Structural Basis and Kinetic Pathway of RBM39 Recruitment to DCAF15 by a Sulfonamide Molecular Glue E7820
Du, Xinlin, Volkov, Oleg A., Czerwinski, Robert M., Tan, HuiLing, Huerta, Carlos, Morton, Emily R., Rizzi, Jim P., Wehn, Paul M., Xu, Rui, Nijhawan, Deepak, Wallace, Eli M.
Published in Structure (London) (05.11.2019)
Published in Structure (London) (05.11.2019)
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Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma
Courtney, Kevin D, Infante, Jeffrey R, Lam, Elaine T, Figlin, Robert A, Rini, Brian I, Brugarolas, James, Zojwalla, Naseem J, Lowe, Ann M, Wang, Keshi, Wallace, Eli M, Josey, John A, Choueiri, Toni K
Published in Journal of clinical oncology (20.03.2018)
Published in Journal of clinical oncology (20.03.2018)
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On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
Cho, Hyejin, Du, Xinlin, Rizzi, James P., Liberzon, Ella, Chakraborty, Abhishek A., Gao, Wenhua, Carvo, Ingrid, Signoretti, Sabina, Bruick, Richard K., Josey, John A., Wallace, Eli M., Kaelin, William G.
Published in Nature (London) (03.11.2016)
Published in Nature (London) (03.11.2016)
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Chen, Wenfang, Hill, Haley, Christie, Alana, Kim, Min Soo, Holloman, Eboni, Pavia-Jimenez, Andrea, Homayoun, Farrah, Ma, Yuanqing, Patel, Nirav, Yell, Paul, Hao, Guiyang, Yousuf, Qurratulain, Joyce, Allison, Pedrosa, Ivan, Geiger, Heather, Zhang, He, Chang, Jenny, Gardner, Kevin H., Bruick, Richard K., Reeves, Catherine, Hwang, Tae Hyun, Courtney, Kevin, Frenkel, Eugene, Sun, Xiankai, Zojwalla, Naseem, Wong, Tai, Rizzi, James P., Wallace, Eli M., Josey, John A., Xie, Yang, Xie, Xian-Jin, Kapur, Payal, McKay, Renée M., Brugarolas, James
Published in Nature (London) (03.11.2016)
Published in Nature (London) (03.11.2016)
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3‑[(1S,2S,3R)‑2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma
Xu, Rui, Wang, Keshi, Rizzi, James P, Huang, Heli, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Wehn, Paul M, Yang, Hanbiao, Dixon, Darryl D, Czerwinski, Robert M, Du, Xinlin, Ged, Emily L, Han, Guangzhou, Tan, Huiling, Wong, Tai, Xie, Shanhai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.08.2019)
Published in Journal of medicinal chemistry (08.08.2019)
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Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension
Hu, Cheng-Jun, Poth, Jens M, Zhang, Hui, Flockton, Amanda, Laux, Aya, Kumar, Sushil, McKeon, Brittany, Mouradian, Gary, Li, Min, Riddle, Suzette, Pugliese, Steven C, Brown, R Dale, Wallace, Eli M, Graham, Brian B, Frid, Maria G, Stenmark, Kurt R
Published in The European respiratory journal (01.12.2019)
Published in The European respiratory journal (01.12.2019)
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A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma
Wallace, Eli M, Rizzi, James P, Han, Guangzhou, Wehn, Paul M, Cao, Zhaodan, Du, Xinlin, Cheng, Tzuling, Czerwinski, Robert M, Dixon, Darryl D, Goggin, Barry S, Grina, Jonas A, Halfmann, Megan M, Maddie, Melissa A, Olive, Sarah R, Schlachter, Stephen T, Tan, Huiling, Wang, Bin, Wang, Keshi, Xie, Shanhai, Xu, Rui, Yang, Hanbiao, Josey, John A
Published in Cancer research (Chicago, Ill.) (15.09.2016)
Published in Cancer research (Chicago, Ill.) (15.09.2016)
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Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension
Macias, David, Moore, Stephen, Crosby, Alexi, Southwood, Mark, Du, Xinlin, Tan, Huiling, Xie, Shanhai, Vassallo, Arlette, Wood, Alexander J T, Wallace, Eli M, Cowburn, Andrew S
Published in The European respiratory journal (01.03.2021)
Published in The European respiratory journal (01.03.2021)
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Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)‑3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro‑1H‑inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)
Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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Journal Article
Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385)
Wehn, Paul M, Rizzi, James P, Dixon, Darryl D, Grina, Jonas A, Schlachter, Stephen T, Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Cao, Zhaodan, Cheng, Tzuling, Czerwinski, Robert M, Goggin, Barry S, Huang, Heli, Halfmann, Megan M, Maddie, Melissa A, Morton, Emily L, Olive, Sarah R, Tan, Huiling, Xie, Shanhai, Wong, Tai, Josey, John A, Wallace, Eli M
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
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A predictive epilepsy index based on probabilistic classification of interictal spike waveforms
Pfammatter, Jesse A, Bergstrom, Rachel A, Wallace, Eli P, Maganti, Rama K, Jones, Mathew V
Published in PloS one (06.11.2018)
Published in PloS one (06.11.2018)
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Deficits in Behavioral and Neuronal Pattern Separation in Temporal Lobe Epilepsy
Madar, Antoine D, Pfammatter, Jesse A, Bordenave, Jessica, Plumley, Erin I, Ravi, Swetha, Cowie, Michael, Wallace, Eli P, Hermann, Bruce P, Maganti, Rama K, Jones, Mathew V
Published in The Journal of neuroscience (17.11.2021)
Published in The Journal of neuroscience (17.11.2021)
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Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor
YEH, Tammie C, MARSH, Vivienne, MARLOW, Allison, HURLEY, Brian, LYSSIKATOS, Joe, LEE, Patrice A, WINKLER, James D, KOCH, Kevin, WALLACE, Eli, BERNAT, Bryan A, BALLARD, Josh, COLWELL, Heidi, EVANS, Ron J, PARRY, Janet, SMITH, Darin, BRANDHUBER, Barbara J, GROSS, Stefan
Published in Clinical cancer research (01.03.2007)
Published in Clinical cancer research (01.03.2007)
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Histone deacetylase inhibitors restore normal hippocampal synaptic plasticity and seizure threshold in a mouse model of Tuberous Sclerosis Complex
Basu, Trina, O’Riordan, Kenneth J., Schoenike, Barry A., Khan, Nadia N., Wallace, Eli P., Rodriguez, Genesis, Maganti, Rama K., Roopra, Avtar
Published in Scientific reports (27.03.2019)
Published in Scientific reports (27.03.2019)
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A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy
Khan, Nadia, Schoenike, Barry, Basu, Trina, Grabenstatter, Heidi, Rodriguez, Genesis, Sindic, Caleb, Johnson, Margaret, Wallace, Eli, Maganti, Rama, Dingledine, Raymond, Roopra, Avtar
Published in PloS one (31.12.2019)
Published in PloS one (31.12.2019)
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Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator
Hinklin, Ronald J., Baer, Brian R., Boyd, Steven A., Chicarelli, Mark D., Condroski, Kevin R., DeWolf, Walter E., Fischer, John, Frank, Michele, Hingorani, Gary P., Lee, Patrice A., Neitzel, Nickolas A., Pratt, Scott A., Singh, Ajay, Sullivan, Francis X., Turner, Timothy, Voegtli, Walter C., Wallace, Eli M., Williams, Lance, Aicher, Thomas D.
Published in Bioorganic & medicinal chemistry (01.01.2020)
Published in Bioorganic & medicinal chemistry (01.01.2020)
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Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→πAr interaction
Wehn, Paul M., Yang, Song, Grina, Jonas A., Rizzi, James P., Schlachter, Stephen T., Wang, Bin, Xu, Rui, Yang, Hanbiao, Du, Xinlin, Han, Guangzhou, Wang, Keshi, Czerwinski, Robert M., Ged, Emily L., Huang, Heli, Halfmann, Megan M., Maddie, Melissa A., Morton, Emily R., Olive, Sarah R., Tan, Huiling, Xie, Shanhai, Josey, John A., Wallace, Eli M.
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation
Davies, Kurtis D., Cable, P. LouAnn, Garrus, Jennifer E., Sullivan, Francis X., von Carlowitz, Ira, Huerou, Yvan Le, Wallace, Eli, Woessner, Richard D., Gross, Stefan
Published in Cancer biology & therapy (01.11.2011)
Published in Cancer biology & therapy (01.11.2011)
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