The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma
Laszlo, Viktoria, Valko, Zsuzsanna, Ozsvar, Judit, Kovacs, Ildiko, Garay, Tamas, Hoda, Mir Alireza, Klikovits, Thomas, Stockhammer, Paul, Aigner, Clemens, Gröger, Marion, Klepetko, Walter, Berger, Walter, Grusch, Michael, Tovari, Jozsef, Waizenegger, Irene C., Dome, Balazs, Hegedus, Balazs
Published in Journal of molecular medicine (Berlin, Germany) (01.02.2019)
Published in Journal of molecular medicine (Berlin, Germany) (01.02.2019)
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Journal Article
T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity
Canel, Marta, Taggart, David, Sims, Andrew H, Lonergan, David W, Waizenegger, Irene C, Serrels, Alan
Published in eLife (21.01.2020)
Published in eLife (21.01.2020)
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Journal Article
A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode: High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation
Waizenegger, Irene C, Baum, Anke, Steurer, Steffen, Stadtmüller, Heinz, Bader, Gerd, Schaaf, Otmar, Garin-Chesa, Pilar, Schlattl, Andreas, Schweifer, Norbert, Haslinger, Christian, Colbatzky, Florian, Mousa, Sien, Kalkuhl, Arno, Kraut, Norbert, Adolf, Günther R
Published in Molecular cancer therapeutics (01.03.2016)
Published in Molecular cancer therapeutics (01.03.2016)
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Journal Article
The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer
Tiede, Stefanie, Meyer-Schaller, Nathalie, Kalathur, Ravi Kiran Reddy, Ivanek, Robert, Fagiani, Ernesta, Schmassmann, Philip, Stillhard, Patrick, Häfliger, Simon, Kraut, Norbert, Schweifer, Norbert, Waizenegger, Irene C, Bill, Ruben, Christofori, Gerhard
Published in Oncogenesis (New York, NY) (20.09.2018)
Published in Oncogenesis (New York, NY) (20.09.2018)
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Journal Article
Combination of two novel blocking antibodies, anti-PD-1 antibody ezabenlimab (BI 754091) and anti-LAG-3 antibody BI 754111, leads to increased immune cell responses
Zettl, Markus, Wurm, Melanie, Schaaf, Otmar, Mostböck, Sven, Tirapu, Iñigo, Apfler, Ilse, Lorenz, Ivo C., Frego, Lee, Kenny, Cynthia, Thibodeau, Michael, Oquendo Cifuentes, Elisa, Reschke, Markus, Moll, Jürgen, Kraut, Norbert, Vogt, Anne, Sedgwick, Jonathon D., Waizenegger, Irene C.
Published in Oncoimmunology (31.12.2022)
Published in Oncoimmunology (31.12.2022)
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Journal Article
Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers
Wilding, Birgit, Woelflingseder, Lydia, Baum, Anke, Chylinski, Krzysztof, Vainorius, Gintautas, Gibson, Neil, Waizenegger, Irene C., Gerlach, Daniel, Augsten, Martin, Spreitzer, Fiona, Shirai, Yukina, Ikegami, Masachika, Tilandyova, Sylvia, Scharn, Dirk, Pearson, Mark A., Popow, Johannes, Obenauf, Anna C., Yamamoto, Noboru, Kondo, Shunsuke, Opdam, Frans L., Bruining, Annemarie, Kohsaka, Shinji, Kraut, Norbert, Heymach, John V., Solca, Flavio, Neumuller, Ralph A.
