Cyclic hexapeptide endothelin receptor antagonists highly potent for both receptor subtypes ETA and ETB
KIKUCHI, T, OHTAKI, T, WAKIMASU, M, FUJINO, M, KAWATA, A, IMADA, T, ASAMI, T, MASUDA, Y, SUGO, T, KUSUMOTO, K, KUBO, K, WATANABE, T
Published in Biochemical and biophysical research communications (16.05.1994)
Published in Biochemical and biophysical research communications (16.05.1994)
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Effects of a Potent, Nonselective Endothelin Receptor Antagonist, [Thr18, γ-MeLeu19]-Endothelin-1, on the Isolated Blood Vessels
Karaki, H., Sudjarwo, S.A., Shimamoto, N., Wakimasu, M., Fujino, M.
Published in Biochemical and biophysical research communications (17.07.1995)
Published in Biochemical and biophysical research communications (17.07.1995)
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Receptor binding and antagonist properties of a novel endothelin receptor antagonist, TAK-044 [cyclo[D-alpha-aspartyl-3-[(4-phenylpiperazin-1-yl) carbonyl]-L-alanyl-L-alpha-aspartyl-D-2-(2-thienyl) glycyl-L-leucyl-D-tryptophyl]disodium salt], in human endothelinA and endothelinB receptors
Masuda, Y, Sugo, T, Kikuchi, T, Kawata, A, Satoh, M, Fujisawa, Y, Itoh, Y, Wakimasu, M, Ohtaki, T
Published in The Journal of pharmacology and experimental therapeutics (01.11.1996)
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Published in The Journal of pharmacology and experimental therapeutics (01.11.1996)
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A new endothelin receptor antagonist, TAK-044, shows long-lasting inhibition of both ETA- and ETB-mediated blood pressure responses in rats
Ikeda, S, Awane, Y, Kusumoto, K, Wakimasu, M, Watanabe, T, Fujino, M
Published in The Journal of pharmacology and experimental therapeutics (01.08.1994)
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Published in The Journal of pharmacology and experimental therapeutics (01.08.1994)
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A practical synthesis of the chronic renal disease agent, 4,5-dihydro-3H-1,4,8b-triazaacenaphthylen-3-one derivatives, using regioselective chlorination of ethyl 5-methylimidazo[1,2-a]pyridine-3-carboxy with N-chlorosuccinimide
Ikemoto, T, Kawamoto, T, Tomimatsu, K, Takatani, M, Wakimasu, M
Published in Tetrahedron (29.09.2000)
Published in Tetrahedron (29.09.2000)
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Convenient efficient synthesis of TAK-779, a nonpeptide CCR5 antagonist: development of preparation of various ammonium salts using trialkylphosphite and N-halogenosuccinimide
Ikemoto, Tomomi, Nishiguchi, Atsuko, Mitsudera, Hiroyuki, Wakimasu, Mitsuhiro, Tomimatsu, Kiminori
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Published in Tetrahedron (18.02.2001)
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l-aspartyl-aminomalonic acid diesters: A new group of compounds with intense sweetness
Fujino, M., Wakimasu, M., Tanaka, K., Aoki, H., Nakajima, N.
Published in Die Naturwissenschaften (01.07.1973)
Published in Die Naturwissenschaften (01.07.1973)
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Pharmacology of a non‐selective ETA and ETB receptor antagonist, TAK‐044 and the inhibition of myocardial infarct size in rats
Watanabe, Toshifumi, Awane, Yumiko, Ikeda, Shota, Fujiwara, Shuji, Kubo, Kazuki, Kikuchi, Takashi, Kusumoto, Keiji, Wakimasu, Mitsuhiro, Fujino, Masahiko
Published in British journal of pharmacology (01.03.1995)
Published in British journal of pharmacology (01.03.1995)
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Large-scale synthesis of new cyclazines, 5-thia-1,8b-diazaacenaphthylene-3-carboxylic acid derivatives having the peripheral 12 pi-electron ring system
Ikemoto, T, Kawamoto, T, Wada, H, Ishida, T, Ito, T, Isogami, Y, Miyano, Y, Mizuno, Y, Tomimatsu, K, Hamamura, K, Takatani, M, Wakimasu, M
Published in Tetrahedron (14.01.2002)
Published in Tetrahedron (14.01.2002)
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Process Development of 4-[N-Methyl-N-(tetrahydropyran-4-yl)aminomethyl]aniline Dihydrochloride: A Key Intermediate for TAK-779, a Small-Molecule Nonpeptide CCR5 Antagonist
