Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations
den Braver-Sewradj, Shalenie P, den Braver, Michiel W, Toorneman, Robin M, van Leeuwen, Stephanie, Zhang, Yongjie, Dekker, Stefan J, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris
Published in Chemical research in toxicology (19.02.2018)
Published in Chemical research in toxicology (19.02.2018)
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Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer
den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Vermeulen, Nico P.E., Commandeur, Jan N.M., Richert, Lysiane, Vos, J. Chris
Published in Toxicology in vitro (01.06.2016)
Published in Toxicology in vitro (01.06.2016)
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Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals
Vos, J Chris, den Braver-Sewradj, Shalenie P, den Braver, Michiel W, van Dijk, Marc, Zhang, Yongjie, Dekker, Stefan J, Wijaya, Lukas, Vermeulen, Nico P E, Richert, Lysiane, Commandeur, Jan N M
Published in Current drug metabolism (01.01.2018)
Published in Current drug metabolism (01.01.2018)
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Yeast as a humanized model organism for biotransformation-related toxicity
van Leeuwen, Jolanda S, Vermeulen, Nico P E, Chris Vos, J
Published in Current drug metabolism (01.12.2012)
Published in Current drug metabolism (01.12.2012)
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Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants
Vredenburg, Galvin, den Braver-Sewradj, Shalenie, van Vugt-Lussenburg, Barbara M.A., Vermeulen, Nico P.E., Commandeur, Jan N.M., Vos, J. Chris
Published in Toxicology letters (05.01.2015)
Published in Toxicology letters (05.01.2015)
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Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid
Vredenburg, Galvin, Elias, Naura S, Venkataraman, Harini, Hendriks, Delilah F. G, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris
Published in Chemical research in toxicology (21.04.2014)
Published in Chemical research in toxicology (21.04.2014)
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Metabolism related toxicity of diclofenac in yeast as model system
van Leeuwen, Jolanda S., Vredenburg, Galvin, Dragovic, Sanja, Tjong, T.F. Jennifer, Vos, J. Chris, Vermeulen, Nico P.E.
Published in Toxicology letters (05.02.2011)
Published in Toxicology letters (05.02.2011)
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Involvement of the Pleiotropic Drug Resistance Response, Protein Kinase C Signaling, and Altered Zinc Homeostasis in Resistance of Saccharomyces cerevisiae to Diclofenac
VAN LEEUWEN, Jolanda S, VERMEULEN, Nico P. E, VOS, J. Chris
Published in Applied and Environmental Microbiology (01.09.2011)
Published in Applied and Environmental Microbiology (01.09.2011)
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Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
Ortega Ugalde, Sandra, Boot, Maikel, Commandeur, Jan N. M., Jennings, Paul, Bitter, Wilbert, Vos, J. Chris
Published in Applied microbiology and biotechnology (01.05.2019)
Published in Applied microbiology and biotechnology (01.05.2019)
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Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners
Ortega Ugalde, Sandra, de Koning, Coen P., Wallraven, Kerstin, Bruyneel, Ben, Vermeulen, Nico P. E., Grossmann, Tom N., Bitter, Wilbert, Commandeur, Jan N. M., Vos, J. Chris
Published in Applied microbiology and biotechnology (01.11.2018)
Published in Applied microbiology and biotechnology (01.11.2018)
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Practical Guidelines to Redesign Introductory Chemistry Courses Using a Flexible and Adaptive Blended Format
Scholten, Danny J, Wijtmans, Maikel, Dekker, Stefan J, Vuuregge, Anna H, Boon, Erik J. J, Vos, J. Chris, Siderius, Marco, Westbroek, Hanna, van Muijlwijk-Koezen, Jacqueline E
Published in Journal of chemical education (14.12.2021)
Published in Journal of chemical education (14.12.2021)
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Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity
Zhang, Yongjie, den Braver-Sewradj, Shalenie P., Vos, J. Chris, Vermeulen, Nico P.E., Commandeur, Jan N.M.
Published in Toxicology letters (05.06.2017)
Published in Toxicology letters (05.06.2017)
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A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants
Luirink, Rosa A., Dekker, Stefan J., Capoferri, Luigi, Janssen, Laura F.H., Kuiper, Cynthia L., Ari, Mehmet E., Vermeulen, Nico P.E., Vos, J. Chris, Commandeur, Jan N.M., Geerke, Daan P.
Published in Journal of inorganic biochemistry (01.07.2018)
Published in Journal of inorganic biochemistry (01.07.2018)
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Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors
den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Baze, Audrey, Decorde, Joachim, Fonsi, Massimiliano, Bachellier, Philippe, Vermeulen, Nico P.E., Commandeur, Jan N.M., Richert, Lysiane, Vos, J. Chris
Published in European journal of pharmaceutical sciences (15.11.2017)
Published in European journal of pharmaceutical sciences (15.11.2017)
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Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine
Huseinovic, Angelina, van Dijk, Marc, Vermeulen, Nico P.E., van Leeuwen, Fred, Kooter, Jan M., Vos, J. Chris
Published in Toxicology in vitro (01.03.2018)
Published in Toxicology in vitro (01.03.2018)
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