Functionally Biased D2R Antagonists: Targeting the β‑Arrestin Pathway to Improve Antipsychotic Treatment
Weïwer, Michel, Xu, Qihong, Gale, Jennifer P, Lewis, Michael, Campbell, Arthur J, Schroeder, Frederick A, Van de Bittner, Genevieve C, Walk, Michelle, Amaya, Aldo, Su, Ping, D̵ordevic, Luka, Sacher, Joshua R, Skepner, Adam, Fei, David, Dennehy, Kelly, Nguyen, Shannon, Faloon, Patrick W, Perez, Jose, Cottrell, Jeffrey R, Liu, Fang, Palmer, Michelle, Pan, Jen Q, Hooker, Jacob M, Zhang, Yan-Ling, Scolnick, Edward, Wagner, Florence F, Holson, Edward B
Published in ACS chemical biology (20.04.2018)
Published in ACS chemical biology (20.04.2018)
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The Use of Informer Sets in Screening: Perspectives on an Efficient Strategy to Identify New Probes
Clemons, Paul A., Bittker, Joshua A., Wagner, Florence F., Hands, Allison, Dančík, Vlado, Schreiber, Stuart L., Choudhary, Amit, Wagner, Bridget K.
Published in SLAS discovery (01.08.2021)
Published in SLAS discovery (01.08.2021)
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Selective HDAC1/HDAC2 Inhibitors Induce Neuroblastoma Differentiation
Frumm, Stacey M., Fan, Zi Peng, Ross, Kenneth N., Duvall, Jeremy R., Gupta, Supriya, VerPlank, Lynn, Suh, Byung-Chul, Holson, Edward, Wagner, Florence F., Smith, William B., Paranal, Ronald M., Bassil, Christopher F., Qi, Jun, Roti, Giovanni, Kung, Andrew L., Bradner, James E., Tolliday, Nicola, Stegmaier, Kimberly
Published in Chemistry & biology (23.05.2013)
Published in Chemistry & biology (23.05.2013)
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Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T‑Type Calcium Channel Modulators
Zhang, Yan-Ling, Moran, Sean P., Allen, Andrew, Baez-Nieto, David, Xu, Qihong, Wang, Lei A., Martenis, William E., Sacher, Joshua R., Gale, Jennifer P., Weïwer, Michel, Wagner, Florence F., Pan, Jen Q.
Published in ACS pharmacology & translational science (11.03.2022)
Published in ACS pharmacology & translational science (11.03.2022)
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Inhibition of Histone Deacetylases 1, 2, and 3 Enhances Clearance of Cholesterol Accumulation in Niemann-Pick C1 Fibroblasts
Cruz, Dana L., Pipalia, Nina, Mao, Shu, Gadi, Deepti, Liu, Gang, Grigalunas, Michael, O’Neill, Matthew, Quinn, Taylor R., Kipper, Andi, Ekebergh, Andreas, Dimmling, Alexander, Gartner, Carlos, Melancon, Bruce J., Wagner, Florence F., Holson, Edward, Helquist, Paul, Wiest, Olaf, Maxfield, Frederick R.
Published in ACS pharmacology & translational science (11.06.2021)
Published in ACS pharmacology & translational science (11.06.2021)
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Hydroxamate-Based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress via a Histone Deacetylase-Independent Catalase-Like Mechanism
Olson, David E., Sleiman, Sama F., Bourassa, Megan W., Wagner, Florence F., Gale, Jennifer P., Zhang, Yan-Ling, Ratan, Rajiv R., Holson, Edward B.
Published in Chemistry & biology (23.04.2015)
Published in Chemistry & biology (23.04.2015)
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Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis
Chou, Danny Hung-Chieh, Holson, Edward B., Wagner, Florence F., Tang, Alicia J., Maglathlin, Rebecca L., Lewis, Timothy A., Schreiber, Stuart L., Wagner, Bridget K.
