Development of a Catalytic Enantioselective Conjugate Addition of 1,3-Dicarbonyl Compounds to Nitroalkenes for the Synthesis of Endothelin-A Antagonist ABT-546. Scope, Mechanism, and Further Application to the Synthesis of the Antidepressant Rolipram
Barnes, David M, Ji, Jianguo, Fickes, Michael G, Fitzgerald, Michael A, King, Steven A, Morton, Howard E, Plagge, Frederick A, Preskill, Margo, Wagaw, Seble H, Wittenberger, Steven J, Zhang, Ji
Published in Journal of the American Chemical Society (06.11.2002)
Published in Journal of the American Chemical Society (06.11.2002)
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Validation of Diacyl Glycerolacyltransferase I as a Novel Target for the Treatment of Obesity and Dyslipidemia Using a Potent and Selective Small Molecule Inhibitor
Zhao, Gang, Souers, Andrew J, Voorbach, Martin, Falls, H. Doug, Droz, Brian, Brodjian, Sevan, Lau, Yau Yi, Iyengar, Rajesh R, Gao, Ju, Judd, Andrew S, Wagaw, Seble H, Ravn, Matthew M, Engstrom, Kenneth M, Lynch, John K, Mulhern, Mathew M, Freeman, Jennifer, Dayton, Brian D, Wang, Xiaojun, Grihalde, Nelson, Fry, Dennis, Beno, David W. A, Marsh, Kennan C, Su, Zhi, Diaz, Gilbert J, Collins, Christine A, Sham, Hing, Reilly, Regina M, Brune, Michael E, Kym, Philip R
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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Development of a Scalable Synthesis of Dipeptidyl Peptidase-4 Inhibitor ABT-279
McDermott, Todd S, Bhagavatula, Lakshmi, Borchardt, Thomas B, Engstrom, Kenneth M, Gandarilla, Jorge, Kotecki, Brian J, Kruger, Albert W, Rozema, Michael J, Sheikh, Ahmad Y, Wagaw, Seble H, Wittenberger, Steven J
Published in Organic process research & development (20.11.2009)
Published in Organic process research & development (20.11.2009)
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Process Development of a Diacyl Glycerolacyltransferase-1 Inhibitor
Ravn, Matthew M, Wagaw, Seble H, Engstrom, Kenneth M, Mei, Jianzhang, Kotecki, Brian, Souers, Andrew J, Kym, Philip R, Judd, Andrew S, Zhao, Gang
Published in Organic process research & development (19.03.2010)
Published in Organic process research & development (19.03.2010)
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Screening for Cardiovascular Safety: A Structure−Activity Approach for Guiding Lead Selection of Melanin Concentrating Hormone Receptor 1 Antagonists
Kym, Philip R, Souers, Andrew J, Campbell, Thomas J, Lynch, John K, Judd, Andrew S, Iyengar, Rajesh, Vasudevan, Anil, Gao, Ju, Freeman, Jennifer C, Wodka, Dariusz, Mulhern, Mathew, Zhao, Gang, Wagaw, Seble H, Napier, James J, Brodjian, Sevan, Dayton, Brian D, Reilly, Regina M, Segreti, Jason A, Fryer, Ryan M, Preusser, Lee C, Reinhart, Glenn A, Hernandez, Lisa, Marsh, Kennan C, Sham, Hing L, Collins, Christine A, Polakowski, James S
Published in Journal of medicinal chemistry (06.04.2006)
Published in Journal of medicinal chemistry (06.04.2006)
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Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists
Vasudevan, Anil, Souers, Andrew J., Freeman, Jennifer C., Verzal, Mary K., Gao, Ju, Mulhern, Mathew M., Wodka, Derek, Lynch, John K., Engstrom, Kenneth M., Wagaw, Seble H., Brodjian, Sevan, Dayton, Brian, Falls, Doug H., Bush, Eugene, Brune, Michael, Shapiro, Robin D., Marsh, Kennan C., Hernandez, Lisa E., Collins, Christine A., Kym, Philip R.
