Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development
Kamerzell, Tim J., Esfandiary, Reza, Joshi, Sangeeta B., Middaugh, C. Russell, Volkin, David B.
Published in Advanced drug delivery reviews (01.10.2011)
Published in Advanced drug delivery reviews (01.10.2011)
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Journal Article
Evaluating the Role of the Air-Solution Interface on the Mechanism of Subvisible Particle Formation Caused by Mechanical Agitation for an IgG1 mAb
Ghazvini, Saba, Kalonia, Cavan, Volkin, David B., Dhar, Prajnaparamita
Published in Journal of pharmaceutical sciences (01.05.2016)
Published in Journal of pharmaceutical sciences (01.05.2016)
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Journal Article
Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies
Kumru, Ozan S., Joshi, Sangeeta B., Smith, Dawn E., Middaugh, C. Russell, Prusik, Ted, Volkin, David B.
Published in Biologicals (01.09.2014)
Published in Biologicals (01.09.2014)
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Journal Article
A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
Weidenbacher, Payton A-B, Sanyal, Mrinmoy, Friedland, Natalia, Tang, Shaogeng, Arunachalam, Prabhu S, Hu, Mengyun, Kumru, Ozan S, Morris, Mary Kate, Fontenot, Jane, Shirreff, Lisa, Do, Jonathan, Cheng, Ya-Chen, Vasudevan, Gayathri, Feinberg, Mark B, Villinger, Francois J, Hanson, Carl, Joshi, Sangeeta B, Volkin, David B, Pulendran, Bali, Kim, Peter S
Published in Nature communications (17.04.2023)
Published in Nature communications (17.04.2023)
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Journal Article
Effects of Protein Conformation, Apparent Solubility, and Protein–Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody
Kalonia, Cavan, Toprani, Vishal, Toth, Ronald, Wahome, Newton, Gabel, Ian, Middaugh, C. Russell, Volkin, David B
Published in The journal of physical chemistry. B (28.07.2016)
Published in The journal of physical chemistry. B (28.07.2016)
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Journal Article
Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody
Zhang, Jun, Woods, Christopher, He, Feng, Han, Mei, Treuheit, Michael J, Volkin, David B
Published in Biochemistry (Easton) (18.09.2018)
Published in Biochemistry (Easton) (18.09.2018)
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Journal Article
Effect of solution properties on the counting and sizing of subvisible particle standards as measured by light obscuration and digital imaging methods
Werk, Tobias, Volkin, David B., Mahler, Hanns-Christian
Published in European journal of pharmaceutical sciences (12.03.2014)
Published in European journal of pharmaceutical sciences (12.03.2014)
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Journal Article
Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity
Arora, Jayant, Hu, Yue, Esfandiary, Reza, Sathish, Hasige A, Bishop, Steven M, Joshi, Sangeeta B, Middaugh, C Russell, Volkin, David B, Weis, David D
Published in mAbs (16.11.2016)
Published in mAbs (16.11.2016)
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Journal Article
Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration
Hu, Yue, Kumru, Ozan S., Xiong, Jian, Antunez, Lorena R., Hickey, John, Wang, Yang, Cavacini, Lisa, Klempner, Mark, Joshi, Sangeeta B., Volkin, David B.
Published in Journal of pharmaceutical sciences (01.01.2020)
Published in Journal of pharmaceutical sciences (01.01.2020)
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Journal Article
Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1
Hu, Yue, Arora, Jayant, Joshi, Sangeeta B., Esfandiary, Reza, Middaugh, C. Russell, Weis, David D., Volkin, David B.
Published in Journal of pharmaceutical sciences (01.01.2020)
Published in Journal of pharmaceutical sciences (01.01.2020)
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Journal Article
Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication
Kumar, Prashant, Bird, Christopher, Holland, David, Joshi, Sangeeta B., Volkin, David B.
Published in Human vaccines & immunotherapeutics (30.12.2022)
Published in Human vaccines & immunotherapeutics (30.12.2022)
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Journal Article
Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody
Majumdar, Ranajoy, Manikwar, Prakash, Hickey, John M, Samra, Hardeep S, Sathish, Hasige A, Bishop, Steven M, Middaugh, C. Russell, Volkin, David B, Weis, David D
Published in Biochemistry (Easton) (14.05.2013)
Published in Biochemistry (Easton) (14.05.2013)
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Journal Article
Development of a Microflow Digital Imaging Assay to Characterize Protein Particulates During Storage of a High Concentration IgG1 Monoclonal Antibody Formulation
Wuchner, Klaus, Büchler, Jochen, Spycher, Rene, Dalmonte, Paul, Volkin, David B.
Published in Journal of pharmaceutical sciences (01.08.2010)
Published in Journal of pharmaceutical sciences (01.08.2010)
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Journal Article
Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
Weidenbacher, Payton A-B, Sanyal, Mrinmoy, Friedland, Natalia, Tang, Shaogeng, Arunachalam, Prabhu S, Hu, Mengyun, Kumru, Ozan S, Morris, Mary Kate, Fontenot, Jane, Shirreff, Lisa, Do, Jonathan, Cheng, Ya-Chen, Vasudevan, Gayathri, Feinberg, Mark B, Villinger, Francois J, Hanson, Carl, Joshi, Sangeeta B, Volkin, David B, Pulendran, Bali, Kim, Peter S
Published in Nature communications (05.10.2023)
Published in Nature communications (05.10.2023)
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Journal Article
The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate
Lee, Shwu-Maan, Wu, Yimin, Hickey, John M, Miura, Kazutoyo, Whitaker, Neal, Joshi, Sangeeta B, Volkin, David B, Richter King, C, Plieskatt, Jordan
Published in Malaria journal (08.11.2019)
Published in Malaria journal (08.11.2019)
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Journal Article
Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody
Toth, Ronald T., Pace, Samantha E., Mills, Brittney J., Joshi, Sangeeta B., Esfandiary, Reza, Middaugh, C. Russell, Weis, David D., Volkin, David B.
Published in Journal of pharmaceutical sciences (01.04.2018)
Published in Journal of pharmaceutical sciences (01.04.2018)
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Journal Article
Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life
Majumdar, Ranajoy, Esfandiary, Reza, Bishop, Steven M, Samra, Hardeep S, Middaugh, C Russell, Volkin, David B, Weis, David D
Published in mAbs (01.01.2015)
Published in mAbs (01.01.2015)
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Journal Article
Improved data visualization techniques for analyzing macromolecule structural changes
Kim, Jae Hyun, Iyer, Vidyashankara, Joshi, Sangeeta B., Volkin, David B., Middaugh, C. Russell
Published in Protein science (01.10.2012)
Published in Protein science (01.10.2012)
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Journal Article
Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants
Bajoria, Sakshi, Kaur, Kawaljit, Kumru, Ozan S., Van Slyke, Greta, Doering, Jennifer, Novak, Hayley, Rodriguez Aponte, Sergio A., Dalvie, Neil C., Naranjo, Christopher A., Johnston, Ryan S., Silverman, Judith Maxwell, Kleanthous, Harry, Love, J. Christopher, Mantis, Nicholas J., Joshi, Sangeeta B., Volkin, David B.
Published in Human vaccines & immunotherapeutics (30.11.2022)
Published in Human vaccines & immunotherapeutics (30.11.2022)
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