GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models
Hanson, Jesse E., Ma, Keran, Elstrott, Justin, Weber, Martin, Saillet, Sandrine, Khan, Abdullah S., Simms, Jeffrey, Liu, Benjamin, Kim, Thomas A., Yu, Gui-Qiu, Chen, Yelin, Wang, Tzu-Ming, Jiang, Zhiyu, Liederer, Bianca M., Deshmukh, Gauri, Solanoy, Hilda, Chan, Connie, Sellers, Benjamin D., Volgraf, Matthew, Schwarz, Jacob B., Hackos, David H., Weimer, Robby M., Sheng, Morgan, Gill, T. Michael, Scearce-Levie, Kimberly, Palop, Jorge J.
Published in Cell reports (Cambridge) (14.01.2020)
Published in Cell reports (Cambridge) (14.01.2020)
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Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors
Kschonsak, Marc, Jao, Christine C, Arthur, Christopher P, Rohou, Alexis L, Bergeron, Philippe, Ortwine, Daniel F, McKerrall, Steven J, Hackos, David H, Deng, Lunbin, Chen, Jun, Li, Tianbo, Dragovich, Peter S, Volgraf, Matthew, Wright, Matthew R, Payandeh, Jian, Ciferri, Claudio, Tellis, John C
Published in eLife (28.03.2023)
Published in eLife (28.03.2023)
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Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor
Gorostiza, Pau, Volgraf, Matthew, Numano, Rika, Szobota, Stephanie, Trauner, Dirk, Isacoff, Ehud Y
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (26.06.2007)
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Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR
Numano, Rika, Szobota, Stephanie, Lau, Albert Y, Gorostiza, Pau, Volgraf, Matthew, Roux, Benoit, Trauner, Dirk, Isacoff, Ehud Y
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2009)
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All Optical Interface for Parallel, Remote, and Spatiotemporal Control of Neuronal Activity
Wang, Sheng, Szobota, Stephanie, Wang, Yuan, Volgraf, Matthew, Liu, Zhaowei, Sun, Cheng, Trauner, Dirk, Isacoff, Ehud Y, Zhang, Xiang
Published in Nano letters (01.12.2007)
Published in Nano letters (01.12.2007)
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A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel
Liu, Chang, Reese, Rebecca, Vu, Simon, Rougé, Lionel, Shields, Shannon D., Kakiuchi-Kiyota, Satoko, Chen, Huifen, Johnson, Kevin, Shi, Yu Patrick, Chernov-Rogan, Tania, Greiner, Demi Maria Zabala, Kohli, Pawan Bir, Hackos, David, Brillantes, Bobby, Tam, Christine, Li, Tianbo, Wang, Jianyong, Safina, Brian, Magnuson, Steve, Volgraf, Matthew, Payandeh, Jian, Zheng, Jie, Rohou, Alexis, Chen, Jun
Published in Neuron (Cambridge, Mass.) (20.01.2021)
Published in Neuron (Cambridge, Mass.) (20.01.2021)
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Engineering Light-Gated Ion Channels
Banghart, Matthew R, Volgraf, Matthew, Trauner, Dirk
Published in Biochemistry (Easton) (26.12.2006)
Published in Biochemistry (Easton) (26.12.2006)
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Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function
Hackos, David H., Lupardus, Patrick J., Grand, Teddy, Chen, Yelin, Wang, Tzu-Ming, Reynen, Paul, Gustafson, Amy, Wallweber, Heidi J.A., Volgraf, Matthew, Sellers, Benjamin D., Schwarz, Jacob B., Paoletti, Pierre, Sheng, Morgan, Zhou, Qiang, Hanson, Jesse E.
