Use of ribaxamase (SYN-004), a β-lactamase, to prevent Clostridium difficile infection in β-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial
Kokai-Kun, John F, Roberts, Tracey, Coughlin, Olivia, Le, Chenxiong, Whalen, Heidi, Stevenson, Ralph, Wacher, Vincent J, Sliman, Joseph
Published in The Lancet infectious diseases (01.05.2019)
Published in The Lancet infectious diseases (01.05.2019)
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Journal Article
Pharmacokinetics of itraconazole after intravenous and oral dosing of itraconazole‐cyclodextrin formulations
Buchanan, Charles M., Buchanan, Norma L., Edgar, Kevin J., Klein, Sandra, Little, James L., Ramsey, Michael G., Ruble, Karen M., Wacher, Vincent J., Wempe, Michael F.
Published in Journal of pharmaceutical sciences (01.11.2007)
Published in Journal of pharmaceutical sciences (01.11.2007)
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Journal Article
Active secretion and enterocytic drug metabolism barriers to drug absorption
Wacher, Vincent J., Salphati, Laurent, Benet, Leslie Z.
Published in Advanced drug delivery reviews (12.07.1996)
Published in Advanced drug delivery reviews (12.07.1996)
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Journal Article
Efficacy and safety of oral methazolamide in patients with type 2 diabetes: a 24-week, placebo-controlled, double-blind study
Simpson, Richard W, Nicholson, Geoffrey C, Proietto, Joseph, Sarah, Alana, Sanders, Kerrie M, Phillips, Gabrielle, Chambers, Jo, MacGinley, Rob, Orford, Neil, Walder, Ken, Krippner, Guy, Skoff, Kathy, Wacher, Vincent J
Published in Diabetes care (01.11.2014)
Published in Diabetes care (01.11.2014)
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Journal Article
Active secretion and enterocytic drug metabolism barriers to drug absorption
Wacher, Vincent J, Salphati, Laurent, Benet, Leslie Z
Published in Advanced drug delivery reviews (01.03.2001)
Published in Advanced drug delivery reviews (01.03.2001)
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Journal Article
Inhibiting efflux with novel non-ionic surfactants: Rational design based on vitamin E TPGS
Wempe, Michael F., Wright, Charles, Little, James L., Lightner, Janet W., Large, Shannon E., Caflisch, George B., Buchanan, Charles M., Rice, Peter J., Wacher, Vincent J., Ruble, Karen M., Edgar, Kevin J.
Published in International journal of pharmaceutics (31.03.2009)
Published in International journal of pharmaceutics (31.03.2009)
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Journal Article
Pharmacokinetics of raloxifene in male Wistar–Hannover rats: Influence of complexation with hydroxybutenyl-beta-cyclodextrin
Wempe, Michael F., Wacher, Vincent J., Ruble, Karen M., Ramsey, Michael G., Edgar, Kevin J., Buchanan, Norma L., Buchanan, Charles M.
Published in International journal of pharmaceutics (04.01.2008)
Published in International journal of pharmaceutics (04.01.2008)
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Journal Article
Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery
Benet, Leslie Z, Izumi, Takashi, Zhang, Yuanchao, Silverman, Jeffrey A, Wacher, Vincent J
Published in Journal of controlled release (01.11.1999)
Published in Journal of controlled release (01.11.1999)
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Journal Article
Conference Proceeding
Role of P-Glycoprotein and Cytochrome P450 3A in Limiting Oral Absorption of Peptides and Peptidomimetics
Wacher, Vincent J., Silverman, Jeffrey A., Zhang, Yuanchao, Benet, Leslie Z.
Published in Journal of pharmaceutical sciences (01.11.1998)
Published in Journal of pharmaceutical sciences (01.11.1998)
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Journal Article
Conference Proceeding
Pharmacokinetics of Saquinavir After Intravenous and Oral Dosing of Saquinavir: Hydroxybutenyl-β-Cyclodextrin Formulations
Buchanan, Charles M, Buchanan, Norma L, Edgar, Kevin J, Little, James L, Ramsey, Michael G, Ruble, Karen M, Wacher, Vincent J, Wempe, Michael F
Published in Biomacromolecules (01.01.2008)
Published in Biomacromolecules (01.01.2008)
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Journal Article
Grapefruit juice activates P-glycoprotein-mediated drug transport
SOLDNER, A, CHRISTIANS, U, SUSANTO, M, WACHER, V. J, SILVERMAN, J. A, BENET, L. Z
Published in Pharmaceutical research (01.04.1999)
Published in Pharmaceutical research (01.04.1999)
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Journal Article
Pharmacokinetics of Tamoxifen after Intravenous and Oral Dosing of Tamoxifen–Hydroxybutenyl-β-Cyclodextrin Formulations
Buchanan, Charles M., Buchanan, Norma L., Edgar, Kevin J., Little, James L., Malcolm, Michael O., Ruble, Karen M., Wacher, Vincent J., Wempe, Michael F.
Published in Journal of pharmaceutical sciences (01.03.2007)
Published in Journal of pharmaceutical sciences (01.03.2007)
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Journal Article
The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine
Gomez, D Y, Wacher, V J, Tomlanovich, S J, Hebert, M F, Benet, L Z
Published in Clinical pharmacology and therapeutics (01.07.1995)
Published in Clinical pharmacology and therapeutics (01.07.1995)
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Journal Article
Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery
Benet, Leslie Z., Wu, Chi-Yuan, Hebert, Mary F., Wacher, Vincent J.
Published in Journal of controlled release (01.05.1996)
Published in Journal of controlled release (01.05.1996)
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Journal Article
Conference Proceeding
Peppermint Oil Enhances Cyclosporine Oral Bioavailability in Rats: Comparison with d‐α‐Tocopheryl Poly(ethylene glycol 1000) Succinate (TPGS) and Ketoconazole
Wacher, Vincent J., Wong, Susan, Wong, Harrison T.
Published in Journal of pharmaceutical sciences (01.01.2002)
Published in Journal of pharmaceutical sciences (01.01.2002)
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Journal Article
Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate
Wacher, Vincent J, Silverman, Jeffrey A, Wong, Susan, Tran-Tau, Paulina, Chan, Amy O, Chai, Anne, Yu, Xiang-Qing, O'Mahony, Daniel, Ramtoola, Zeibun
Published in The Journal of pharmacology and experimental therapeutics (01.10.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2002)
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Journal Article
Active secretion and enterocytic drug metabolism barriers to drug absorption1PII of original article: S0169-409X(96)003304. The article was originally published in Advanced Drug Delivery Reviews 20 (1996) 99–112.1
Wacher, Vincent J, Salphati, Laurent, Benet, Leslie Z
Published in Advanced drug delivery reviews (01.03.2001)
Published in Advanced drug delivery reviews (01.03.2001)
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Journal Article
Pharmacokinetics of cyclosporine pre- and post-liver transplantation
Hebert, Mary F, Wacher, Vincent J, Roberts, John P, Benet, Leslie Z
Published in Journal of clinical pharmacology (01.01.2003)
Published in Journal of clinical pharmacology (01.01.2003)
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Journal Article
Minimal effect of ketoconazole on cyclosporine (SangCyATM) oral absorption and first-pass metabolism in rats: evidence of a significant vehicle effect on SangCyA absorption
Wong, Susan, Wong, Harrison T., Wacher, Vincent J.
Published in Biopharmaceutics & drug disposition (01.03.2002)
Published in Biopharmaceutics & drug disposition (01.03.2002)
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