Green Drug Discovery: Novel Fragment Space from the Biomass-Derived Molecule Dihydrolevoglucosenone (Cyrene TM )
Dekker, Tom, Harteveld, Jaap W, Wágner, Gábor, de Vries, Max C M, Custers, Hans, van de Stolpe, Andrea C, de Esch, Iwan J P, Wijtmans, Maikel
Published in Molecules (Basel, Switzerland) (13.02.2023)
Published in Molecules (Basel, Switzerland) (13.02.2023)
Get full text
Journal Article
Discovery and Preclinical Characterization of 3‑((4-(4-Chlorophenyl)-7-fluoroquinoline-3-yl)sulfonyl)benzonitrile, a Novel Non-acetylenic Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator for Psychiatric Indications
Galambos, János, Bielik, Attila, Krasavin, Mikhail, Orgován, Zoltán, Domány, György, Nógrádi, Katalin, Wágner, Gábor, Balogh, György T, Béni, Zoltán, Kóti, János, Szakács, Zoltán, Bobok, Amrita, Kolok, Sándor, Mikó-Bakk, Mónika L, Vastag, Mónika, Sághy, Katalin, Laszy, Judit, Halász, Attila Sándor, Balázs, Ottilia, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M
Published in Journal of medicinal chemistry (23.03.2017)
Published in Journal of medicinal chemistry (23.03.2017)
Get full text
Journal Article
4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H-3 Receptor Agonists with in Vivo Central Nervous System Activity
Wagner, Gabor, Mocking, Tamara A. M., Arimont, Marta, Provensi, Gustavo, Rani, Barbara, Silva-Marques, Bruna, Latacz, Gniewomir, Pereira, Daniel Da Costa, Karatzidou, Christina, Vischer, Henry F., Wijtmans, Maikel, Kiec-Kononowicz, Katarzyna, de Esch, Iwan J. P., Leurs, Rob
Published in Journal of medicinal chemistry (12.12.2019)
Published in Journal of medicinal chemistry (12.12.2019)
Get full text
Journal Article
4‑(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity
Wágner, Gábor, Mocking, Tamara A. M, Arimont, Marta, Provensi, Gustavo, Rani, Barbara, Silva-Marques, Bruna, Latacz, Gniewomir, Da Costa Pereira, Daniel, Karatzidou, Christina, Vischer, Henry F, Wijtmans, Maikel, Kieć-Kononowicz, Katarzyna, de Esch, Iwan J. P, Leurs, Rob
Published in Journal of medicinal chemistry (12.12.2019)
Published in Journal of medicinal chemistry (12.12.2019)
Get full text
Journal Article
SAR exploration of the non-imidazole histamine H-3 receptor ligand ZEL-H16 reveals potent inverse agonism
Wagner, Gabor, Mocking, Tamara A. M., Ma, Xiaoyuan, Slynko, Inna, Pereira, Daniel Da Costa, Breeuwer, Robin, Rood, Niek J. N., van der Horst, Cas, Vischer, Henry F., de Graaf, Chris, de Esch, Iwan J. P., Wijtmans, Maikel, Leurs, Rob
Published in Archiv der Pharmazie (Weinheim) (01.01.2023)
Published in Archiv der Pharmazie (Weinheim) (01.01.2023)
Get full text
Journal Article
Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands
Éliás, Olivér, Kovács, Zoltán, Wágner, Gábor, Némethy, Zsolt, Tarcsay, Ákos, Greiner, István
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Published in Bioorganic & medicinal chemistry letters (01.09.2016)
Get full text
Journal Article
Discovery of 4-amino-3-arylsulfoquinolines, a novel non-acetylenic chemotype of metabotropic glutamate 5 (mGlu5) receptor negative allosteric modulators
Galambos, János, Bielik, Attila, Wágner, Gábor, Domány, György, Kóti, János, Béni, Zoltán, Szigetvári, Áron, Sánta, Zsuzsanna, Orgován, Zoltán, Bobok, Amrita, Kiss, Béla, Mikó-Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Krasavin, Mikhail, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M.
