Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery
Huchet, Quentin A, Kuhn, Bernd, Wagner, Björn, Kratochwil, Nicole A, Fischer, Holger, Kansy, Manfred, Zimmerli, Daniel, Carreira, Erick M, Müller, Klaus
Published in Journal of medicinal chemistry (25.11.2015)
Published in Journal of medicinal chemistry (25.11.2015)
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Elevated high-sensitivity cardiac troponin T serum concentration in subjects with spinal cord injury
Wagner, Björn, Weidner, Norbert, Hug, Andreas
Published in International journal of cardiology (15.11.2023)
Published in International journal of cardiology (15.11.2023)
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A novel application of hydrophilic interaction liquid chromatography for the identification of compounds with intramolecular hydrogen bonds
Pugliano, Alessandra, Kuhn, Bernd, Manevski, Nenad, Wagner, Björn, Wittwer, Matthias Beat
Published in Journal of pharmaceutical and biomedical analysis (01.01.2025)
Published in Journal of pharmaceutical and biomedical analysis (01.01.2025)
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Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein
Fischer, Holger, Ullah, Mohammed, de la Cruz, Cecile C, Hunsaker, Thomas, Senn, Claudia, Wirz, Thomas, Wagner, Björn, Draganov, Dragomir, Vazvaei, Faye, Donzelli, Massimiliano, Paehler, Axel, Merchant, Mark, Yu, Li
Published in Neuro-oncology (Charlottesville, Va.) (09.06.2020)
Published in Neuro-oncology (Charlottesville, Va.) (09.06.2020)
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On the polarity of partially fluorinated methyl groups
Huchet, Quentin A., Kuhn, Bernd, Wagner, Björn, Fischer, Holger, Kansy, Manfred, Zimmerli, Daniel, Carreira, Erick M., Müller, Klaus
Published in Journal of fluorine chemistry (01.08.2013)
Published in Journal of fluorine chemistry (01.08.2013)
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Journal Article
Partially fluorinated alkoxy groups − Conformational adaptors to changing environments
Huchet, Quentin A., Trapp, Nils, Kuhn, Bernd, Wagner, Björn, Fischer, Holger, Kratochwil, Nicole A., Carreira, Erick M., Müller, Klaus
Published in Journal of fluorine chemistry (01.06.2017)
Published in Journal of fluorine chemistry (01.06.2017)
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Journal Article
Oxetanes as Promising Modules in Drug Discovery
Wuitschik, Georg, Rogers-Evans, Mark, Müller, Klaus, Fischer, Holger, Wagner, Björn, Schuler, Franz, Polonchuk, Liudmila, Carreira, Erick M.
Published in Angewandte Chemie International Edition (27.11.2006)
Published in Angewandte Chemie International Edition (27.11.2006)
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Journal Article
Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties
Vorberg, Raffael, Trapp, Nils, Zimmerli, Daniel, Wagner, Björn, Fischer, Holger, Kratochwil, Nicole A., Kansy, Manfred, Carreira, Erick M., Müller, Klaus
Published in ChemMedChem (06.10.2016)
Published in ChemMedChem (06.10.2016)
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The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II
Glöckner, Steffen, Ngo, Khang, Wagner, Björn, Heine, Andreas, Klebe, Gerhard
Published in Biomolecules (Basel, Switzerland) (27.03.2020)
Published in Biomolecules (Basel, Switzerland) (27.03.2020)
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Journal Article
Sugar Acetonides are a Superior Motif for Addressing the Large, Solvent‐Exposed Ribose‐33 Pocket of tRNA‐Guanine Transglycosylase
Movsisyan, Levon D., Schäfer, Elisabeth, Nguyen, Andreas, Ehrmann, Frederik R., Schwab, Anatol, Rossolini, Thomas, Zimmerli, Daniel, Wagner, Björn, Daff, Hamina, Heine, Andreas, Klebe, Gerhard, Diederich, François
Published in Chemistry : a European journal (11.07.2018)
Published in Chemistry : a European journal (11.07.2018)
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Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β‐Position to the Amino Group
Schnider, Patrick, Dolente, Cosimo, Stalder, Henri, Martin, Rainer E., Reinmüller, Viktoria, Marty, Roman, Wyss Gramberg, Caroline, Wagner, Björn, Fischer, Holger, Alker, André M., Müller, Klaus
Published in Chembiochem : a European journal of chemical biology (15.01.2020)
Published in Chembiochem : a European journal of chemical biology (15.01.2020)
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Journal Article
Kinetics of lipid bilayer permeation of a series of ionisable drugs and their correlation with human transporter-independent intestinal permeability
Hermann, Katharina F., Neuhaus, Claudia S., Micallef, Virgine, Wagner, Björn, Hatibovic, Maja, Aschmann, Hélène E., Paech, Franziska, Alvarez-Sanchez, Rubén, Krämer, Stefanie D., Belli, Sara
Published in European journal of pharmaceutical sciences (15.06.2017)
Published in European journal of pharmaceutical sciences (15.06.2017)
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Journal Article
Characterization of multilayer structures in fiber reinforced polymer employing synchrotron and laboratory X-ray CT
Wirjadi, Oliver, Godehardt, Michael, Schladitz, Katja, Wagner, Björn, Rack, Alexander, Gurka, Martin, Nissle, Sebastian, Noll, Andreas
Published in International journal of materials research (14.07.2014)
Published in International journal of materials research (14.07.2014)
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Journal Article
From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters
Barandun, Luzi Jakob, Immekus, Florian, Kohler, Philipp C., Tonazzi, Sandro, Wagner, Björn, Wendelspiess, Severin, Ritschel, Tina, Heine, Andreas, Kansy, Manfred, Klebe, Gerhard, Diederich, François
Published in Chemistry : a European journal (23.07.2012)
Published in Chemistry : a European journal (23.07.2012)
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Journal Article
PAMPA-excipient classification gradient map
BENDELS, Stefanie, TSINMAN, Oksana, WAGNER, Björn, LIPP, Dana, PARRILLA, Isabelle, KANSY, Manfred, AVDEEF, Alex
Published in Pharmaceutical research (01.11.2006)
Published in Pharmaceutical research (01.11.2006)
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Journal Article
Oxetanes in Drug Discovery: Structural and Synthetic Insights
Wuitschik, Georg, Carreira, Erick M, Wagner, Björn, Fischer, Holger, Parrilla, Isabelle, Schuler, Franz, Rogers-Evans, Mark, Müller, Klaus
Published in Journal of medicinal chemistry (22.04.2010)
Published in Journal of medicinal chemistry (22.04.2010)
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Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?
Ngo, Khang, Collins-Kautz, Chelsey, Gerstenecker, Stefan, Wagner, Björn, Heine, Andreas, Klebe, Gerhard
Published in Journal of medicinal chemistry (26.03.2020)
Published in Journal of medicinal chemistry (26.03.2020)
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Journal Article
Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors
Schweizer, Eliane, Hoffmann-Roeder, Anja, Olsen, Jacob A., Seiler, Paul, Obst-Sander, Ulrike, Wagner, Bjorn, Kansy, Manfred, Banner, David W., Diederich, Francois
Published in Organic & biomolecular chemistry (01.01.2006)
Published in Organic & biomolecular chemistry (01.01.2006)
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