Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells
Seifert, Tina, Malo, Marcus, Kokkola, Tarja, Engen, Karin, Fridén-Saxin, Maria, Wallén, Erik A. A, Lahtela-Kakkonen, Maija, Jarho, Elina M, Luthman, Kristina
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
5‑Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions
Pätsi, Henri T., Kilpeläinen, Tommi P., Jumppanen, Mikael, Uhari-Väänänen, Johanna, Wielendaele, Pieter Van, De Lorenzo, Francesca, Cui, Hengjing, Auno, Samuli, Saharinen, Janne, Seppälä, Erin, Sipari, Nina, Savinainen, Juha, De Meester, Ingrid, Lambeir, Anne-Marie, Lahtela-Kakkonen, Maija, Myöhänen, Timo T., Wallén, Erik A. A.
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Journal Article
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease
Kilpeläinen, Tommi P., Pätsi, Henri T., Svarcbahs, Reinis, Julku, Ulrika H., Eteläinen, Tony S., Cui, Hengjing, Auno, Samuli, Sipari, Nina, Norrbacka, Susanna, Leino, Teppo O., Jäntti, Maria, Myöhänen, Timo T., Wallén, Erik A. A.
Published in Journal of medicinal chemistry (08.06.2023)
Published in Journal of medicinal chemistry (08.06.2023)
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Journal Article
Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors
Huhtiniemi, Tero, Suuronen, Tiina, Rinne, Valtteri M, Wittekindt, Carsten, Lahtela-Kakkonen, Maija, Jarho, Elina, Wallén, Erik A. A, Salminen, Antero, Poso, Antti, Leppänen, Jukka
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
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Journal Article
The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy
Kilpeläinen, Tommi P., Hellinen, Laura, Vrijdag, Johannes, Yan, Xu, Svarcbahs, Reinis, Vellonen, Kati-Sisko, Lambeir, Anne-Marie, Huttunen, Henri, Urtti, Arto, Wallen, Erik A.A, Myöhänen, Timo T.
Published in Biomedicine & pharmacotherapy (01.08.2020)
Published in Biomedicine & pharmacotherapy (01.08.2020)
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Journal Article
The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery
Leino, Teppo O., Sieger, Peter, Yli-Kauhaluoma, Jari, Wallén, Erik A.A., Kley, Jörg T.
Published in European journal of medicinal chemistry (05.07.2022)
Published in European journal of medicinal chemistry (05.07.2022)
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Journal Article
Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists
Leino, Teppo O., Turku, Ainoleena, Urvas, Lauri, Adhikari, Karuna, Oksanen, Jouni, Steynen, Yana, Yli-Kauhaluoma, Jari, Xhaard, Henri, Kukkonen, Jyrki P., Wallén, Erik A.A.
Published in Bioorganic & medicinal chemistry (06.06.2023)
Published in Bioorganic & medicinal chemistry (06.06.2023)
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Journal Article
2‑Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
Pätsi, Henri T, Kilpeläinen, Tommi P, Auno, Samuli, Dillemuth, Pyry M. J, Arja, Khaled, Lahtela-Kakkonen, Maija K, Myöhänen, Timo T, Wallén, Erik A. A
Published in ACS medicinal chemistry letters (14.10.2021)
Published in ACS medicinal chemistry letters (14.10.2021)
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Journal Article
Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors
Kilpeläinen, Tommi P, Tyni, Jonna K, Lahtela-Kakkonen, Maija K, Eteläinen, Tony S, Myöhänen, Timo T, Wallén, Erik A. A
Published in ACS medicinal chemistry letters (12.12.2019)
Published in ACS medicinal chemistry letters (12.12.2019)
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Journal Article
Azulene-based compounds for targeting orexin receptors
Leino, Teppo O., Turku, Ainoleena, Yli-Kauhaluoma, Jari, Kukkonen, Jyrki P., Xhaard, Henri, Wallén, Erik A.A.
