Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1
Goldberg, Matthew S., Pisani, Antonio, Haburcak, Marian, Vortherms, Timothy A., Kitada, Tohru, Costa, Cinzia, Tong, Youren, Martella, Giuseppina, Tscherter, Anne, Martins, Andrea, Bernardi, Giorgio, Roth, Bryan L., Pothos, Emmanuel N., Calabresi, Paolo, Shen, Jie
Published in Neuron (Cambridge, Mass.) (17.02.2005)
Published in Neuron (Cambridge, Mass.) (17.02.2005)
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Suppression of superoxide/hydrogen peroxide production at mitochondrial site IQ decreases fat accumulation, improves glucose tolerance and normalizes fasting insulin concentration in mice fed a high-fat diet
Watson, Mark A., Brar, Harmanmeet, Gibbs, Edwin T., Wong, Hoi-Shan, Dighe, Pratiksha A., McKibben, Bryan, Riedmaier, Stephan, Siu, Amy, Polakowski, James S., Segreti, Jason A., Liu, Xiaoqin, Chung, SeungWon, Pliushchev, Y. Marina, Gesmundo, Nathan, Wang, Zhi, Vortherms, Timothy A., Brand, Martin D.
Published in Free radical biology & medicine (01.08.2023)
Published in Free radical biology & medicine (01.08.2023)
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Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222
Singh, Ashvani K, Fan, Yihong, Balut, Corina, Alani, Sara, Manelli, Arlene M, Swensen, Andrew M, Jia, Ying, Neelands, Torben R, Vortherms, Timothy A, Liu, Bo, Searle, Xenia B, Wang, Xueqing, Gao, Wenqing, Hwang, Tzyh-Chang, Ren, Hong Y, Cyr, Douglas, Kym, Philip R, Conrath, Katja, Tse, Chris
Published in The Journal of pharmacology and experimental therapeutics (01.01.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2020)
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Journal Article
In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists : Trends across multiple chemical series
NERSESIAN, Diana L, BLACK, Lawrence A, MILLER, Thomas R, VORTHERMS, Timothy A, ESBENSHADE, Timothy A, HANCOCK, Arthur A, COWART, Marlon D
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Structure−Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H4 Receptor Ligands
Altenbach, Robert J, Adair, Ronald M, Bettencourt, Brian M, Black, Lawrence A, Fix-Stenzel, Shannon R, Gopalakrishnan, Sujatha M, Hsieh, Gin C, Liu, Huaqing, Marsh, Kennan C, McPherson, Michael J, Milicic, Ivan, Miller, Thomas R, Vortherms, Timothy A, Warrior, Usha, Wetter, Jill M, Wishart, Neil, Witte, David G, Honore, Prisca, Esbenshade, Timothy A, Hancock, Arthur A, Brioni, Jorge D, Cowart, Marlon D
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats
Scott, Victoria E., Vortherms, Timothy A., Niforatos, Wende, Swensen, Andrew M., Neelands, Torben, Milicic, Ivan, Banfor, Patricia N., King, Andrew, Zhong, Chengmin, Simler, Gricelda, Zhan, Cenchen, Bratcher, Natalie, Boyce-Rustay, Janel M., Zhu, Chang Z., Bhatia, Pramila, Doherty, George, Mack, Helmut, Stewart, Andrew O., Jarvis, Michael F.
Published in Biochemical pharmacology (01.02.2012)
Published in Biochemical pharmacology (01.02.2012)
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Identification of the Molecular Mechanisms by Which the Diterpenoid Salvinorin A Binds to κ-Opioid Receptors
Yan, Feng, Mosier, Philip D, Westkaemper, Richard B, Stewart, Jeremy, Zjawiony, Jordan K, Vortherms, Timothy A, Sheffler, Douglas J, Roth, Bryan L
Published in Biochemistry (Easton) (21.06.2005)
Published in Biochemistry (Easton) (21.06.2005)
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cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia
Liu, Huaqing, Altenbach, Robert J, Carr, Tracy L, Chandran, Prasant, Hsieh, Gin C, Lewis, La Geisha R, Manelli, Arlene M, Milicic, Ivan, Marsh, Kennan C, Miller, Thomas R, Strakhova, Marina I, Vortherms, Timothy A, Wakefield, Brian D, Wetter, Jill M, Witte, David G, Honore, Prisca, Esbenshade, Timothy A, Brioni, Jorge D, Cowart, Marlon D
Published in Journal of medicinal chemistry (27.11.2008)
Published in Journal of medicinal chemistry (27.11.2008)
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Differential Helical Orientations among Related G Protein-coupled Receptors Provide a Novel Mechanism for Selectivity: STUDIES WITH SALVINORIN A AND THE κ-OPIOID RECEPTOR
Vortherms, Timothy A, Mosier, Philip D, Westkaemper, Richard B, Roth, Bryan L
Published in The Journal of biological chemistry (02.02.2007)
