Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
Oballa, Renata M, Belair, Liette, Black, W. Cameron, Bleasby, Kelly, Chan, Chi Chung, Desroches, Carole, Du, Xiaobing, Gordon, Robert, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J, Hamelin, Emelie, Huang, Zheng, Kennedy, Brian, Lachance, Nicolas, Landry, France, Li, Chun Sing, Mancini, Joseph, Normandin, Denis, Pocai, Alessandro, Powell, David A, Ramtohul, Yeeman K, Skorey, Kathryn, Sørensen, Dan, Sturkenboom, Wayne, Styhler, Angela, Waddleton, Deena M, Wang, Hao, Wong, Simon, Xu, Lijing, Zhang, Lei
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets
Waddleton, Deena, Wu, Weizhen, Feng, Yue, Thompson, Chris, Wu, Michael, Zhou, Yun-Ping, Howard, Andrew, Thornberry, Nancy, Li, Jing, Mancini, Joseph A.
Published in Biochemical pharmacology (01.10.2008)
Published in Biochemical pharmacology (01.10.2008)
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The development of potent non-peptidic PTP-1B inhibitors
DUFRESNE, Claude, ROY, Patrick, WADDLETON, Deena, RAMACHANDRAN, Chidambaram, KENNEDY, Brian P, LIJING XU, GORDON, Robert, CHI CHUNG CHAN, LEBLANC, Yves, ZHAOYIN WANG, ASANTE-APPIAH, Ernest, CROMLISH, Wanda, BOIE, Yves, FORGHANI, Farnaz, DESMARAIS, Sylvie, QINGPING WANG, SKOREY, Kathryn
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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A vertebrate slow skeletal muscle actin isoform
Mudalige, Wasana A. K. A., Jackman, Donna M., Waddleton, Deena M., Heeley, David H.
Published in The FEBS journal (01.07.2007)
Published in The FEBS journal (01.07.2007)
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Characterisation of troponin-T from salmonid fish
Waddleton, D M, Jackman, D M, Bieger, T, Heeley, D H
Published in Journal of muscle research and cell motility (01.04.1999)
Published in Journal of muscle research and cell motility (01.04.1999)
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The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B
Scapin, Giovanna, Patel, Sangita B, Becker, Joseph W, Wang, Qingping, Desponts, Caroline, Waddleton, Deena, Skorey, Kathryn, Cromlish, Wanda, Bayly, Christopher, Therien, Michel, Gauthier, Jacques Yves, Li, Chun Sing, Lau, Cheuk K, Ramachandran, Chidambaram, Kennedy, Brian P, Asante-Appiah, Ernest
Published in Biochemistry (Easton) (07.10.2003)
Published in Biochemistry (Easton) (07.10.2003)
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Heterogeneity of Atlantic salmon troponin-I
Jackman, Donna M, Pham, Tram, Noel, Jason J, Waddleton, Deena M, Dhoot, Gurtej K, Heeley, David H
Published in Biochimica et biophysica acta (08.09.1998)
Published in Biochimica et biophysica acta (08.09.1998)
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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors
LOU, Cheuk K, BAYLY, Christopher I, QINGPING WANG, SKOREY, Kathryn, WADDLETON, Deena, PAYETTE, Paul, RAMACHANDRAN, Chidambaram, KENNEDY, Brian P, SCAPIN, Giovana, GAUTHIER, Jacques Yves, CHUN SING LI, THERIEN, Michel, ASANTE-APPIAH, Ernest, CROMLISH, Wanda, BOIE, Yves, FORGHANI, Farnaz, DESMARAIS, Sylvie
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
Published in Bioorganic & medicinal chemistry letters (23.02.2004)
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Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes
Skorey, Kathryn, Waddleton, Deena, Therien, Michel, Leriche, Tammy
Published in Analytical biochemistry (01.02.2006)
Published in Analytical biochemistry (01.02.2006)
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Structure of Protein Tyrosine Phosphatase 1B in Complex with Inhibitors Bearing Two Phosphotyrosine Mimetics
Jia, Zongchao, Ye, Qilu, Dinaut, A. Nicole, Wang, Qingping, Waddleton, Deena, Payette, Paul, Ramachandran, Chidambaram, Kennedy, Brian, Hum, Gabriel, Taylor, Scott D
Published in Journal of medicinal chemistry (20.12.2001)
Published in Journal of medicinal chemistry (20.12.2001)
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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme
THERIEN, Michel, SKOREY, Kathryn, ZAMBONI, Robert, CHUN SING LI, LAU, Cheuk K, LERICHE, Tammy, VOUY LINH TRUONG, WADDLETON, Deena, RAMACHANDRAN, Chidambaram
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Characterisation of Fast, Slow and Cardiac Muscle Tropomyosins from Salmonid Fish
Heeley, David H., Bieger, Thorben, Waddleton, Deena M., Hong, Caroline, Jackman, Donna M., Mcgowan, Colin, Davidson, William S., Beavis, Ronald C.
Published in European journal of biochemistry (15.08.1995)
Published in European journal of biochemistry (15.08.1995)
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