Published in Neuron (Cambridge, Mass.) (02.03.2016)
Published in Neuron (Cambridge, Mass.) (02.03.2016)
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Allosteric control of an ionotropic glutamate receptor with an optical switch
Isacoff, Ehud Y, Trauner, Dirk, Volgraf, Matthew, Gorostiza, Pau, Numano, Rika, Kramer, Richard H
Published in Nature chemical biology (01.01.2006)
Published in Nature chemical biology (01.01.2006)
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TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism
Chernov-Rogan, Tania, Gianti, Eleonora, Liu, Chang, Villemure, Elisia, Cridland, Andrew P., Hu, Xiaoyu, Ballini, Elisa, Lange, Wienke, Deisemann, Heike, Li, Tianbo, Ward, Stuart I., Hackos, David H., Magnuson, Steven, Safina, Brian, Klein, Michael L., Volgraf, Matthew, Carnevale, Vincenzo, Chena, Jun
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (17.12.2019)
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Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy
Terrett, Jack A, Chen, Huifen, Shore, Daniel G, Villemure, Elisia, Larouche-Gauthier, Robin, Déry, Martin, Beaumier, Francis, Constantineau-Forget, Léa, Grand-Maître, Chantal, Lépissier, Luce, Ciblat, Stéphane, Sturino, Claudio, Chen, Yong, Hu, Baihua, Lu, Aijun, Wang, Yunli, Cridland, Andrew P, Ward, Stuart I, Hackos, David H, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Balestrini, Alessia, Riol-Blanco, Lorena, Lee, Wyne P, Liu, John, Suto, Eric, Wu, Xiumin, Zhang, Juan, Ly, Justin Q, La, Hank, Johnson, Kevin, Baumgardner, Matt, Chou, Kang-Jye, Rohou, Alexis, Rougé, Lionel, Safina, Brian S, Magnuson, Steven, Volgraf, Matthew
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
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Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation
Dorel, Ruth, Sun, Dawei, Carruthers, Nicholas, Castanedo, Georgette M., Ung, Peter M.-U., Factor, Daniel C., Li, Tianbo, Baumann, Hannah, Janota, Danielle, Pang, Jodie, Salphati, Laurent, Meklemburg, Robert, Korman, Allison J., Harper, Halie E., Stubblefield, Samantha, Payandeh, Jian, McHugh, Daniel, Lang, Bradley T., Tesar, Paul J., Dere, Edward, Masureel, Matthieu, Adams, Drew J., Volgraf, Matthew, Braun, Marie-Gabrielle
Published in Journal of medicinal chemistry (28.03.2024)
Published in Journal of medicinal chemistry (28.03.2024)
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Remote Control of Neuronal Activity with a Light-Gated Glutamate Receptor
Szobota, Stephanie, Gorostiza, Pau, Del Bene, Filippo, Wyart, Claire, Fortin, Doris L., Kolstad, Kathleen D., Tulyathan, Orapim, Volgraf, Matthew, Numano, Rika, Aaron, Holly L., Scott, Ethan K., Kramer, Richard H., Flannery, John, Baier, Herwig, Trauner, Dirk, Isacoff, Ehud Y.
Published in Neuron (Cambridge, Mass.) (24.05.2007)
Published in Neuron (Cambridge, Mass.) (24.05.2007)
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Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design
Volgraf, Matthew, Sellers, Benjamin D, Jiang, Yu, Wu, Guosheng, Ly, Cuong Q, Villemure, Elisia, Pastor, Richard M, Yuen, Po-wai, Lu, Aijun, Luo, Xifeng, Liu, Mingcui, Zhang, Shun, Sun, Liang, Fu, Yuhong, Lupardus, Patrick J, Wallweber, Heidi J.A, Liederer, Bianca M, Deshmukh, Gauri, Plise, Emile, Tay, Suzanne, Reynen, Paul, Herrington, James, Gustafson, Amy, Liu, Yichin, Dirksen, Akim, Dietz, Matthias G. A, Liu, Yanzhou, Wang, Tzu-Ming, Hanson, Jesse E, Hackos, David, Scearce-Levie, Kimberly, Schwarz, Jacob B
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Taking away PAIN: enabling new structures of the Nav1.7 sodium channel by cryo-EM
Jao, Christine, Arthur, Christopher, Rohou, Alexis, Kschonsak, Marc, Ortwine, Daniel, Sellers, Ben, Dragovich, Peter, Volgraf, Matthew, Sutherlin, Dan, Koth, Christopher, Payanden, Jian, Tellis, John, Ciferri, Claudio
Published in Acta crystallographica. Section A, Foundations and advances (30.07.2021)
Published in Acta crystallographica. Section A, Foundations and advances (30.07.2021)
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A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain
Wang, Tzu-Ming, Brown, Brandon M., Deng, Lunbin, Sellers, Benjamin D., Lupardus, Patrick J., Wallweber, Heidi J.A., Gustafson, Amy, Wong, Evera, Volgraf, Matthew, Schwarz, Jacob B., Hackos, David H., Hanson, Jesse E.
Published in Neuropharmacology (15.07.2017)
Published in Neuropharmacology (15.07.2017)
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A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists
Villemure, Elisia, Terrett, Jack A, Larouche-Gauthier, Robin, Déry, Martin, Chen, Huifen, Reese, Rebecca M, Shields, Shannon D, Chen, Jun, Magnuson, Steven, Volgraf, Matthew
Published in ACS medicinal chemistry letters (12.08.2021)
Published in ACS medicinal chemistry letters (12.08.2021)
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Discovery of 5‑Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability
Wang, Xiaojing, Kolesnikov, Aleksandr, Tay, Suzanne, Chan, Grace, Chao, Qi, Do, Steven, Drummond, Jason, Ebens, Allen J, Liu, Ning, Ly, Justin, Harstad, Eric, Hu, Huiyong, Moffat, John, Munugalavadla, Veerendra, Murray, Jeremy, Slaga, Dionysos, Tsui, Vickie, Volgraf, Matthew, Wallweber, Heidi, Chang, Jae H
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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