Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism
Zanin-Zhorov, Alexandra, Weiss, Jonathan M., Nyuydzefe, Melanie S., Chen, Wei, Scher, Jose U., Mo, Rigen, Depoil, David, Rao, Nishta, Liu, Ben, Wei, Jianlu, Lucas, Sarah, Koslow, Matthew, Roche, Maria, Schueller, Olivier, Weiss, Sara, Poyurovsky, Masha V., Tonra, James, Hippen, Keli L, Dustin, Michael L., Blazar, Bruce R., Liu, Chuan-ju, Waksal, Samuel D., Dinarello, Charles A.
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (25.11.2014)
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ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells
Chen, Wei, Nyuydzefe, Melanie S, Weiss, Jonathan M, Zhang, Jingya, Waksal, Samuel D, Zanin-Zhorov, Alexandra
Published in Scientific reports (09.11.2018)
Published in Scientific reports (09.11.2018)
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Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
Flynn, Ryan, Paz, Katelyn, Du, Jing, Reichenbach, Dawn K., Taylor, Patricia A., Panoskaltsis-Mortari, Angela, Vulic, Ante, Luznik, Leo, MacDonald, Kelli K.P., Hill, Geoffrey R., Nyuydzefe, Melanie S., Weiss, Jonathan M., Chen, Wei, Trzeciak, Alissa, Serody, Jon S., Aguilar, Ethan G., Murphy, William J., Maillard, Ivan, Munn, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, Waksal, Samuel D., Zanin-Zhorov, Alexandra, Blazar, Bruce R.
Published in Blood (28.04.2016)
Published in Blood (28.04.2016)
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Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism
Zanin-Zhorov, Alexandra, Chen, Wei, Moretti, Julien, Nyuydzefe, Melanie S, Zhorov, Iris, Munshi, Rashmi, Ghosh, Malavika, Serdjebi, Cindy, MacDonald, Kelli, Blazar, Bruce R, Palmer, Melissa, Waksal, Samuel D
Published in Communications biology (18.11.2023)
Published in Communications biology (18.11.2023)
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Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10
Zanin-Zhorov, Alexandra, Weiss, Jonathan M, Trzeciak, Alissa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie S, Arencibia, Carmen, Polimera, Seetharam, Schueller, Olivier, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen M, Kunjravia, Norma, Cueto, Inna, Soung, Jennifer, Fleischmann, Roy M, Kivitz, Alan, Lebwohl, Mark, Nunez, Margarita, Woodson, Johnnie, Smith, Shondra L, West, Robert F, Berger, Mark, Krueger, James G, Ryan, John L, Waksal, Samuel D
Published in The Journal of immunology (1950) (15.05.2017)
Published in The Journal of immunology (1950) (15.05.2017)
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ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings
Weiss, Jonathan M, Chen, Wei, Nyuydzefe, Melanie S, Trzeciak, Alissa, Flynn, Ryan, Tonra, James R, Marusic, Suzana, Blazar, Bruce R, Waksal, Samuel D, Zanin-Zhorov, Alexandra
Published in Science signaling (19.07.2016)
Published in Science signaling (19.07.2016)
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The selective ROCK2 inhibitor KD025 reduces IL‐17 secretion in human peripheral blood mononuclear cells independent of IL‐1 and IL‐6
Tengesdal, Isak W., Kitzenberg, David, Li, Suzhao, Nyuydzefe, Melanie S., Chen, Wei, Weiss, Jonathan M., Zhang, Jingya, Waksal, Samuel D., Zanin‐Zhorov, Alexandra, Dinarello, Charles A.
Published in European journal of immunology (01.10.2018)
Published in European journal of immunology (01.10.2018)
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Isoform-specific targeting of ROCK proteins in immune cells
Zanin-Zhorov, Alexandra, Flynn, Ryan, Waksal, Samuel D., Blazar, Bruce R.
Published in Small GTPases (02.07.2016)
Published in Small GTPases (02.07.2016)
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알츠하이머병 및 기타 신경 퇴행성 질환의 치료를 위한 레트로머의 안정화
WAKSAL SAMUEL D, PETSKO GREGORY, COX REBECCA, SMALL SCOTT A, FORBES ALEXANDRIA, QURESHI YASIR H
Year of Publication 15.11.2022
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Year of Publication 15.11.2022
Patent
RETROMER REPLETION WITH AAV9-VPS35 RESTORES ENDOSOMAL FUNCTION IN THE MOUSE HIPPOCAMPUS
Qureshi, Yasir H., Berman, Diego E., Klein, Ronald L., Patel, Vivek M., Simoes, Sabrina, Kannan, Suvarnambiga, Cox, Rebecca, Waksal, Samuel D., Stevens, Beth, Petsko, Gregory A., Small, Scott A.
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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P4‐694: RETROMER REPLETION WITH AAV9‐VPS35 RESTORES ENDOSOMAL FUNCTION IN THE MOUSE HIPPOCAMPUS
Qureshi, Yasir H., Berman, Diego E., Klein, Ronald L., Patel, Vivek M., Simoes, Sabrina, Kannan, Suvarnambiga, Cox, Rebecca, Waksal, Samuel D., Stevens, Beth, Petsko, Gregory A., Small, Scott A.
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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Selective oral ROCK2 inhibitor reduces clinical scores in patients with Psoriasis Vulgaris and normalizes skin pathology via concurrent regulation of IL-17 and IL-10 levels
Zanin-Zhorov, Alexandra, Weiss, Jonathan M, Trzeciak, Alyssa, Chen, Wei, Zhang, Jingya, Nyuydzefe, Melanie, Arencibia, Carmen, Polimera, Seetharam, Fuentes-Duculan, Judilyn, Bonifacio, Kathleen, Kunjravia, Norma, Cueto, Inna, Berger, Mark, Krueger, James, Ryan, John L, Waksal, Samuel D
Published in The Journal of immunology (1950) (01.05.2017)
Published in The Journal of immunology (1950) (01.05.2017)
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Abstract 2590: KD019: Blood brain barrier penetrant HER2/neu, Src, and EGFR inhibitor
Tonra, James R., Poyurovsky, Masha, Liu, Kevin G., Patel, Jeegar, Rao, Nishta, Tilton, Robert, Ryan, John L., Berger, Mark S., Witte, Larry, Kim, Ji-In, Waksal, Samuel D.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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P4‐694: RETROMER REPLETION WITH AAV9‐VPS35 RESTORES ENDOSOMAL FUNCTION IN THE MOUSE HIPPOCAMPUS
Qureshi, Yasir H., Berman, Diego E., Klein, Ronald L., Patel, Vivek M., Simoes, Sabrina, Kannan, Suvarnambiga, Cox, Rebecca, Waksal, Samuel D., Stevens, Beth, Petsko, Gregory A., Small, Scott A.
Published in Alzheimer's & dementia (01.07.2019)
Published in Alzheimer's & dementia (01.07.2019)
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