Published in Cancer discovery (09.09.2024)
Published in Cancer discovery (09.09.2024)
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Journal Article
Two Distinct Pathways Remove Mammalian Cohesin from Chromosome Arms in Prophase and from Centromeres in Anaphase
Waizenegger, Irene C, Hauf, Silke, Meinke, Andreas, Peters, Jan-Michael
Published in Cell (27.10.2000)
Published in Cell (27.10.2000)
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Journal Article
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases
Sini, Patrizia, Gürtler, Ulrich, Zahn, Stephan K, Baumann, Christoph, Rudolph, Dorothea, Baumgartinger, Rosa, Strauss, Eva, Haslinger, Christian, Tontsch-Grunt, Ulrike, Waizenegger, Irene C, Solca, Flavio, Bader, Gerd, Zoephel, Andreas, Treu, Matthias, Reiser, Ulrich, Garin-Chesa, Pilar, Boehmelt, Guido, Kraut, Norbert, Quant, Jens, Adolf, Günther R
Published in Molecular cancer therapeutics (01.10.2016)
Published in Molecular cancer therapeutics (01.10.2016)
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Journal Article
Efficacy of the highly selective focal adhesion kinase inhibitor BI 853520 in adenocarcinoma xenograft models is linked to a mesenchymal tumor phenotype
Hirt, Ulrich A, Waizenegger, Irene C, Schweifer, Norbert, Haslinger, Christian, Gerlach, Daniel, Braunger, Jürgen, Weyer-Czernilofsky, Ulrike, Stadtmüller, Heinz, Sapountzis, Ioannis, Bader, Gerd, Zoephel, Andreas, Bister, Bojan, Baum, Anke, Quant, Jens, Kraut, Norbert, Garin-Chesa, Pilar, Adolf, Günther R
Published in Oncogenesis (New York, NY) (23.02.2018)
Published in Oncogenesis (New York, NY) (23.02.2018)
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Journal Article
Human Securin Proteolysis Is Controlled by the Spindle Checkpoint and Reveals When the APC/C Switches from Activation by Cdc20 to Cdh1
Hagting, Anja, den Elzen, Nicole, Vodermaier, Hartmut C., Waizenegger, Irene C., Peters, Jan-Michael, Pines, Jonathon
Published in The Journal of cell biology (24.06.2002)
Published in The Journal of cell biology (24.06.2002)
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Journal Article
Polo-like kinase inhibitor volasertib marginally enhances the efficacy of the novel Fc-engineered anti-CD33 antibody BI 836858 in acute myeloid leukemia
Gopalakrishnan, Bhavani, Cheney, Carolyn, Mani, Rajeswaran, Mo, Xiaokui, Bucci, Donna, Walker, Alison, Klisovic, Rebecca, Bhatnagar, Bhavana, Walsh, Katherine, Rueter, Bjoern, Waizenegger, Irene C, Heider, Karl-Heinz, Blum, William, Vasu, Sumithira, Muthusamy, Natarajan
Published in Oncotarget (09.02.2018)
Published in Oncotarget (09.02.2018)
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Journal Article
Inhibition of PLK1 by capped‐dose volasertib exerts substantial efficacy in MDS and sAML while sparing healthy haematopoiesis
Dill, Veronika, Kauschinger, Johanna, Hauch, Richard T., Buschhorn, Lars, Odinius, Timo O., Müller‐Thomas, Catharina, Mishra, Ritu, Kyncl, Michele C., Schmidt, Burkhard, Prodinger, Peter M., Hempel, Dirk, Bellos, Frauke, Höllein, Alexander, Kern, Wolfgang, Haferlach, Torsten, Slotta‐Huspenina, Julia, Bassermann, Florian, Peschel, Christian, Götze, Katharina S., Waizenegger, Irene C., Höckendorf, Ulrike, Jost, Philipp J., Jilg, Stefanie
Published in European journal of haematology (01.02.2020)
Published in European journal of haematology (01.02.2020)
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Journal Article
Regulation of Human Separase by Securin Binding and Autocleavage
Waizenegger, Irene C., Giménez-Abián, Juan F., Wernic, Dominik, Peters, Jan-Michael
Published in Current biology (20.08.2002)
Published in Current biology (20.08.2002)
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Journal Article
The Meiosis I-to-Meiosis II Transition in Mouse Oocytes Requires Separase Activity
Terret, M.Emilie, Wassmann, Katja, Waizenegger, Irene, Maro, Bernard, Peters, Jan-Michael, Verlhac, Marie-Hélène
Published in Current biology (14.10.2003)
Published in Current biology (14.10.2003)
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Journal Article
The Arabidopsis KNOLLE Protein Is a Cytokinesis-Specific Syntaxin
Lauber, Martina H., Waizenegger, Irene, Steinmann, Thomas, Schwarz, Heinz, Mayer, Ulrike, Hwang, Inwhan, Lukowitz, Wolfgang, Jürgens, Gerd
Published in The Journal of cell biology (15.12.1997)
Published in The Journal of cell biology (15.12.1997)
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Journal Article
The Arabidopsis KNOLLE and KEULE genes interact to promote vesicle fusion during cytokinesis
Waizenegger, Irene, Lukowitz, Wolfgang, Assaad, Farhah, Schwarz, Heinz, Jürgens, Gerd, Mayer, Ulrike
Published in Current biology (02.11.2000)
Published in Current biology (02.11.2000)
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Journal Article
Securin Is Required for Chromosomal Stability in Human Cells
Jallepalli, Prasad V., Waizenegger, Irene C., Bunz, Fred, Langer, Sabine, Speicher, Michael R., Peters, Jan-Michael, Kinzler, Kenneth W., Vogelstein, Bert, Lengauer, Christoph
Published in Cell (18.05.2001)
Published in Cell (18.05.2001)
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Journal Article
Scc1/Rad21/Mcd1 Is Required for Sister Chromatid Cohesion and Kinetochore Function in Vertebrate Cells
Sonoda, Eiichiro, Matsusaka, Takahiro, Morrison, Ciaran, Vagnarelli, Paola, Hoshi, Osamu, Ushiki, Tatsuo, Nojima, Kuniharu, Fukagawa, Tatsuo, Waizenegger, Irene C., Peters, Jan-Michael, Earnshaw, William C., Takeda, Shunichi
Published in Developmental cell (01.12.2001)
Published in Developmental cell (01.12.2001)
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Journal Article