Development of a Virtual Screening Method for Identification of “Frequent Hitters” in Compound Libraries
Roche, Olivier, Schneider, Petra, Zuegge, Jochen, Guba, Wolfgang, Kansy, Manfred, Alanine, Alexander, Bleicher, Konrad, Danel, Franck, Gutknecht, Eva-Maria, Rogers-Evans, Mark, Neidhart, Werner, Stalder, Henri, Dillon, Michael, Sjögren, Eric, Fotouhi, Nader, Gillespie, Paul, Goodnow, Robert, Harris, William, Jones, Phil, Taniguchi, Mikio, Tsujii, Shinji, von der Saal, Wolfgang, Zimmermann, Gerd, Schneider, Gisbert
Published in Journal of medicinal chemistry (03.01.2002)
Published in Journal of medicinal chemistry (03.01.2002)
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Journal Article
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist
Clozel, M, Breu, V, Gray, G A, Kalina, B, Loeffler, B-M, Burri, K, Cassal, J-M, Hirth, G, Mueller, M, Neidhart, W
Published in The Journal of pharmacology and experimental therapeutics (01.07.1994)
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Published in The Journal of pharmacology and experimental therapeutics (01.07.1994)
Journal Article
Ro 42-5892 Is a Potent Orally Active Renin Inhibitor in Primates
Fischli, Walter, Clozel, Jean-Paul, El Amrani, Khalid, Wostl, Wolfgang, Neidhart, Werner, Stadler, Heinz, Branca, Quirico
Published in Hypertension (Dallas, Tex. 1979) (01.07.1991)
Published in Hypertension (Dallas, Tex. 1979) (01.07.1991)
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Journal Article
SULFONAMIDE-BASED ANTAGONISTS OF THE ENDOTHELIN RECEPTORS
Burri, Kaspar F., Breu, Volker, Cassal, Jean-Marie, Clozel, Martine, Fischli, Walter, Gray, Gillian A., Hirth, Georges, Löffler, Bernd-Michael, Müller, Marcel, Neidhart, Werner, Ramuz, Henri, Trzeciak, Arnold
Published in European journal of medicinal chemistry (1995)
Published in European journal of medicinal chemistry (1995)
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Journal Article
Conference Proceeding
Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design
Schneider, Gisbert, Clément-Chomienne, Odile, Hilfiger, Laurence, Schneider, Petra, Kirsch, Stefan, Böhm, Hans-Joachim, Neidhart, Werner
Published in Angewandte Chemie (International ed.) (17.11.2000)
Published in Angewandte Chemie (International ed.) (17.11.2000)
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Journal Article
Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist
Clozel, Martine, Breu, Volker, Burri, Kaspar, Cassal, Jean-Marie, Fischli, Walter, Gray, Gillian A, Hirth, Georges, Löffier, Bernd-Michael, Müller, Marcel, Neidhart, Werner, Ramuz, Henri
Published in Nature (London) (21.10.1993)
Published in Nature (London) (21.10.1993)
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Journal Article
Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm
Roux, S, Breu, V, Giller, T, Neidhart, W, Ramuz, H, Coassolo, P, Clozel, J P, Clozel, M
Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
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Published in The Journal of pharmacology and experimental therapeutics (01.12.1997)
Journal Article
Establishment of robust functional assays for the characterization of neuropeptide Y (NPY) receptors: identification of 3-(5-benzoyl-thiazol-2-ylamino)-benzonitrile as selective NPY type 5 receptor antagonist
Dautzenberg, Frank M., Higelin, Jacqueline, Pflieger, Philippe, Neidhart, Werner, Guba, Wolfgang
Published in Neuropharmacology (01.06.2005)
Published in Neuropharmacology (01.06.2005)
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Journal Article
Discovery of Ro 48-5695: A potent mixed endothelin receptor antagonist optimized from bosentan
Neidhart, Werner, Breu, Volker, Burri, Kaspar, Clozel, Martine, Hirth, Georges, Klinkhammer, Uwe, Giller, Thomas, Ramuz, Henri
Published in Bioorganic & medicinal chemistry letters (09.09.1997)
Published in Bioorganic & medicinal chemistry letters (09.09.1997)
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Journal Article
Virtual Screening for Bioactive Molecules by Evolutionary De Novo Design Special thanks to Neil R. Taylor for his help in preparation of the manuscript
Schneider, G, Clément-Chomienne, O, Hilfiger, L, Schneider, P, Kirsch, S, Böhm, HJ, Neidhart, W
Published in Angewandte Chemie International Edition (17.11.2000)
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Published in Angewandte Chemie International Edition (17.11.2000)
Journal Article
The Discovery of Nonpeptide Endothelin Receptor Antagonists. Progression towards Bosentan
Werner Neidhart, Volker Breu, Daniel Bur, Kaspar Burri, Martine Clozel, Georges Hirth, Marcel Müller, Hans P. Wessel, Henri Ramuz
Published in Chimia (01.11.1996)
Published in Chimia (01.11.1996)
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Journal Article
DERIVATI AMINOKISELINA
NEIDHART, W, VIEIRA, E, HEITZ, M.P, MUELLER, M, STADLER, H, WOSTL, W, BRANCA, Q
Year of Publication 20.01.1994
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Year of Publication 20.01.1994
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