Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles
Court, John J, Poisson, Carl, Ardzinski, Andrzej, Bilimoria, Darius, Chan, Laval, Chandupatla, Kishan, Chauret, Nathalie, Collier, Philip N, Das, Sanjoy Kumar, Denis, Francois, Dorsch, Warren, Iyer, Ganesh, Lauffer, David, L’Heureux, Lucille, Li, Pan, Luisi, Brian S, Mani, Nagraj, Nanthakumar, Suganthi, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S, Tang, Qing, Waal, Nathan D, Yannopoulos, Constantin G, Green, Jeremy
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Discovery of Novel Allosteric HCV NS5B Inhibitors. 2. Lactam-Containing Thiophene Carboxylates
Li, Pan, Dorsch, Warren, Lauffer, David J., Bilimoria, Darius, Chauret, Nathalie, Court, John J., Das, Sanjoy Kumar, Denis, Francois, Mani, Nagraj, Nanthakumar, Suganthini, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S., Stearns, Ralph, Tang, Qing, Waal, Nathan D., Green, Jeremy
Published in ACS medicinal chemistry letters (09.02.2017)
Published in ACS medicinal chemistry letters (09.02.2017)
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Integrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2: An Approach for Inhibiting Protein−Protein Interactions
Raimundo, Brian C, Oslob, Johan D, Braisted, Andrew C, Hyde, Jennifer, McDowell, Robert S, Randal, Mike, Waal, Nathan D, Wilkinson, Jennifer, Yu, Chul H, Arkin, Michelle R
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Journal Article
Tethering identifies fragment that yields potent inhibitors of human caspase-1
Fahr, Bruce T., O’Brien, Tom, Pham, Phuongly, Waal, Nathan D., Baskaran, Subramanian, Raimundo, Brian C., Lam, Joni W., Sopko, Michelle M., Purkey, Hans E., Romanowski, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
Published in Bioorganic & medicinal chemistry letters (01.02.2006)
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Identification of nonpeptidic small-molecule inhibitors of interleukin-2
Waal, Nathan D., Yang, Wenjin, Oslob, Johan D., Arkin, Michelle R., Hyde, Jennifer, Lu, Wanli, McDowell, Robert S., Yu, Chul H., Raimundo, Brian C.
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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알파-1-항트립신 결핍증(AATD)의 치료를 위한 알파-1-항트립신 조절제로서의 인돌 유도체
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Year of Publication 14.12.2022
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Year of Publication 14.12.2022
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항증식 화합물 및 이의 용도
HOOVER RUSSELL R, TANG QING, BOYD MICHAEL, DORSCH WARREN, WAAL NATHAN D, TAKEMOTO DARIN, CHANDUPATLA KISHAN, LI PAN, DENG HONGBO, DONG HUIJUN, PENNEY MARINA, LAUFFER DAVID J, YU HENRY, BEMIS GUY, JOHNSON MAC ARTHUR JR, RONKIN STEVEN, WANG TIANSHENG, CLARK MICHAEL, KUKAMI SHASHANK, COLLIER PHILIP
Year of Publication 13.01.2021
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Year of Publication 13.01.2021
Patent
Structural analysis of caspase-1 inhibitors derived from Tethering
Fahr, Bruce T., Sopko, Michelle M., Lam, Joni W., O'Brien, Tom, Waal, Nathan D., Pham, Phuongly, Purkey, Hans E., Raimundo, Brian C., Romanowski, Michael J.
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.05.2005)
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01.05.2005)
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TANG QING, RONKIN STEVEN M, GU WENXIN, WAAL NATHAN D, LI PAN, DENG HONGBO, XU JINWANG, PIERCE ALBERT CHARLES, LAUFFER DAVID J, MORRIS MARK A, COTTRELL KEVIN M, COURT JOHN J, CHARIFSON PAUL S, MAXWELL JOHN PATRICK, JACKSON KATRINA LEE, GIROUX SIMON
Year of Publication 10.11.2015
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Year of Publication 10.11.2015
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LEDEBOER MARK WILLEM, COTTRELL KEVIN MICHAEL, KENNEDY JOSEPH M, WAAL NATHAN D, LI PAN, DENG HONGBO, XU JINWANG, PIERCE ALBERT CHARLES, LAUFFER DAVID J, GREEN JEREMY, GAO HUAI, MORRIS MARK A, DUFFY JOHN P, CHARIFSON PAUL S, MAXWELL JOHN PATRICK, JACKSON KATRINA LEE, GIROUX SIMON
Year of Publication 14.01.2015
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Year of Publication 14.01.2015
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PTERIDINONE COMPOUNDS AND USES THEREOF
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Year of Publication 05.10.2023
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Year of Publication 05.10.2023
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ANTIPROLIFERATION COMPOUNDS AND USES THEREOF