Hashimoto, Hideo, Ikemoto, Tomomi, Itoh, Tatsuya, Maruyama, Hideaki, Hanaoka, Tadashi, Wakimasu, Mitsuhiro, Mitsudera, Hiroyuki, Tomimatsu, Kiminori
Published in Organic process research & development (01.01.2002)
Published in Organic process research & development (01.01.2002)
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Practical Synthesis of Low-Density Lipoprotein Receptor Upregulator, N-[1-(3-Phenylpropane-1-yl)piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4- carboxamide
Ito, Tatsuya, Ikemoto, Tomomi, Isogami, Yasushi, Wada, Hiroki, Sera, Misayo, Mizuno, Yukio, Wakimasu, Mitsuhiro
Published in Organic process research & development (17.05.2002)
Published in Organic process research & development (17.05.2002)
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Development of a New Synthetic Route of a Non-Peptide CCR5 Antagonist, TAK-779, for Large-Scale Preparation
Ikemoto, Tomomi, Ito, Tatsuya, Hashimoto, Hideo, Kawarasaki, Tadao, Nishiguchi, Atsuko, Mitsudera, Hiroyuki, Wakimasu, Mitsuhiro, Tomimatsu, Kiminori
Published in Organic process research & development (01.11.2000)
Published in Organic process research & development (01.11.2000)
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Effects of a new endothelin antagonist, TAK-044, on post-ischemic acute renal failure in rats
Kusumoto, Keiji, Kubo, Kazuki, Kandori, Hitoshi, Kitayoshi, Takahito, Sato, Shuzo, Wakimasu, Mitsuhiro, Watanabe, Toshifumi, Fujino, Masahiko
Published in Life sciences (1973) (1994)
Published in Life sciences (1973) (1994)
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Cystoid Macular Edema after Descemet's Stripping Automated Endothelial Keratoplasty
Kitazawa, Koji, MD, PhD, Kayukawa, Kanae, MD, Wakimasu, Koichi, MD, Yokota, Isao, PhD, MPH, Inatomi, Tsutomu, MD, PhD, Hieda, Osamu, MD, PhD, Mori, Kazuhiko, MD, PhD, Sotozono, Chie, MD, PhD, Kinoshita, Shigeru, MD, PhD
Published in Ophthalmology (Rochester, Minn.) (01.04.2017)
Published in Ophthalmology (Rochester, Minn.) (01.04.2017)
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Effects of a potent, non-selective endothelin receptor antagonist, [Thr18, gamma-MeLeu19]-endothelin-1, on the isolated blood vessels
Karaki, H, Sudjarwo, S A, Shimamoto, N, Wakimasu, M, Fujino, M
Published in Biochemical and biophysical research communications (17.07.1995)
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Published in Biochemical and biophysical research communications (17.07.1995)
Journal Article
Antagonist activity of [Thr 18,γ-methylleucine 19]endothelin-1 in human endothelin receptors
Masuda, Yasushi, Sugo, Tsukasa, Kikuchi, Takashi, Satoh, Mioko, Fujisawa, Yukio, Itoh, Yasuaki, Wakimasu, Mitsuhiro, Ohtaki, Tetsuya
Published in European journal of pharmacology (01.05.1997)
Published in European journal of pharmacology (01.05.1997)
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Endothelin-1 analogues substituted at both position 18 and 19: highly potent endothelin antagonists with no selectivity for either receptor subtype ETA or ETB
Kikuchi, Takashi, Kubo, Kazuki, Ohtaki, Tetsuya, Suzuki, Nobuhiro, Asami, Taiji, Shimamoto, Norio, Wakimasu, Mitsuhiro, Fujino, Masahiko
Published in Journal of medicinal chemistry (01.12.1993)
Published in Journal of medicinal chemistry (01.12.1993)
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Evidence that dynorphin-(1-13) acts as an agonist on opioid kappa-receptors
Oka, T, Negishi, K, Suda, M, Sawa, A, Fujino, M, Wakimasu, M
Published in European journal of pharmacology (22.01.1982)
Published in European journal of pharmacology (22.01.1982)
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Cyclic Hexapeptide Endothelin Receptor Antagonists Highly Potent for Both Receptor Subtypes ET A and ET B
Kikuchi, T., Ohtaki, T., Kawata, A., Imada, T., Asami, T., Masuda, Y., Sugo, T., Kusumoto, K., Kubo, K., Watanabe, T., Wakimasu, M., Fujino, M.
Published in Biochemical and biophysical research communications (1994)
Published in Biochemical and biophysical research communications (1994)
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