Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy
Cabezas-Wallscheid, Nina, Buettner, Florian, Sommerkamp, Pia, Klimmeck, Daniel, Ladel, Luisa, Thalheimer, Frederic B., Pastor-Flores, Daniel, Roma, Leticia P., Renders, Simon, Zeisberger, Petra, Przybylla, Adriana, Schönberger, Katharina, Scognamiglio, Roberta, Altamura, Sandro, Florian, Carolina M., Fawaz, Malak, Vonficht, Dominik, Tesio, Melania, Collier, Paul, Pavlinic, Dinko, Geiger, Hartmut, Schroeder, Timm, Benes, Vladimir, Dick, Tobias P., Rieger, Michael A., Stegle, Oliver, Trumpp, Andreas
Published in Cell (18.05.2017)
Published in Cell (18.05.2017)
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Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states
Triana, Sergio, Vonficht, Dominik, Jopp-Saile, Lea, Raffel, Simon, Lutz, Raphael, Leonce, Daniel, Antes, Magdalena, Hernández-Malmierca, Pablo, Ordoñez-Rueda, Diana, Ramasz, Beáta, Boch, Tobias, Jann, Johann-Christoph, Nowak, Daniel, Hofmann, Wolf-Karsten, Müller-Tidow, Carsten, Hübschmann, Daniel, Alexandrov, Theodore, Benes, Vladimir, Trumpp, Andreas, Paulsen, Malte, Velten, Lars, Haas, Simon
Published in Nature immunology (01.12.2021)
Published in Nature immunology (01.12.2021)
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Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer
Demel, Uta M, Böger, Marlitt, Yousefian, Schayan, Grunert, Corinna, Zhang, Le, Hotz, Paul W, Gottschlich, Adrian, Köse, Hazal, Isaakidis, Konstandina, Vonficht, Dominik, Grünschläger, Florian, Rohleder, Elena, Wagner, Kristina, Dönig, Judith, Igl, Veronika, Brzezicha, Bernadette, Baumgartner, Francis, Habringer, Stefan, Löber, Jens, Chapuy, Björn, Weidinger, Carl, Kobold, Sebastian, Haas, Simon, Busse, Antonia B, Müller, Stefan, Wirth, Matthias, Schick, Markus, Keller, Ulrich
Published in The Journal of clinical investigation (01.05.2022)
Published in The Journal of clinical investigation (01.05.2022)
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P323: UNCOVERING SUBCLONAL METABOLIC VULNERABILITIES IN ACUTE LYMPHOBLASTIC LEUKEMIA AT SINGLE CELL RESOLUTION
Mönnig, Maximilian, Antes, Magdalena, Beneyto‐Calabuig, Sergi, Vonficht, Dominik, Marot‐Lassauzaie, Valérie, Besiriduo, Eleni, Müller‐Tidow, Carsten, Haghverdi, Laleh, Haas, Simon, Velten, Lars, Raffel, Simon
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT
Hartmann, Mark, Schönung, Maximilian, Rajak, Jovana, Hey, Joschka, Maurer, Valentin, Hai, Ling, Staeble, Sina, Langstein, Jens, Bauer, Katharina, Hakobyan, Mariam, Jardine, Laura, Bohler, Sheila, Vonficht, Dominik, Maag, Abdul-Habib, Lebrecht, Dirk, Bernt, Katrin M., Roelz, Roland, Boch, Tobias, Khabirova, Eleonora, Lutsik, Pavlo, Haas, Simon, Haniffa, Muzlifah, Behjati, Sam, Mallm, Jan-Philipp, Buske, Christian, Milsom, Michael D., Fröhling, Stefan, Bonder, Marc-Jan, Niemeyer, Charlotte, Flotho, Christian, Plass, Christoph, Erlacher, Miriam, Schlesner, Matthias, Lipka, Daniel B.
Published in EJC paediatric oncology (01.12.2023)
Published in EJC paediatric oncology (01.12.2023)
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S206: ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT
Hartmann, Mark, Schönung, Maximilian, Rajak, Jovana, Hey, Joschka, Maurer, Valentin, Hai, Ling, Staeble, Sina, Langstein, Jens, Bauer, Katharina, Hakobyan, Mariam, Jardine, Laura, Bohler, Sheila, Vonficht, Dominik, Maag, Abdul-Habib, Lebrecht, Dirk, Bernt, Kathrin, Rölz, Roland, Boch, Tobias, Khabirova, Eleonora, Lutsik, Pavlo, Haas, Simon, Haniffa, Muzlifah, Behjati, Sam, Mallm, Jan-Philipp, Buske, Christian, Milsom, Michael, Fröhling, Stefan, Bonder, Marc-Jan, Plass, Christoph, Niemeyer, Charlotte, Flotho, Christian, Erlacher, Miriam, Schlesner, Matthias, Lipka, Daniel B.
