Manufacturing of [(14)C]-Labeled Drug Substance and Drug Product Utilized in Clinical Research: A Case Study of Omecamtiv Mecarbil
Roberts, Scott W, Bezemer, Jeroen M, Kennedy, Michael T, Correll, Tiffany L, Subramanian, Raju, Walker, Shawn D
Published in Current pharmaceutical design (01.02.2016)
Published in Current pharmaceutical design (01.02.2016)
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Catalytic Asymmetric Synthesis of a Tertiary Benzylic Carbon Center via Phenol-Directed Alkene Hydrogenation
Caille, Seb, Crockett, Rich, Ranganathan, Krishnakumar, Wang, Xiang, Woo, Jacqueline C. S, Walker, Shawn D
Published in Journal of organic chemistry (01.07.2011)
Published in Journal of organic chemistry (01.07.2011)
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Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroED
de Moraes, Lygia Silva, Burch, Jessica E., Delgadillo, David A., Rodriguez, Isabel Hernandez, Mai, Huanghao, Smith, Austin G., Caille, Seb, Walker, Shawn D., Wurz, Ryan P., Cee, Victor J., Rodriguez, Jose A., Gostovic, Dan, Quasdorf, Kyle, Nelson, Hosea M.
Published in Organic letters (23.08.2024)
Published in Organic letters (23.08.2024)
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Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead
Beaver, Matthew G, Shi, Xianqing, Riedel, Jan, Patel, Parth, Zeng, Alicia, Corbett, Michael T, Robinson, Jo Anna, Parsons, Andrew T, Cui, Sheng, Baucom, Kyle, Lovette, Michael A, Içten, Elçin, Brown, Derek B, Allian, Ayman, Flick, Tawnya G, Chen, Wendy, Yang, Ning, Walker, Shawn D
Published in Organic process research & development (17.04.2020)
Published in Organic process research & development (17.04.2020)
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Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes
Tom, Janine K, Achmatowicz, Michal M, Beaver, Matthew G, Colyer, John, Ericson, Ari, Hwang, Tsang-Lin, Jiao, Nancy, Langille, Neil F, Liu, Min, Lovette, Michael A, Sangodkar, Rahul P, Sharvan Kumar, Srividya, Spada, Simone, Perera, Damith, Sheeran, Jillian, Campbell, Kiersten, Doherty, Timothy, Ford, David D, Fang, Yuan-Qing, Rossi, Emiliano, Santoni, Gabriella, Cui, Sheng, Walker, Shawn D
Published in Organic process research & development (19.03.2021)
Published in Organic process research & development (19.03.2021)
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Development of a Commercial Process To Prepare AMG 232 Using a Green Ozonolysis–Pinnick Tandem Transformation
Cochran, Brian M, Corbett, Michael T, Correll, Tiffany L, Fang, Yuan-Qing, Flick, Tawnya G, Jones, Siân C, Silva Elipe, Maria V, Smith, Austin G, Tucker, John L, Vounatsos, Filisaty, Wells, Greg, Yeung, David, Walker, Shawn D, Bio, Matthew M, Caille, Seb
Published in Journal of organic chemistry (19.04.2019)
Published in Journal of organic chemistry (19.04.2019)
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Continuous Process Improvement in the Manufacture of Carfilzomib, Part 1: Process Understanding and Improvements in the Commercial Route to Prepare the Epoxyketone Warhead
Dornan, Peter K, Anthoine, Travis, Beaver, Matthew G, Cheng, Guilong Charles, Cohen, Dawn E, Cui, Sheng, Lake, William E, Langille, Neil F, Lucas, Susan P, Patel, Jenil, Roberts, Scott W, Scardino, Chris, Tucker, John L, Spada, Simone, Zeng, Alicia, Walker, Shawn D
Published in Organic process research & development (17.04.2020)
Published in Organic process research & development (17.04.2020)
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Journal Article
Development of a Factory Process for Omecamtiv Mecarbil, a Novel Cardiac Myosin Activator
Caille, Seb, Allgeier, Alan M, Bernard, Charles, Correll, Tiffany L, Cosbie, Andrew, Crockett, Richard D, Cui, Sheng, Faul, Margaret M, Hansen, Karl B, Huggins, Seth, Langille, Neil, Mennen, Steven M, Morgan, Bradley P, Morrison, Henry, Muci, Alexander, Nagapudi, Karthik, Quasdorf, Kyle, Ranganathan, Krishnakumar, Roosen, Philipp, Shi, Xianqing, Thiel, Oliver R, Wang, Fang, Tvetan, Justin T, Woo, Jacqueline C. S, Wu, Steven, Walker, Shawn D
Published in Organic process research & development (16.08.2019)
Published in Organic process research & development (16.08.2019)
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Journal Article
Correlation of Drug Substance Particle Size Distribution with Other Bulk Properties to Predict Critical Quality Attributes
Morrison, Henry G, Tao, Wenle, Trieu, William, Walker, Shawn D, Cui, Sheng, Huggins, Seth, Nagapudi, Karthik
Published in Organic process research & development (18.09.2015)
Published in Organic process research & development (18.09.2015)
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Discovery of Holocene millennial climate cycles in the Asian continental interior: Has the sun been governing the continental climate?
Kravchinsky, Vadim A., Langereis, Cor G., Walker, Shawn D., Dlusskiy, Konstantin G., White, Dustin
Published in Global and planetary change (01.11.2013)
Published in Global and planetary change (01.11.2013)
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Conference Proceeding
Development of a Scalable Synthesis of a GPR40 Receptor Agonist
Walker, Shawn D, Borths, Christopher J, DiVirgilio, Evan, Huang, Liang, Liu, Pingli, Morrison, Henry, Sugi, Kiyoshi, Tanaka, Masahide, Woo, Jacqueline C. S, Faul, Margaret M
Published in Organic process research & development (20.05.2011)
Published in Organic process research & development (20.05.2011)
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Practical Asymmetric Conjugate Alkynylation of Meldrum’s Acid-Derived Acceptors: Access to Chiral β-Alkynyl Acids
Cui, Sheng, Walker, Shawn D, Woo, Jacqueline C. S, Borths, Christopher J, Mukherjee, Herschel, Chen, Maosheng J, Faul, Margaret M
Published in Journal of the American Chemical Society (20.01.2010)
Published in Journal of the American Chemical Society (20.01.2010)
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Development of a Suitable Salt Form for a GPR40 Receptor Agonist
Morrison, Henry, Jona, Jonan, Walker, Shawn D, Woo, Jacqueline C. S, Li, Lan, Fang, Jan
Published in Organic process research & development (21.01.2011)
Published in Organic process research & development (21.01.2011)
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