischer, Katinka, Flaskamp, Martina, Giglhuber, Katrin, Grothe, Matthias, Havla, Joachim, Hümmert, Martin W., Jarius, Sven, Kaste, Matthias, Kern, Peter, Kleiter, Ingo, Klotz, Luisa, Korporal‐Kuhnke, Mirjam, Kraemer, Markus, Krumbholz, Markus, Kümpfel, Tania, Lohmann, Lisa, Ringelstein, Marius, Rommer, Paulus, Schindler, Patrick, Schubert, Charlotte, Schwake, Carolin, Senel, Makbule, Then Bergh, Florian, Tkachenko, Daria, Tumani, Hayrettin, Trebst, Corinna, Vardakas, Ioannis, Walter, Annette, Warnke, Clemens, Weber, Martin S., Wickel, Jonathan, Wildemann, Brigitte, Winkelmann, Alexander, Paul, Friedemann, Stellmann, Jan‐Patrick, Häußler, Vivien, Duchow, Ankelien, Bellmann‐Strobl, Judith, Friede, Tim, Stellmann, Jan‐Patrick, Häußler, Vivien, Duchow, Ankelien, Bellmann‐Strobl, Judith, Friede, Tim, Ayzenberg, Ilya, Berthele, Achim, Dawin, Eva, Engels, Daniel, Fischer, Katinka, Flaskamp, Martina, Giglhuber, Katrin, Grothe, Matthias, Havla, Joachim, Hümmert, Martin W., Jarius, Sven, Kaste, Matthias, Kern, Peter, Kleiter, Ingo, Klotz, Luisa, Korporal‐Kuhnke, Mirjam, Kraemer, Markus, Krumbholz, Markus, Kümpfel, Tania, Lohmann, Lisa, Ringelstein, Marius, Rommer, Paulus, Schindler, Patrick, Schubert, Charlotte, Schwake, Carolin, Senel, Makbule, Then Bergh, Florian, Tkachenko, Daria, Tumami, Hayrettin, Trebst, Corinna, Vardakas, Ioannis, Walter, Annette, Warnke, Clemens, Weber, Martin S., Wickel, Jonathan, Wildemann, Brigitte, Winkelmann, Alexander, Paul, Friedemann, Stellmann, Jan‐Patrick, Häußler, Vivien, Duchow, Ankelien, Bellmann‐Strobl, Judith, Stellmann, Jan‐Patrick, Häußler, Vivien
Published in Annals of neurology (01.04.2024)
Published in Annals of neurology (01.04.2024)
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Abstract 4816: Anetumab ravtansine has monotherapy efficacy in mesothelin positive patient-derived NSCLC tumor models and in a syngeneic tumor model in immunocompetent mice
Sommer, Anette, Lejeune, Pascale, Hoff, Sabine, Walter, Annette O., Berndt, Sandra, Roese, Lars, Schlicker, Andreas, Wick, Michael J., Elbi, Cem, Mumberg, Dominik, Schatz, Christoph
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Anti-CD20 therapies and pregnancy in neuroimmunologic disorders: A cohort study from Germany
Kümpfel, Tania, Thiel, Sandra, Meinl, Ingrid, Ciplea, Andrea I, Bayas, Antonios, Hoffmann, Frank, Hofstadt-van Oy, Ulrich, Hoshi, Muna, Kluge, Jakob, Ringelstein, Marius, Aktas, Orhan, Stoppe, Muriel, Walter, Annette, Weber, Martin S, Ayzenberg, Ilya, Hellwig, Kerstin
Published in Neurology : neuroimmunology & neuroinflammation (01.01.2021)
Published in Neurology : neuroimmunology & neuroinflammation (01.01.2021)
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