WANG, Tiansheng, LAUFFER, David J, JOHNSON, Mac, Arthur, JR, WAAL, Nathan, D, YU, Henry, HOOVER, Russell, R, KULKARNI, Shashank, COLLIER, Philip, BEMIS, Guy, TAKEMOTO, Darin, DONG, Huijun, CHANDUPATLA, Kishan, CLARK, Michael, PENNEY, Marina, LI, Pan, DENG, Hongbo, RONKIN, Steven, DORSCH, Warren, BOYD, Michael, TANG, Qing
Year of Publication 05.06.2024
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Year of Publication 05.06.2024
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ANTIPROLIFERATION COMPOUNDS AND USES THEREOF
HUIJUN DONG, STEVEN RONKIN, TIANSHENG WANG, DAVID J LAUFFER, MICHAEL CLARK, HONGBO DENG, MARINA PENNEY, Pan LI, NATHAN D WAAL, Qing TANG, PHILIP COLLIER, KULKARNI, SHASHANK, GUY BEMIS, RUSSELL R HOOVER, HENRY YU, MAC ARTHUR JOHNSON JR, DARIN TAKEMOTO, MICHAEL BOYD, KISHAN CHANDUPATLA, WARREN DORSCH
Year of Publication 31.01.2024
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Year of Publication 31.01.2024
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Pteridinone compounds and uses thereof
Takemoto, Darin, Li, Pan, Gu, Wenxin, Bemis, Guy, Dorsch, Warren, Boyd, Michael, Deng, Hongbo, Johnson, Jr., Mac Arthur, Wang, Tiansheng, Ledeboer, Mark Willem, Penney, Marina, Lauffer, David, Ledford, Brian, Maltais, Francois, Deininger, David, Waal, Nathan D, Hoover, Russell R
Year of Publication 07.02.2023
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Year of Publication 07.02.2023
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Jackson, Katrina Lee, Maxwell, John Patrick, Li, Pan, Gu, Wenxin, Ronkin, Steven M, Deng, Hongbo, Court, John J, Morris, Mark A, Charifson, Paul S, Giroux, Simon, Xu, Jinwang, Pierce, Albert Charles, Cottrell, Kevin Michael, Tang, Qing, Lauffer, David J, Waal, Nathan D
Year of Publication 14.11.2023
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Year of Publication 14.11.2023
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PTERIDINONE COMPOUNDS AND USES THEREOF
DEININGER, David, WAAL, Nathan, D, LEDFORD, Brian, LAUFFER, David, J, HOOVER, Russell, R, BEMIS, Guy, GU, Wenxin, LEDEBOER, Mark, Willem, TAKEMOTO, Darin, WENG, Tiansheng, PENNEY, Marina, JOHNSON, Mac, Arthur, Jr, LI, Pan, DENG, Hongbo, DORSCH, Warren, BOYD, Michael, MALTAIS, Francois
Year of Publication 25.10.2023
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Year of Publication 25.10.2023
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Jackson, Katrina Lee, Maxwell, John Patrick, Li, Pan, Gu, Wenxin, Ronkin, Steven M, Deng, Hongbo, Court, John J, Morris, Mark A, Charifson, Paul S, Giroux, Simon, Xu, Jinwang, Pierce, Albert Charles, Cottrell, Kevin Michael, Tang, Qing, Lauffer, David J, Waal, Nathan D
Year of Publication 07.09.2023
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Year of Publication 07.09.2023
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DNA-PK INHIBITORS
LAUFFER, David J, COURT, John J, GU, Wenxin, JACKSON, Katrina Lee, MAXWELL, John Patrick, RONKIN, Steven M, XU, Jinwang, CHARIFSON, Paul S, MORRIS, Mark A, COTTRELL, Kevin M, LI, Pan, DENG, Hongbo, PIERCE, Albert Charles, GIROUX, Simon, WAAL, Nathan D, TANG, Qing
Year of Publication 09.08.2023
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Year of Publication 09.08.2023
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DNA-PK INHIBITORS
LAUFFER, David J, COURT, John J, GU, Wenxin, JACKSON, Katrina Lee, MAXWELL, John Patrick, RONKIN, Steven M, XU, Jinwang, CHARIFSON, Paul S, MORRIS, Mark A, COTTRELL, Kevin M, LI, Pan, DENG, Hongbo, PIERCE, Albert Charles, GIROUX, Simon, WAAL, Nathan D, TANG, Qing
Year of Publication 09.08.2023
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Year of Publication 09.08.2023
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PYRANO[4,3-B]INDOLE DERIVATIVES AS ALPHA-1-ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1-ANTITRYPSIN DEFICIENCY (AATD)
HALL, Amy B, COTTRELL, Kevin Michael, BRODNEY, Michael Aaron, HURLEY, Dennis James, GU, Wenxin, BOUCHER, Diane Marie, CLARK, Michael Philip, FANNING, Lev T.D, MAXWELL, John Patrick, JOHNSON, JR., Mac Arthur, DAMAGNEZ, Veronique, KESAVAN, Sarathy, JONES, Peter, TAPLEY, Timothy Lewis, THOMSON, Stephen A, SWETT, Rebecca Jane, GIROUX, Simon, WAAL, Nathan D, COLLIER, Philip Noel, TANG, Qing
Year of Publication 25.05.2023
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Year of Publication 25.05.2023
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