Published in European journal of medicinal chemistry (05.09.2018)
Published in European journal of medicinal chemistry (05.09.2018)
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Journal Article
A scaffold replacement approach towards new sirtuin 2 inhibitors
Seifert, Tina, Malo, Marcus, Kokkola, Tarja, Stéen, E. Johanna L., Meinander, Kristian, Wallén, Erik A.A., Jarho, Elina M., Luthman, Kristina
Published in Bioorganic & medicinal chemistry (15.01.2020)
Published in Bioorganic & medicinal chemistry (15.01.2020)
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Journal Article
Synthesis of 2,3,6,8-Tetrasubstituted Chromone Scaffolds
Dahlén, Kristian, Wallén, Erik A. A, Grøtli, Morten, Luthman, Kristina
Published in Journal of organic chemistry (01.09.2006)
Published in Journal of organic chemistry (01.09.2006)
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Journal Article
Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26
Rinne, Maiju K., Leino, Teppo O., Turku, Ainoleena, Turunen, Pauli M., Steynen, Yana, Xhaard, Henri, Wallén, Erik A.A., Kukkonen, Jyrki P.
Published in European journal of pharmacology (15.10.2018)
Published in European journal of pharmacology (15.10.2018)
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Journal Article
Stapled truncated orexin peptides as orexin receptor agonists
Karhu, Lasse, Weisell, Janne, Turunen, Pauli M., Leino, Teppo O., Pätsi, Henri, Xhaard, Henri, Kukkonen, Jyrki P., Wallén, Erik A.A.
Published in Peptides (New York, N.Y. : 1980) (01.04.2018)
Published in Peptides (New York, N.Y. : 1980) (01.04.2018)
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Journal Article
Synthesis of Orthogonally Protected Disulfide Bridge Mimetics
Tadd, Andrew C, Meinander, Kristian, Luthman, Kristina, Wallén, Erik A. A
Published in Journal of organic chemistry (21.01.2011)
Published in Journal of organic chemistry (21.01.2011)
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Journal Article
N,N‘-Bisbenzylidenebenzene-1,4-diamines and N,N‘-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors
Kiviranta, Päivi H, Leppänen, Jukka, Kyrylenko, Sergiy, Salo, Heikki S, Lahtela-Kakkonen, Maija, Tervo, Anu J, Wittekindt, Carsten, Suuronen, Tiina, Kuusisto, Erkki, Järvinen, Tomi, Salminen, Antero, Poso, Antti, Wallén, Erik A. A
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
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Journal Article
Utilization of whole health services among veterans with spinal cord injuries and disorders (SCI/D): Early insights from the VA SCI/D system of care
Wallen, Erik S., Sippel, Jennifer L., Park, Meaghan E., Etingen, Bella, Weaver, Frances M., Hogan, Timothy P., Smith, Bridget M., Bokhour, Barbara G., Wickremasinghe, Itala M.
Published in The journal of spinal cord medicine (2024)
Published in The journal of spinal cord medicine (2024)
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Journal Article
Chroman-4-one and chromone based somatostatin β-turn mimetics
Fridén-Saxin, Maria, Seifert, Tina, Malo, Marcus, da Silva Andersson, Krystle, Pemberton, Nils, Dyrager, Christine, Friberg, Annika, Dahlén, Kristian, Wallén, Erik A.A., Grøtli, Morten, Luthman, Kristina
Published in European journal of medicinal chemistry (23.05.2016)
Published in European journal of medicinal chemistry (23.05.2016)
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Journal Article
Replacement of the Disulfide Bridge in a KLK3-Stimulating Peptide Using Orthogonally Protected Building Blocks
Meinander, Kristian, Pakkala, Miikka, Weisell, Janne, Stenman, Ulf-Håkan, Koistinen, Hannu, Närvänen, Ale, Wallén, Erik A. A
Published in ACS medicinal chemistry letters (13.02.2014)
Published in ACS medicinal chemistry letters (13.02.2014)
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Journal Article
Synthesis of 3-Aminomethyl-2-aryl- 8-bromo-6-chlorochromones
Wallén, Erik A. A, Dahlén, Kristian, Grøtli, Morten, Luthman, Kristina
Published in Organic letters (01.02.2007)
Published in Organic letters (01.02.2007)
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