Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery
Benet, Leslie Z, Izumi, Takashi, Zhang, Yuanchao, Silverman, Jeffrey A, Wacher, Vincent J
Published in Journal of controlled release (01.11.1999)
Published in Journal of controlled release (01.11.1999)
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Journal Article
Conference Proceeding
Role of P-Glycoprotein and Cytochrome P450 3A in Limiting Oral Absorption of Peptides and Peptidomimetics
Wacher, Vincent J., Silverman, Jeffrey A., Zhang, Yuanchao, Benet, Leslie Z.
Published in Journal of pharmaceutical sciences (01.11.1998)
Published in Journal of pharmaceutical sciences (01.11.1998)
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Journal Article
Conference Proceeding
Grapefruit juice activates P-glycoprotein-mediated drug transport
SOLDNER, A, CHRISTIANS, U, SUSANTO, M, WACHER, V. J, SILVERMAN, J. A, BENET, L. Z
Published in Pharmaceutical research (01.04.1999)
Published in Pharmaceutical research (01.04.1999)
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Journal Article
The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine
Gomez, D Y, Wacher, V J, Tomlanovich, S J, Hebert, M F, Benet, L Z
Published in Clinical pharmacology and therapeutics (01.07.1995)
Published in Clinical pharmacology and therapeutics (01.07.1995)
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Journal Article
Active secretion and enterocytic drug metabolism barriers to drug absorption
Wacher, Vincent J, Salphati, Laurent, Benet, Leslie Z
Published in Advanced drug delivery reviews (01.03.2001)
Published in Advanced drug delivery reviews (01.03.2001)
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Journal Article
Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery
Benet, Leslie Z., Wu, Chi-Yuan, Hebert, Mary F., Wacher, Vincent J.
Published in Journal of controlled release (01.05.1996)
Published in Journal of controlled release (01.05.1996)
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Journal Article
Conference Proceeding
Active secretion and enterocytic drug metabolism barriers to drug absorption
Wacher, Vincent J., Salphati, Laurent, Benet, Leslie Z.
Published in Advanced drug delivery reviews (12.07.1996)
Published in Advanced drug delivery reviews (12.07.1996)
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Journal Article
2-Aryl-5-tert-butyl-1,3-dithianes and their S-oxidation products: structure-activity relationships of potent insecticides acting at the GABA-gated chloride channel
Wacher, Vincent J, Toia, Robert F, Casida, John E
Published in Journal of agricultural and food chemistry (01.03.1992)
Published in Journal of agricultural and food chemistry (01.03.1992)
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Journal Article
Peppermint Oil Enhances Cyclosporine Oral Bioavailability in Rats: Comparison with d‐α‐Tocopheryl Poly(ethylene glycol 1000) Succinate (TPGS) and Ketoconazole
Wacher, Vincent J., Wong, Susan, Wong, Harrison T.
Published in Journal of pharmaceutical sciences (01.01.2002)
Published in Journal of pharmaceutical sciences (01.01.2002)
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Journal Article
A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer
Chi, Kim N, Chia, Stephen K, Dixon, Ross, Newman, Michael J, Wacher, Vince J, Sikic, Branimir, Gelmon, Karen A
Published in Investigational new drugs (01.08.2005)
Published in Investigational new drugs (01.08.2005)
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Journal Article
Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate
Wacher, Vincent J, Silverman, Jeffrey A, Wong, Susan, Tran-Tau, Paulina, Chan, Amy O, Chai, Anne, Yu, Xiang-Qing, O'Mahony, Daniel, Ramtoola, Zeibun
Published in The Journal of pharmacology and experimental therapeutics (01.10.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2002)
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Journal Article
Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals
Wacher, V J, Liu, T, Roberts, J P, Ascher, N L, Benet, L Z
Published in Biopharmaceutics & drug disposition (01.05.1995)
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Published in Biopharmaceutics & drug disposition (01.05.1995)
Journal Article
Pharmacokinetics of cyclosporine pre- and post-liver transplantation
Hebert, Mary F, Wacher, Vincent J, Roberts, John P, Benet, Leslie Z
Published in Journal of clinical pharmacology (01.01.2003)
Published in Journal of clinical pharmacology (01.01.2003)
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Journal Article
Minimal effect of ketoconazole on cyclosporine (SangCyATM) oral absorption and first-pass metabolism in rats: evidence of a significant vehicle effect on SangCyA absorption
Wong, Susan, Wong, Harrison T., Wacher, Vincent J.
Published in Biopharmaceutics & drug disposition (01.03.2002)
Published in Biopharmaceutics & drug disposition (01.03.2002)
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Journal Article