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Targeting PGLYRP1 promotes antitumor immunity while inhibiting autoimmune neuroinflammation
Schnell, Alexandra, Huang, Linglin, Regan, Brianna M. L., Singh, Vasundhara, Vonficht, Dominik, Bollhagen, Alina, Wang, Mona, Hou, Yu, Bod, Lloyd, Sobel, Raymond A., Chihara, Norio, Madi, Asaf, Anderson, Ana C., Regev, Aviv, Kuchroo, Vijay K.
Published in Nature immunology (01.11.2023)
Published in Nature immunology (01.11.2023)
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Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice
Funk, Maja C, Gleixner, Jan G, Heigwer, Florian, Vonficht, Dominik, Valentini, Erica, Aydin, Zeynep, Tonin, Elena, Del Prete, Stefania, Mahara, Sylvia, Throm, Yannick, Hetzer, Jenny, Heide, Danijela, Stegle, Oliver, Odom, Duncan T, Feldmann, Angelika, Haas, Simon, Heikenwalder, Mathias, Boutros, Michael
Published in Developmental cell (18.12.2023)
Published in Developmental cell (18.12.2023)
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Antigen presentation safeguards the integrity of the hematopoietic stem cell pool
Hernández-Malmierca, Pablo, Vonficht, Dominik, Schnell, Alexandra, Uckelmann, Hannah J., Bollhagen, Alina, Mahmoud, Mohamed A.A., Landua, Sophie-Luise, van der Salm, Elise, Trautmann, Christine L., Raffel, Simon, Grünschläger, Florian, Lutz, Raphael, Ghosh, Michael, Renders, Simon, Correia, Nádia, Donato, Elisa, Dixon, Karin O., Hirche, Christoph, Andresen, Carolin, Robens, Claudia, Werner, Paula S., Boch, Tobias, Eisel, David, Osen, Wolfram, Pilz, Franziska, Przybylla, Adriana, Klein, Corinna, Buchholz, Frank, Milsom, Michael D., Essers, Marieke A.G., Eichmüller, Stefan B., Hofmann, Wolf-Karsten, Nowak, Daniel, Hübschmann, Daniel, Hundemer, Michael, Thiede, Christian, Bullinger, Lars, Müller-Tidow, Carsten, Armstrong, Scott A., Trumpp, Andreas, Kuchroo, Vijay K., Haas, Simon
Published in Cell stem cell (05.05.2022)
Published in Cell stem cell (05.05.2022)
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3072 – UNDERSTANDING THE RELATIONSHIP BETWEEN STEM CELL HETEROGENEITY AND RECONSTITUTION KINETICS IN HEMATOPOIETIC SYSTEMS: INSIGHTS FROM IN-DEPTH SINGLE-CELL ANALYSIS OF CLONALLY-DERIVED SYSTEMS
Grünschläger, Florian, Al-Sabah, Jude, Correa, Esther Rodriguez, Kumpost, Vojtech, Malmierca, Pablo Hernandez, Mathioudaki, Anna, Anstee, Natasha, Gräsel, Julius, Vonficht, Dominik, Zaugg, Judith, Mikut, Ralf, Milsom, Michael, Trumpp, Andreas, Hübschmann, Daniel, Haas, Simon
Published in Experimental hematology (2023)
Published in Experimental hematology (2023)
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Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level
John, Lukas, Poos, Alexandra M., Brobeil, Alexander, Schinke, Carolina, Huhn, Stefanie, Prokoph, Nina, Lutz, Raphael, Wagner, Barbara, Zangari, Maurizio, Tirier, Stephan M., Mallm, Jan-Philipp, Schumacher, Sabrina, Vonficht, Dominik, Solé-Boldo, Llorenç, Quick, Sabine, Steiger, Simon, Przybilla, Moritz J., Bauer, Katharina, Baumann, Anja, Hemmer, Stefan, Rehnitz, Christoph, Lückerath, Christian, Sachpekidis, Christos, Mechtersheimer, Gunhild, Haberkorn, Uwe, Dimitrakopoulou-Strauss, Antonia, Reichert, Philipp, Barlogie, Bart, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Hillengass, Jens, Rasche, Leo, Haas, Simon F., van Rhee, Frits, Rippe, Karsten, Raab, Marc S., Sauer, Sandra, Weinhold, Niels