Published in Chemistry & biology (22.06.2012)
Published in Chemistry & biology (22.06.2012)
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Translation of HDAC6 PET Imaging Using [18F]EKZ-001–cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates
Celen, Sofie, Rokka, Johanna, Gilbert, Tonya M, Koole, Michel, Vermeulen, Isabeau, Serdons, Kim, Schroeder, Frederick A, Wagner, Florence F, Bleeser, Tom, Hightower, Baileigh G, Hu, Jiyun, Rahal, Dania, Beyzavi, Hudson, Vanduffel, Wim, Van Laere, Koen, Kranz, Janice E, Hooker, Jacob M, Bormans, Guy, Cawthorne, Christopher J
Published in ACS chemical neuroscience (01.04.2020)
Published in ACS chemical neuroscience (01.04.2020)
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FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors
Schroeder, Frederick A., Chonde, Daniel B., Riley, Misha M., Moseley, Christian K., Granda, Michael L., Wilson, Colin M., Wagner, Florence F., Zhang, Yan-Ling, Gale, Jennifer, Holson, Edward B., Haggarty, Stephen J., Hooker, Jacob M.
Published in Neuroscience letters (29.08.2013)
Published in Neuroscience letters (29.08.2013)
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Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain
Wang, Changning, Eessalu, Thomas E, Barth, Vanessa N, Mitch, Charles H, Wagner, Florence F, Hong, Yijia, Neelamegam, Ramesh, Schroeder, Frederick A, Holson, Edward B, Haggarty, Stephen J, Hooker, Jacob M
Published in American journal of nuclear medicine and molecular imaging (2013)
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Published in American journal of nuclear medicine and molecular imaging (2013)
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Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Liang, Steven H., Chen, Jinshan Michael, Normandin, Marc D., Chang, Jeanne S., Chang, George C., Taylor, Christine K., Trapa, Patrick, Plummer, Mark S., Para, Kimberly S., Conn, Edward L., Lopresti-Morrow, Lori, Lanyon, Lorraine F., Cook, James M., Richter, Karl E. G., Nolan, Charlie E., Schachter, Joel B., Janat, Fouad, Che, Ye, Shanmugasundaram, Veerabahu, Lefker, Bruce A., Enerson, Bradley E., Livni, Elijahu, Wang, Lu, Guehl, Nicolas J., Patnaik, Debasis, Wagner, Florence F., Perlis, Roy, Holson, Edward B., Haggarty, Stephen J., El Fakhri, Georges, Kurumbail, Ravi G., Vasdev, Neil
Published in Angewandte Chemie (08.08.2016)
Published in Angewandte Chemie (08.08.2016)
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Functional Interpretation of Single Amino Acid Substitutions in 1,330 Disease-Associated Genes
Iqbal, Sumaiya, Berg Jespersen, Jakob, Perez-Palma, Eduardo, May, Patrick, Palotie, Aarno, Cottrell, Jeffrey R., Wagner, Florence F., Daly, Mark J., Campbell, Arthur J., Lal, Dennis
Published in Biophysical journal (15.02.2019)
Published in Biophysical journal (15.02.2019)
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Journal Article
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests
Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L
Published in PloS one (14.08.2013)
Published in PloS one (14.08.2013)
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Identification and Characterization of Variant Intolerant Sites across Human Protein 3-Dimensional Structures
Iqbal, Sumaiya, Berg Jespersen, Jakob, Perez-Palma, Eduardo, May, Patrick, Heyne, Henrike, Lage, Kasper, Steensbjerre Møller, Rikke, Wagner, Florence F., Daly, Mark, Campbell, Arthur J., Lal, Dennis
Published in Biophysical journal (02.02.2018)
Published in Biophysical journal (02.02.2018)
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Glycogen synthase kinase 3-[beta] inhibition induces lymphangiogenesis through [beta]-catenin-dependent and mTOR-independent pathways
Stump, Benjamin, Shrestha, Shikshya, Lamattina, Anthony M, Louis, Pierce H, Cho, Woohyun, Perrella, Mark A, Ai, Xingbin, Rosas, Ivan O, Wagner, Florence F, Priolo, Carmen, Astin, Jonathan, El-Chemaly, Souheil
Published in PloS one (09.04.2019)
Published in PloS one (09.04.2019)
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Regioselective 5-, 4-, and 2-Substitution of (S)-6-Chloronicotine and 4-Substitution of (S)-5-Chloronicotine
Wagner, Florence F., Comins, Daniel L.
Published in European Journal of Organic Chemistry (01.08.2006)
Published in European Journal of Organic Chemistry (01.08.2006)
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