Published in European journal of medicinal chemistry (16.06.2017)
Published in European journal of medicinal chemistry (16.06.2017)
Get full text
Journal Article
4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate
Galambos, János, Domány, György, Nógrádi, Katalin, Wágner, Gábor, Keserű, György M., Bobok, Amrita, Kolok, Sándor, Mikó-Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Kóti, János, Szakács, Zoltán, Béni, Zoltán, Gál, Krisztina, Szombathelyi, Zsolt, Greiner, István
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Published in Bioorganic & medicinal chemistry letters (15.02.2016)
Get full text
Journal Article
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Lead optimization
Nogradi, Katalin, Wagner, Gabor, Domany, Gyorgy, Bobok, Amrita, Magdo, Ildiko, Kolok, Sandor, Miko-Bakk, Monika L., Vastag, Monika, Saghy, Katalin, Gyertyan, Istvan, Koti, Janos, Gal, Krisztina, Farkas, Sandor, Keseru, Gyorgy M., Greiner, Istvan, Szombathelyi, Zsolt
Published in Bioorganic & medicinal chemistry letters (15.04.2015)
Published in Bioorganic & medicinal chemistry letters (15.04.2015)
Get full text
Journal Article
Covalent Inhibition of the Histamine H 3 Receptor
Wágner, Gábor, Mocking, Tamara A M, Kooistra, Albert J, Slynko, Inna, Ábrányi-Balogh, Péter, Keserű, György M, Wijtmans, Maikel, Vischer, Henry F, de Esch, Iwan J P, Leurs, Rob
Published in Molecules (Basel, Switzerland) (11.12.2019)
Published in Molecules (Basel, Switzerland) (11.12.2019)
Get full text
Journal Article
Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Hit-to-lead optimization
Nógrádi, Katalin, Wágner, Gábor, Domány, György, Bobok, Amrita, Magdó, Ildikó, Kiss, Béla, Kolok, Sándor, Fónagy, Katalin, Gyertyán, István, Háda, Viktor, Kóti, János, Gál, Krisztina, Farkas, Sándor, Keserű, György M., Greiner, István, Szombathelyi, Zsolt
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Get full text
Journal Article
Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists
Galambos, János, Wágner, Gábor, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Bakk, Mónika L., Vastag, Mónika, Sághy, Katalin, Gyertyán, István, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Get full text
Journal Article
Interaction between Nutrition and Herbicide Application in Pea Culture
Wagner, Gabor, Nadasy, Erzsebet
Published in Communications in soil science and plant analysis (01.01.2009)
Published in Communications in soil science and plant analysis (01.01.2009)
Get full text
Journal Article
Conference Proceeding
Hit-to-lead optimization of disubstituted oxadiazoles and tetrazoles as mGluR5 NAMs
Wágner, Gábor, Wéber, Csaba, Nyéki, Olga, Nógrádi, Katalin, Bielik, Attila, Molnár, László, Bobok, Amrita, Horváth, Attila, Kiss, Béla, Kolok, Sándor, Nagy, József, Kurkó, Dalma, Gál, Krisztina, Greiner, István, Szombathelyi, Zsolt, Keserű, György M., Domány, György
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Get full text
Journal Article
Distinct behavior of mutant triosephosphate isomerase in hemolysate and in isolated form: molecular basis of enzyme deficiency
Orosz, Ferenc, Oláh, Judit, Alvarez, Marco, Keserű, György M., Szabó, Beáta, Wágner, Gábor, Kovári, Zoltán, Horányi, Margit, Baróti, Klára, Martial, Joseph A., Hollán, Susan, Ovádi, Judit
Published in Blood (15.11.2001)
Published in Blood (15.11.2001)
Get full text
Journal Article
Web Resource
Tubulin and microtubule are potential targets for brain hexokinase binding
Wágner, Gábor, Kovács, János, Löw, Péter, Orosz, Ferenc, Ovádi, Judit
Published in FEBS letters (30.11.2001)
Published in FEBS letters (30.11.2001)
Get full text
Journal Article
H3 ANTAGONISTS CONTAINING PHENOXYPIPERIDINE CORE STRUCTURE
BARTANE, SZALAI, WAGNER, Gabor, KISS, Bela, BALAZS, Ottilia, NAGY, Noemi, SCHMIDT, Eva
Year of Publication 28.02.2019
Get full text
Year of Publication 28.02.2019
Patent
H3 ANTAGONISTS CONTAINING PHENOXYPIPERIDINE CORE STRUCTURE
WAGNER Gabor Andras, NAGY Noemi, BARTANE SZALAI Gizella, KISS Bela, SCHMIDT Eva, BALAZS Ottilia
Year of Publication 30.10.2018
Get full text
Year of Publication 30.10.2018
Patent