Published in Nature communications (17.08.2023)
Published in Nature communications (17.08.2023)
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Globally altered epigenetic landscape and delayed osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone
Lutsik, Pavlo, Baude, Annika, Mancarella, Daniela, Öz, Simin, Kühn, Alexander, Toth, Reka, Hey, Joschka, Toprak, Umut H., Lim, Jinyeong, Nguyen, Viet Ha, Jiang, Chao, Mayakonda, Anand, Hartmann, Mark, Rosemann, Felix, Breuer, Kersten, Vonficht, Dominik, Grünschläger, Florian, Lee, Suman, Schuhmacher, Maren Kirstin, Kusevic, Denis, Jauch, Anna, Weichenhan, Dieter, Zustin, Jozef, Schlesner, Matthias, Haas, Simon, Park, Joo Hyun, Park, Yoon Jung, Oppermann, Udo, Jeltsch, Albert, Haller, Florian, Fellenberg, Jörg, Lindroth, Anders M., Plass, Christoph
Published in Nature communications (27.10.2020)
Published in Nature communications (27.10.2020)
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Bone Marrow Immune Signatures in Multiple Myeloma Are Linked to Tumor Heterogeneity and Treatment Outcome
Steiger, Simon, Lutz, Raphael, Prokoph, Nina, Palit, Subarna, Tirier, Stephan M, Reichert, Philipp, Baumann, Anja, Hefner, Nadine, Schumacher, Sabrina, Vonficht, Dominik, Grünschläger, Florian, Poos, Alexandra M, John, Lukas, Haghverdi, Laleh, Mallm, Jan-Philipp, Mai, Elias K, Friedrich, Mirco, Kriegsmann, Katharina, Awwad, Mohamed H.S., Jauch, Anna, Bertsch, Uta, Tichy, Diana, Müller-Tidow, Carsten, Schroers, Roland, Salwender, Hans, Besemer, Britta, Fenk, Roland, Weisel, Katja, Goldschmidt, Hartmut, Huhn, Stefanie, Hundemer, Michael, Rippe, Karsten, Haas, Simon, Weinhold, Niels, Raab, Marc S
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Multi-Omics Profiling of JMML HSPCs Reveals Onco-Fetal Reprogramming and Identifies Novel Prognostic Biomarkers and Therapeutic Targets in High-Risk JMML
Hartmann, Mark, Hai, Ling, Hey, Joschka, Schönung, Maximilian, Maurer, Valentin, Rajak, Jovana, Staeble, Sina, Langstein, Jens, Bauer, Katharina, Hakobyan, Mariam, Jardine, Laura, Bohler, Sheila, Vonficht, Dominik, Maag, Abdul-Habib, Lebrecht, Dirk, Bernt, Kathrin M., Roelz, Roland, Boch, Tobias, Khabirova, Eleonora, Lutsik, Pavlo, Stegle, Oliver, Haas, Simon, Haniffa, Muzlifah, Behjati, Sam, Mallm, Jan-Philipp, Buske, Christian, Fröhling, Stefan, Plass, Christoph, Niemeyer, Charlotte M., Flotho, Christian, Bonder, Marc Jan, Erlacher, Miriam, Schlesner, Matthias, Lipka, Daniel B.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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METB-03. SOLID PEDIATRIC TUMORS IN MICE REVEAL MODEL-SPECIFIC GLOBAL DNA METHYLATION AND CNV PROFILES CORRESPONDING TO HUMAN COUNTERPARTS
Schoof, Melanie, Zheng, Tuyu, Sill, Martin, Imle, Roland, Hofmann, Nina, Ernst, Kati, Vonficht, Dominik, Chan, Chun Ho, Cais, Alessia, Holland-Letz, Tim, Postlmayr, Andreas, Shiraishi, Ryo, Wang, Wanchen, Morcavallo, Alaide, Spohn, Michael, Göbel, Carolin, Niesen, Judith, Peter, Levke-Sophie, Eckhardt, Alicia, Bourdeaut, Franck, Han, Zhi-Yan, Pei, Yanxin, Murad, Najiba, Swartling, Fredrik J, Taylor, Jessica, Gilbertson, Richard J, Dottermusch, Matthias, Kerl, Kornelius, Glass, Rainer, Cheng, Jiying, Horstmann, Martin A, Nollau, Peter, Wolters-Eisfeld, Gerrit, Zhao, Haotian, Sturm, Dominik, Chesler, Louis, Haas, Simon, Weiss, William A, Northcott, Paul A, Kutscher, Lena M, Stücklin, Ana Guerreiro, Ayrault, Olivier, Neumann, Julia E, Kawauchi, Daisuke, Jones, David, Pfister, Stefan M, Pajtler, Kristian, Banito, Ana, Schüller, Ulrich, Zuckermann, Marc
