The Disposition and Metabolism of Rofecoxib, a Potent and Selective Cyclooxygenase-2 Inhibitor, in Human Subjects
HALPIN, Rita A, PORRAS, Arturo G, SCHWARTZ, Jules I, LASSETER, Kenneth C, VYAS, Kamlesh P, BAILLIE, Thomas A, GEER, Leslie A, DAVIS, Margaret R, CUI, Donghui, DOSS, George A, WOOLF, Eric, MUSSON, Donald, MATTHEWS, Catherine, MAZENKO, Ralph
Published in Drug metabolism and disposition (01.06.2002)
Published in Drug metabolism and disposition (01.06.2002)
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METABOLISM OF ROFECOXIB IN VITRO USING HUMAN LIVER SUBCELLULAR FRACTIONS
SLAUGHTER, Donald, TAKENAGA, Norihiro, BAILLIE, Thomas A, PING LU, ASSANG, Carol, WALSH, Deborah J, ARISON, Byron H, DONGHUI CUI, HALPIN, Rita A, GEER, Leslie A, VYAS, Kamlesh P
Published in Drug metabolism and disposition (01.11.2003)
Published in Drug metabolism and disposition (01.11.2003)
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The Absorption, Distribution, Metabolism and Excretion of Rofecoxib, a Potent and Selective Cyclooxygenase-2 Inhibitor, in Rats and Dogs
HALPIN, Rita A, GEER, Leslie A, ZHANG, Kanyin E, MARKS, Tina M, DEAN, Dennis C, JONES, Allen N, MELILLO, David, DOSS, George, VYAS, Kamlesh P
Published in Drug metabolism and disposition (01.10.2000)
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Published in Drug metabolism and disposition (01.10.2000)
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Influence of β‐adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5‐HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol
Goldberg, Michael R., Sciberras, David, De Smet, Marina, Lowry, Richard, Tomasko, Lisa, Lee, Yih, Olah, Timothy V., Zhao, Jamie, Vyas, Kamlesh P., Halpin, Rita, Kari, Prasad H., James, Ian
Published in British journal of clinical pharmacology (01.07.2001)
Published in British journal of clinical pharmacology (01.07.2001)
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Mechanistic Studies on the Reversible Metabolism of Rofecoxib to 5-Hydroxyrofecoxib in the Rat: Evidence for Transient Ring Opening of a Substituted 2-Furanone Derivative Using Stable Isotope-Labeling Techniques
BAILLIE, Thomas A, HALPIN, Rita A, MELILLO, David, VYAS, Kamlesh P, MATUSZEWSKI, Bogdan K, GEER, Leslie A, CHAVEZ-ENG, Cynthia M, DEAN, Dennis, BRAUN, Matthew, DOSS, George, JONES, Allen, MARKS, Tina
Published in Drug metabolism and disposition (01.12.2001)
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Published in Drug metabolism and disposition (01.12.2001)
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Metabolism of A Dopamine D4-Selective Antagonist in Rat, Monkey, and Humans: Formation of A Novel Mercapturic Acid Adduct
Kanyin E. Zhang, Prasad H. Kari, Margaret R. Davis, George Doss, Thomas A. Baillie, Kamlesh P. Vyas
Published in Drug metabolism and disposition (01.06.2000)
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Published in Drug metabolism and disposition (01.06.2000)
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Pharmacokinetics of intravenous alendronate
Cocquyt, V, Kline, W F, Gertz, B J, Van Belle, S J, Holland, S D, DeSmet, M, Quan, H, Vyas, K P, Zhang, K E, De Grève, J, Porras, A G
Published in Journal of clinical pharmacology (01.04.1999)
Published in Journal of clinical pharmacology (01.04.1999)
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Microsomal Metabolism of the 5-Lipoxygenase Inhibitor L-739,010: Evidence for Furan Bioactivation
Zhang, Kanyin E, Naue, Jeanne A, Arison, Byron, Vyas, Kamlesh P
Published in Chemical research in toxicology (01.03.1996)
Published in Chemical research in toxicology (01.03.1996)
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In Vitro and In Vivo Studies on the Metabolism of Tirofiban
VICKERS, S, THEOHARIDES, A. D, RAMJIT, H. G, SLAUGHTER, D. E, VYAS, K. P, ARISON, B, BALANI, S. K, DAN CUI, DUNCAN, C. A, ELLIS, J. D, GORHAM, L. M, POLSKY, S. L, PRUEKSARITANONT, T
Published in Drug metabolism and disposition (01.11.1999)
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Published in Drug metabolism and disposition (01.11.1999)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 3. Approaches To Eliminate Opioid Agonist Metabolites by Using Substituted Phenylpiperazine Side Chains