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
SHANLEY JASON P, LIU DONG, GAI YONGHUA, SUN YING, GRIEME TIM, GRAMPOVNIK DAVID J, KU YIYIN, OR YAT SUN, ENGSTROM KEN, MCDANIEL KEITH F, WAGAW SEBLE H, KEMPF DALE J, CHEN HUI JU
Year of Publication 09.05.2014
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Year of Publication 09.05.2014
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ANTI-VIRAL COMPOUNDS TO TREAT HCV INFECTION
HUTCHINS CHARLES W, WOLLER KEVIN R, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, FLENTGE CHARLES A, PATEL SACHIN V, JINKERSON TAMMIE K, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, CALIFANO JEAN C, CASPI DANIEL D, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, RANDOLPH JOHN T, TUFANO MICHAEL D, KRUEGER ALLAN C, MOTTER CHRISTOPHER E, LIU DACHUN, WAGAW SEBLE H, LI WENKE, BELLIZZI MARY E
Year of Publication 27.03.2014
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Year of Publication 27.03.2014
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MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
SHANLEY JASON P, LIU DONG, GAI YONGHUA, SUN YING, GRIEME TIM, GRAMPOVNIK DAVID J, KU YIYIN, OR YAT SUN, ENGSTROM KEN, MC DANIEL KEITH F, WAGAW SEBLE H, KEMPF DALE J, CHEN HUI JU
Year of Publication 07.05.2012
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Year of Publication 07.05.2012
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ANTI-VIRAL COMPOUNDS TO TREAT HCV INFECTION
HUTCHINS CHARLES W, WOLLER KEVIN R, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, FLENTGE CHARLES A, PATEL SACHIN V, JINKERSON TAMMIE K, SARRIS KATHY, GAO YI, DEGOEY DAVID A, KATI WARREN M, KEDDY RYAN G, MATULENKO MARK A, CALIFANO JEAN C, CASPI DANIEL D, MARING CLARENCE J, DONNER PAMELA L, PRATT JOHN K, NELSON LISSA T, WAGNER ROLF, RANDOLPH JOHN T, TUFANO MICHAEL D, KRUEGER ALLAN C, MOTTER CHRISTOPHER E, LIU DACHUN, WAGAW SEBLE H, LI WENKE, BELLIZZI MARY E
Year of Publication 24.10.2012
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Year of Publication 24.10.2012
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MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS
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Year of Publication 19.03.2010
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Year of Publication 19.03.2010
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Sarris, Kathy, Wagaw, Seble H, Hutchins, Charles W, Carroll, William A, Li, Wenke, Randolph, John T, Jinkerson, Tammie K, Patel, Sachin V, Califano, Jean-Christophe C, Krueger, Allan C, Matulenko, Mark A, Betebenner, David A, Liu, Dachun, Tufano, Michael D, Kati, Warren M, Keddy, Ryan G, Flentge, Charles A, Maring, Clarence J, Bellizzi, Mary E, Pratt, John K, Hutchinson, Douglas K, Wagner, Rolf, Caspi, Daniel D, Rockway, Todd W, Donner, Pamela L, DeGoey, David A, Motter, Christopher E, Gao, Yi, Woller, Kevin R, Nelson, Lissa T
Year of Publication 14.09.2023
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Year of Publication 14.09.2023
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HETEROCYCLIC COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS (HCV)
PATEL, SACHIN V, KEDDY, RYAN G, HUTCHINS, CHARLES W, LIU, DACHUN, DONNER, PAMELA L, RANDOLPH, JOHN T, ROCKWAY, TODD W, TUFANO, MICHAEL D, KATI, WARREN M, YI GAO, HUTCHINSON, DOUGLAS K, KRUEGER, ALLAN C, FLENTGE, CHARLES A, BETEBENNER, DAVID A, BELLIZZI, MARY E, JINKERSON, TAMMIE K, SARRIS, KATHY, MARING, CLARENCE J, WAGAW, SEBLE H, LI, WENKE, DEGOEY, DAVID A, WAGNER, ROLF, CALIFANO, JEAN C, CASPI, DANIEL D, WOLLER, KEVIN R, PRATT, JOHN K, NELSON, LISSA T, MOTTER, CHRISTOPHER E, MATULENKO, MARK A
Year of Publication 31.07.2021
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Year of Publication 31.07.2021
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HUTCHINS CHARLES W, WOLLER KEVIN R, BETEBENNER DAVID A, HUTCHINSON DOUGLAS K, ROCKWAY TODD W, FLENTGE CHARLES A, PATEL SACHIN V, SARRIS KATHY, JINKERSON TAMMIE K, GAO YI, DEGOEY DAVID A, KEDDY RYAN G, KATI WARREN M, MATULENKO MARK A, CALIFANO JEAN C, CASPI DANIEL D, MARING CLARENCE J, PRATT JOHN K, DONNER PAMELA L, NELSON LISSA T, WAGNER ROLF, RANDOLPH JOHN T, CARROLL WILLIAM A, TUFANO MICHAEL D, KRUEGER ALLAN C, MOTTER CHRISTOPHER E, LIU DACHUN, LI WENKE, WAGAW SEBLE H, BELLIZZI MARY E
Year of Publication 26.05.2021
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Year of Publication 26.05.2021
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ANTI-VIRAL COMPOUNDS
WAGAW, Seble H, CALIFANO, Jean C, WOLLER, Kevin R, CASPI, Daniel D, JINKERSON, Tammie K, SARRIS, Kathy, KRUEGER, Allan C, MATULENKO, Mark A, NELSON, Lissa T, BETEBENNER, David A, MARING, Clarence J, LI, Wenke, MOTTER, Christopher E, GAO, Yi, HUTCHINS, Charles W, KEDDY, Ryan G, PRATT, John K, PATEL, Sachin V, DEGOEY, David A, LIU, Dachun, DONNER, Pamela L, RANDOLPH, John T, WAGNER, Rolf, ROCKWAY, Todd W, HUTCHINSON, Douglas K, BELLIZZI, Mary E, CARROLL, William A, KATI, Warren M, FLENTGE, Charles A, TUFANO, Michael D
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Year of Publication 27.01.2021
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Year of Publication 03.12.2020
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Year of Publication 03.12.2020
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PROCESS FOR PREPARING METHYL{(2S,3R)-1-[(2S)-2-{5-[(2R,5R)-1-{3,5-DIFLUORO-4-[4-(4-FLUOROPHENYL)PIPERIDINE-1-YL]PHENYL}-5-(6-FLUORO-2-{(2S)-1-[N-(METHOXYCARBONYL)-O-METHYL-L-THREONYL]PYRROLIDINE-2-YL}-1H-BENZIMIDAZOLE-5-YL)pyrrolidinePYRROLIDINE-2-YL]-6-FLUORO-1H-BENZIMIDAZOLE-2-YL}PYRROLIDINE-1-YL]-3-METHOXY-1-OXOBUTANE-2-YL}CARBAMATE
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Year of Publication 30.09.2019
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Year of Publication 30.09.2019
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ZHANG GEOFF G, BRACKEMEYER PAUL J, DIWAN MOIZ, WAGAW SEBLE H, PAL AGNES E, SHEIKH AHMAD Y, GONG YUCHUAN
Year of Publication 25.06.2015
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Year of Publication 25.06.2015
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