Published in Neuro-oncology (Charlottesville, Va.) (18.06.2024)
Published in Neuro-oncology (Charlottesville, Va.) (18.06.2024)
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3019 – SINGLE-CELL PROTEO-GENOMIC REFERENCE MAPS OF THE HEMATOPOIETIC SYSTEM ENABLE THE PURIFICATION AND MASSIVE PROFILING OF PRECISELY DEFINED CELL STATES
Vonficht, Dominik, Triana, Sergio, Jopp-Saile, Lea, Raffel, Simon, Lutz, Raphael, Leonce, Daniel, Antes, Magdalena, Hernández-Malmierca, Pablo, Ordoñez-Rueda, Diana, Ramasz, Beáta, Boch, Tobias, Jann, Johann-Christoph, Nowak, Daniel, Hofmann, Wolf-Karsten, Müller-Tidow, Carsten, Hübschmann, Daniel, Alexandrov, Theodore, Benes, Vladimir, Trumpp, Andreas, Paulsen, Malte, Velten, Lars, Haas, Simon
Published in Experimental hematology (2022)
Published in Experimental hematology (2022)
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Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial
Schubert, Maria-Luisa, Schmitt, Anita, Hückelhoven-Krauss, Angela, Neuber, Brigitte, Kunz, Alexander, Waldhoff, Philip, Vonficht, Dominik, Yousefian, Schayan, Jopp-Saile, Lea, Wang, Lei, Korell, Felix, Keib, Anna, Michels, Birgit, Haas, Dominik, Sauer, Tim, Derigs, Patrick, Kulozik, Andreas, Kunz, Joachim, Pavel, Petra, Laier, Sascha, Wuchter, Patrick, Schmier, Johann, Bug, Gesine, Lang, Fabian, Gökbuget, Nicola, Casper, Jochen, Görner, Martin, Finke, Jürgen, Neubauer, Andreas, Ringhoffer, Mark, Wolleschak, Denise, Brüggemann, Monika, Haas, Simon, Ho, Anthony D, Müller-Tidow, Carsten, Dreger, Peter, Schmitt, Michael
Published in Journal of hematology and oncology (22.07.2023)
Published in Journal of hematology and oncology (22.07.2023)
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S206: ONCO‐FETAL REPROGRAMMING DRIVES HIGH‐RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI‐CD52 TREATMENT
Hartmann, Mark, Schönung, Maximilian, Rajak, Jovana, Hey, Joschka, Maurer, Valentin, Hai, Ling, Staeble, Sina, Langstein, Jens, Bauer, Katharina, Hakobyan, Mariam, Jardine, Laura, Bohler, Sheila, Vonficht, Dominik, Maag, Abdul‐Habib, Lebrecht, Dirk, Bernt, Kathrin, Rölz, Roland, Boch, Tobias, Khabirova, Eleonora, Lutsik, Pavlo, Haas, Simon, Haniffa, Muzlifah, Behjati, Sam, Mallm, Jan‐Philipp, Buske, Christian, Milsom, Michael, Fröhling, Stefan, Bonder, Marc‐Jan, Plass, Christoph, Niemeyer, Charlotte, Flotho, Christian, Erlacher, Miriam, Schlesner, Matthias, Lipka, Daniel B.
Published in HemaSphere (01.08.2023)
Published in HemaSphere (01.08.2023)
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Transition out of HSC Dormancy By a Continuous Upregulation of Metabolism Is Controlled Via Dietary Vitamin A/ Retinoic Acid Signaling
Cabezas-Wallscheid, Nina, Buettner, Florian, Klimmeck, Daniel, Sommerkamp, Pia, Ladel, Luisa, Thalheimer, Frederic B, Renders, Simon, Pastor, Daniel, Roma, Leticia, Zeisberger, Petra, Przybylla, Adriana, Scognamiglio, Roberta, Altamura, Sandro, Florian, Carolina M., Fawaz, Malak, Vonficht, Dominik, Collier, Paul, Pavlinik, Dinko, Geiger, Hartmut, Schröder, Timm, Benes, Vladimir, Dick, Tobias P., Rieger, Michael A, Stegle, Oliver, Trumpp, Andreas
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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