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Erlanson, Daniel A., Fesik, Stephen W., Hubbard, Roderick E., Jahnke, Wolfgang, Jhoti, Harren
Published in Nature reviews. Drug discovery (01.09.2016)
Published in Nature reviews. Drug discovery (01.09.2016)
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MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation
Lee, Kyung-min, Giltnane, Jennifer M., Balko, Justin M., Schwarz, Luis J., Guerrero-Zotano, Angel L., Hutchinson, Katherine E., Nixon, Mellissa J., Estrada, Mónica V., Sánchez, Violeta, Sanders, Melinda E., Lee, Taekyu, Gómez, Henry, Lluch, Ana, Pérez-Fidalgo, J. Alejandro, Wolf, Melissa Magdalene, Andrejeva, Gabriela, Rathmell, Jeffrey C., Fesik, Stephen W., Arteaga, Carlos L.
Published in Cell metabolism (03.10.2017)
Published in Cell metabolism (03.10.2017)
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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor
Bröker, Joachim, Waterson, Alex G., Smethurst, Chris, Kessler, Dirk, Böttcher, Jark, Mayer, Moriz, Gmaschitz, Gerhard, Phan, Jason, Little, Andrew, Abbott, Jason R., Sun, Qi, Gmachl, Michael, Rudolph, Dorothea, Arnhof, Heribert, Rumpel, Klaus, Savarese, Fabio, Gerstberger, Thomas, Mischerikow, Nikolai, Treu, Matthias, Herdeis, Lorenz, Wunberg, Tobias, Gollner, Andreas, Weinstabl, Harald, Mantoulidis, Andreas, Krämer, Oliver, McConnell, Darryl B., W. Fesik, Stephen
Published in Journal of medicinal chemistry (10.11.2022)
Published in Journal of medicinal chemistry (10.11.2022)
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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC
Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.
Published in Molecular cell (07.05.2015)
Published in Molecular cell (07.05.2015)
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Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
Friberg, Anders, Vigil, Dominico, Zhao, Bin, Daniels, R. Nathan, Burke, Jason P, Garcia-Barrantes, Pedro M, Camper, DeMarco, Chauder, Brian A, Lee, Taekyu, Olejniczak, Edward T, Fesik, Stephen W
Published in Journal of medicinal chemistry (10.01.2013)
Published in Journal of medicinal chemistry (10.01.2013)
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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
Burns, Michael C., Qi Sun, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
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Structural biology of the Bcl-2 family of proteins
Petros, Andrew M., Olejniczak, Edward T., Fesik, Stephen W.
Published in BBA - Molecular Cell Research (01.03.2004)
Published in BBA - Molecular Cell Research (01.03.2004)
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Book Review
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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Published in Cell reports (Cambridge) (12.03.2019)
Published in Cell reports (Cambridge) (12.03.2019)
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Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins
Park, Cheol-Min, Bruncko, Milan, Adickes, Jessica, Bauch, Joy, Ding, Hong, Kunzer, Aaron, Marsh, Kennan C, Nimmer, Paul, Shoemaker, Alexander R, Song, Xiaohong, Tahir, Stephen K, Tse, Christin, Wang, Xilu, Wendt, Michael D, Yang, Xiufen, Zhang, Haichao, Fesik, Stephen W, Rosenberg, Saul H, Elmore, Steven W
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Druggability Indices for Protein Targets Derived from NMR-Based Screening Data
Hajduk, Philip J, Huth, Jeffrey R, Fesik, Stephen W
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS
Hodges, Timothy R, Abbott, Jason R, Little, Andrew J, Sarkar, Dhruba, Salovich, James M, Howes, Jennifer E, Akan, Denis T, Sai, Jiqing, Arnold, Allison L, Browning, Carrie, Burns, Michael C, Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A, Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, McConnell, Darryl B, Fesik, Stephen W
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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WIN site inhibition disrupts a subset of WDR5 function
Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.
Published in Scientific reports (03.02.2022)
Published in Scientific reports (03.02.2022)
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Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737
TAHIR, Stephen K, XIUFEN YANG, ROSENBERG, Saul H, TSE, Christin, ANDERSON, Mark G, MORGAN-LAPPE, Susan E, SARTHY, Aparna V, JUN CHEN, WARNER, Robert B, NG, Shi-Chung, FESIK, Stephen W, ELMORE, Steve W
Published in Cancer research (Chicago, Ill.) (01.02.2007)
Published in Cancer research (Chicago, Ill.) (01.02.2007)
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Activity of the Bcl-2 Family Inhibitor ABT-263 in a Panel of Small Cell Lung Cancer Xenograft Models
SHOEMAKER, Alex R, MITTEN, Michael J, BAUCH, Joy, MARSH, Kennan, TAHIR, Steven K, XIUFENYANG, TSE, Christin, FESIK, Stephen W, ROSENBERG, Saul H, ELMORE, Steven W, ADICKES, Jessica, ACKLER, Scott, REFICI, Marion, FERGUSON, Debra, OLEKSIJEW, Anatol, O'CONNOR, Jacqueline M, BAOLE WANG, FROST, David J
Published in Clinical cancer research (01.06.2008)
Published in Clinical cancer research (01.06.2008)
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Identification of ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-coa desaturase 1 as promising cancer targets from an RNAi-based screen
MORGAN-LAPPE, Susan E, TUCKER, Lora A, XIAOLI HUANG, QIAN ZHANG, SARTHY, Aparna V, ZAKULA, Dorothy, VERNETTI, Lawrence, SCHURDAK, Mark, JIEYI WANG, FESIK, Stephen W
Published in Cancer research (Chicago, Ill.) (01.05.2007)
Published in Cancer research (Chicago, Ill.) (01.05.2007)
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The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo
Ackler, Scott, Mitten, Michael J., Foster, Kelly, Oleksijew, Anatol, Refici, Marion, Tahir, Stephen K., Xiao, Yu, Tse, Christin, Frost, David J., Fesik, Stephen W., Rosenberg, Saul H., Elmore, Steven W., Shoemaker, Alexander R.
Published in Cancer chemotherapy and pharmacology (01.10.2010)
Published in Cancer chemotherapy and pharmacology (01.10.2010)
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Growth Inhibition and Radiosensitization of Glioblastoma and Lung Cancer Cells by Small Interfering RNA Silencing of Tumor Necrosis Factor Receptor-Associated Factor 2
MIN ZHENG, MORGAN-LAPPE, Susan E, JIE YANG, BOCKBRADER, Katrina M, PAMARTHY, Deepika, THOMAS, Dafydd, FESIK, Stephen W, YI SUN
Published in Cancer research (Chicago, Ill.) (15.09.2008)
Published in Cancer research (Chicago, Ill.) (15.09.2008)
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