Structure–activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350
Raboisson, Pierre, de Kock, Herman, Rosenquist, Åsa, Nilsson, Magnus, Salvador-Oden, Lourdes, Lin, Tse-I, Roue, Natalie, Ivanov, Vladimir, Wähling, Horst, Wickström, Kristina, Hamelink, Elizabeth, Edlund, Michael, Vrang, Lotta, Vendeville, Sandrine, Van de Vreken, Wim, McGowan, David, Tahri, Abdellah, Hu, Lili, Boutton, Carlo, Lenz, Oliver, Delouvroy, Frederic, Pille, Geert, Surleraux, Dominique, Wigerinck, Piet, Samuelsson, Bertil, Simmen, Kenneth
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: Use of cyclopentane and cyclopentene P2-motifs
Bäck, Marcus, Johansson, Per-Ola, Wångsell, Fredrik, Thorstensson, Fredrik, Kvarnström, Ingemar, Ayesa, Susana, Wähling, Horst, Pelcman, Mikael, Jansson, Katarina, Lindström, Stefan, Wallberg, Hans, Classon, Björn, Rydergård, Christina, Vrang, Lotta, Hamelink, Elizabeth, Hallberg, Anders, Rosenquist, Åsa, Samuelsson, Bertil
Published in Bioorganic & medicinal chemistry (15.11.2007)
Published in Bioorganic & medicinal chemistry (15.11.2007)
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Synthesis and SAR of potent inhibitors of the Hepatitis C virus NS3/4A protease: Exploration of P2 quinazoline substituents
Nilsson, Magnus, Belfrage, Anna Karin, Lindström, Stefan, Wähling, Horst, Lindquist, Charlotta, Ayesa, Susana, Kahnberg, Pia, Pelcman, Mikael, Benkestock, Kurt, Agback, Tatiana, Vrang, Lotta, Terelius, Ylva, Wikström, Kristina, Hamelink, Elizabeth, Rydergård, Christina, Edlund, Michael, Eneroth, Anders, Raboisson, Pierre, Lin, Tse-I, de Kock, Herman, Wigerinck, Piet, Simmen, Kenneth, Samuelsson, Bertil, Rosenquist, Åsa
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
Published in Bioorganic & medicinal chemistry letters (15.07.2010)
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Year of Publication 02.06.2011
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Year of Publication 02.06.2011
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Year of Publication 15.09.2011
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Year of Publication 15.09.2011
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Year of Publication 20.01.2016
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Year of Publication 20.01.2016
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