Published in The Journal of biological chemistry (02.02.2007)
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Mechanistic insights into the analgesic efficacy of A-1264087, a novel neuronal Ca(2+) channel blocker that reduces nociception in rat preclinical pain models
Zhu, Chang Z, Vortherms, Timothy A, Zhang, Min, Xu, Jun, Swensen, Andrew M, Niforatos, Wende, Neelands, Torben, Milicic, Ivan, Lewis, La Geisha, Zhong, Chengmin, Gauvin, Donna, Mikusa, Joseph, Zhan, Cenchen, Pai, Madhavi, Roderwald, Victoria, Chu, Katharine L, Cole, Emily E, Bespalov, Anton, Searle, Xenia B, McGaraughty, Steve, Bitner, Robert S, Jarvis, Michael F, Bannon, Anthony W, Joshi, Shailen K, Scott, Victoria E, Lee, Chih-Hung
Published in The journal of pain (01.04.2014)
Published in The journal of pain (01.04.2014)
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Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain
Beebe, Xenia, Yeung, Clinton M., Darczak, Daria, Shekhar, Shashank, Vortherms, Timothy A., Miller, Loan, Milicic, Ivan, Swensen, Andrew M., Zhu, Chang Z., Banfor, Patricia, Wetter, Jill M., Marsh, Kennan C., Jarvis, Michael F., Scott, Victoria E., Schrimpf, Michael R., Lee, Chih-Hung
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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Journal Article
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers
Doherty, George A., Bhatia, Pramila, Vortherms, Timothy A., Marsh, Kennan C., Wetter, Jill M., Mack, Helmut, Scott, Victoria E., Jarvis, Michael F., Stewart, Andrew O.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Journal Article
Mechanistic Insights Into the Analgesic Efficacy of A-1264087, a Novel Neuronal Ca2+ Channel Blocker That Reduces Nociception in Rat Preclinical Pain Models
Zhu, Chang Z, Vortherms, Timothy A, Zhang, Min, Xu, Jun, Swensen, Andrew M, Niforatos, Wende, Neelands, Torben, Milicic, Ivan, Lewis, La Geisha, Zhong, Chengmin, Gauvin, Donna, Mikusa, Joseph, Zhan, Cenchen, Pai, Madhavi, Roderwald, Victoria, Chu, Katharine L, Cole, Emily E, Bespalov, Anton, Searle, Xenia B, McGaraughty, Steve, Bitner, Robert S, Jarvis, Michael F, Bannon, Anthony W, Joshi, Shailen K, Scott, Victoria E, Lee, Chih-Hung
Published in The journal of pain (01.04.2014)
Published in The journal of pain (01.04.2014)
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Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels
Vortherms, Timothy A, Swensen, Andrew M, Niforatos, Wende, Limberis, James T, Neelands, Torben R, Janis, Richard S, Thimmapaya, Rama, Donnelly-Roberts, Diana L, Namovic, Marian T, Zhang, Di, Brent Putman, C, Martin, Ruth L, Surowy, Carol S, Jarvis, Michael F, Scott, Victoria E
Published in Inflammation research (01.07.2011)
Published in Inflammation research (01.07.2011)
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Comparative analysis of inactivated-state block of N-type (Cav2.2) calcium channels
Vortherms, Timothy A., Swensen, Andrew M., Niforatos, Wende, Limberis, James T., Neelands, Torben R., Janis, Richard S., Thimmapaya, Rama, Donnelly-Roberts, Diana L., Namovic, Marian T., Zhang, Di, Brent Putman, C., Martin, Ruth L., Surowy, Carol S., Jarvis, Michael F., Scott, Victoria E.
Published in Inflammation research (01.07.2011)
Published in Inflammation research (01.07.2011)
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Cloning and characterization of the monkey histamine H3 receptor isoforms
STRAKHOVA, Marina I, FOX, Gerard B, CARR, Tracy L, WITTE, David G, VORTHERMS, Timothy A, MANELLI, Arlene M, MILLER, Thomas R, YAO, Betty B, BRIONI, Jorge D, ESBENSHADE, Timothy A
Published in European journal of pharmacology (28.12.2008)
Published in European journal of pharmacology (28.12.2008)
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An automated electrophysiological assay for differentiating Ca(v)2.2 inhibitors based on state dependence and kinetics
Swensen, Andrew M, Niforatos, Wende, Vortherms, Timothy A, Perner, Richard J, Li, Tao, Schrimpf, Michael R, Scott, Victoria E, Lee, Lance, Jarvis, Michael F, McGaraughty, Steve
Published in Assay and drug development technologies (01.12.2012)
Published in Assay and drug development technologies (01.12.2012)
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