Lagu, Bharat, Tian, Dake, Nagarathnam, Dhanapalan, Marzabadi, Mohammad R, Wong, Wai C, Miao, Shou W, Zhang, Fengqi, Sun, Wanying, Chiu, George, Fang, James, Forray, Carlos, Chang, Raymond S. L, Ransom, Richard W, Chen, Tsing B, O'Malley, Stacey, Zhang, Kanyin, Vyas, Kamlesh P, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Metabolism of MK-499, a Class III Antiarrhythmic Agent, in Rats and Dogs
VICKERS, S, DUNCAN, C. A, SLAUGHTER, D. E, ARISON, B. H, GREBER, T, OLAH, T. V, VYAS, K. P
Published in Drug metabolism and disposition (01.05.1998)
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Published in Drug metabolism and disposition (01.05.1998)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 4. Structure−Activity Relationship in the Dihydropyrimidine Series
Wong, Wai C, Sun, Wanying, Lagu, Bharat, Tian, Dake, Marzabadi, Mohammad R, Zhang, Fengqi, Nagarathnam, Dhanapalan, Miao, Shou W, Wetzel, John M, Peng, Jian, Forray, Carlos, Chang, Raymond S. L, Chen, Tsing B, Ransom, Richard, O'Malley, Stacey, Broten, Theodore P, Kling, Paul, Vyas, Kamlesh P, Zhang, Kanyin, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 2. Approaches To Eliminate Opioid Agonist Metabolites via Modification of Linker and 4-Methoxycarbonyl-4-phenylpiperidine Moiety
Murali Dhar, T. G, Nagarathnam, Dhanapalan, Marzabadi, Mohammad R, Lagu, Bharat, Wong, Wai C, Chiu, George, Tyagarajan, Sriram, Miao, Shou Wu, Zhang, Fengqi, Sun, Wanying, Tian, Dake, Shen, Quanrong, Zhang, Jack, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Schorn, Terry W, Chen, Tsing Bao, O'Malley, Stacy, Ransom, Richard, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Zhang, Kanyin, Gilbert, John, Pettibone, Douglas J, Patane, Michael A, Bock, Mark G, Freidinger, Roger M, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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Design and Synthesis of Novel α1 a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones
Nagarathnam, Dhanapalan, Miao, Shou Wu, Lagu, Bharat, Chiu, George, Fang, James, Murali Dhar, T. G, Zhang, Jack, Tyagarajan, Sriram, Marzabadi, Mohammad R, Zhang, Fengqi, Wong, Wai C, Sun, Wanying, Tian, Dake, Wetzel, John M, Forray, Carlos, Chang, Raymond S. L, Broten, Theodore P, Ransom, Richard W, Schorn, Terry W, Chen, Tsing B, O'Malley, Stacey, Kling, Paul, Schneck, Kathryn, Bendesky, Robert, Harrell, Charles M, Vyas, Kamlesh P, Gluchowski, Charles
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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In Vitro Metabolism of Simvastatin in Humans [sbt]Identification of metabolizing enzymes and effect of the drug on hepatic P450s
PRUEKSARITANONT, T, GORHAM, L. M, MA, B, LIU, L, YU, X, ZHAO, J. J, SLAUGHTER, D. E, ARISON, B. H, VYAS, K. P
Published in Drug metabolism and disposition (01.10.1997)
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Published in Drug metabolism and disposition (01.10.1997)
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Synthesis of the enantiomeric bay-region diol epoxides of benz[a]anthracene and chrysene
Yagi, Haruhiko, Vyas, Kamlesh P, Tada, Masao, Thakker, Dhiren R, Jerina, Donald M
Published in Journal of organic chemistry (01.03.1982)
Published in Journal of organic chemistry (01.03.1982)
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Tumorigenicity of enantiomers of chrysene 1,2-dihydrodiol and of the diastereomeric bay-region chrysene 1,2-diol-3,4-epoxides on mouse skin and in newborn mice
Chang, R L, Levin, W, Wood, A W, Yagi, H, Tada, M, Vyas, K P, Jerina, D M, Conney, A H
Published in Cancer research (Chicago, Ill.) (01.01.1983)
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Published in Cancer research (Chicago, Ill.) (01.01.1983)
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Design and synthesis of novel alpha(1a) adrenoceptor-selective antagonists. 1. Structure-activity relationship in dihydropyrimidinones
Nagarathnam, D, Miao, SW, Lagu, B, Chiu, G, Fang, J, Dhar, TGM, Zhang, J, Tyagarajan, S, Marzabadi, MR, Zhang, FQ, Wong, WC, Sun, WY, Tian, D, Wetzel, JM, Forray, C, Chang, RSL, Broten, TP, Ransom, RW, Schorn, TW, Chen, TB, O'Malley, S, Kling, P, Schneck, K, Bendesky, R, Harrell, CM, Vyas, KP, Gluchowski, C
Published in Journal of medicinal chemistry (18.11.1999)
Published in Journal of medicinal chemistry (18.11.1999)
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