Discovery of Novel Chemotypes to a G-Protein-Coupled Receptor through Ligand-Steered Homology Modeling and Structure-Based Virtual Screening
Cavasotto, Claudio N, Orry, Andrew J. W, Murgolo, Nicholas J, Czarniecki, Michael F, Kocsi, Sue Ann, Hawes, Brian E, O’Neill, Kim A, Hine, Heather, Burton, Marybeth S, Voigt, Johannes H, Abagyan, Ruben A, Bayne, Marvin L, Monsma, Frederick J
Published in Journal of medicinal chemistry (14.02.2008)
Published in Journal of medicinal chemistry (14.02.2008)
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eCounterscreening: Using QSAR Predictions to Prioritize Testing for Off-Target Activities and Setting the Balance between Benefit and Risk
Sheridan, Robert P, McMasters, Daniel R, Voigt, Johannes H, Wildey, Mary Jo
Published in Journal of chemical information and modeling (23.02.2015)
Published in Journal of chemical information and modeling (23.02.2015)
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Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease
Scott, Jack D, Li, Sarah W, Brunskill, Andrew P. J, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Forman, Mark, Gilbert, Eric J, Hodgson, Robert A, Hyde, Lynn A, Jiang, Qin, Iserloh, Ulrich, Kazakevich, Irina, Kuvelkar, Reshma, Mei, Hong, Meredith, John, Misiaszek, Jeffrey, Orth, Peter, Rossiter, Lana M, Slater, Meagan, Stone, Julie, Strickland, Corey O, Voigt, Johannes H, Wang, Ganfeng, Wang, Hongwu, Wu, Yusheng, Greenlee, William J, Parker, Eric M, Kennedy, Matthew E, Stamford, Andrew W
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
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Journal Article
Potent Inhibition of Grb2 SH2 Domain Binding by Non-Phosphate-Containing Ligands
Yao, Zhu-Jun, King, C. Richter, Cao, Tin, Kelley, James, Milne, George W. A, Voigt, Johannes H, Burke, Terrence R
Published in Journal of medicinal chemistry (14.01.1999)
Published in Journal of medicinal chemistry (14.01.1999)
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Journal Article
Inhibition of Grb2 SH2 Domain Binding by Non-Phosphate-Containing Ligands. 2. 4-(2-Malonyl)phenylalanine as a Potent Phosphotyrosyl Mimetic
Gao, Yang, Luo, Juliet, Yao, Zhu-Jun, Guo, Ribo, Zou, Hong, Kelley, James, Voigt, Johannes H, Yang, Dajun, Burke, Terrence R
Published in Journal of medicinal chemistry (09.03.2000)
Published in Journal of medicinal chemistry (09.03.2000)
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Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors
Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Journal Article
Enhanced CACTVS Browser of the Open NCI Database
Ihlenfeldt, Wolf-Dietrich, Voigt, Johannes H, Bienfait, Bruno, Oellien, Frank, Nicklaus, Marc C
Published in Journal of Chemical Information and Computer Sciences (01.01.2002)
Published in Journal of Chemical Information and Computer Sciences (01.01.2002)
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Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction
Stamford, Andrew W, Scott, Jack D, Li, Sarah W, Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N, Gilbert, Eric J, Huang, Chunli, McKittrick, Brian A, Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H, Kennedy, Matthew E, Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A, Cox, Kathleen, Favreau, Leonard, Parker, Eric M, Greenlee, William J
Published in ACS medicinal chemistry letters (08.11.2012)
Published in ACS medicinal chemistry letters (08.11.2012)
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Journal Article
Cross-Docking of Inhibitors into CDK2 Structures. 1
Duca, José S, Madison, Vincent S, Voigt, Johannes H
Published in Journal of chemical information and modeling (01.03.2008)
Published in Journal of chemical information and modeling (01.03.2008)
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Journal Article
Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins
Baleja, James D., Cherry, Jonathan J., Liu, Zhiguo, Gao, Hua, Nicklaus, Marc C., Voigt, Johannes H., Chen, Jason J., Androphy, Elliot J.
Published in Antiviral research (01.10.2006)
Published in Antiviral research (01.10.2006)
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화합물 및 이의 용도
DENG JING, BRUCELLE FRANCOIS, NETHERTON MATTHEW, VOIGT JOHANNES H, WILSON KEVIN J
Year of Publication 11.01.2024
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Year of Publication 11.01.2024
Patent
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors
Wyss, Daniel F, Wang, Yu-Sen, Eaton, Hugh L, Strickland, Corey, Voigt, Johannes H, Zhu, Zhaoning, Stamford, Andrew W
Published in Topics in current chemistry (01.01.2012)
Published in Topics in current chemistry (01.01.2012)
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PROSIT: Pseudo-Rotational Online Service and Interactive Tool, Applied to a Conformational Survey of Nucleosides and Nucleotides
Sun, Guangyu, Voigt, Johannes H, Filippov, Igor V, Marquez, Victor E, Nicklaus, Marc C
Published in Journal of Chemical Information and Computer Sciences (01.09.2004)
Published in Journal of Chemical Information and Computer Sciences (01.09.2004)
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Cross-Docking of Inhibitors into CDK2 Structures. 2
Voigt, Johannes H, Elkin, Carl, Madison, Vincent S, Duca, José S
Published in Journal of chemical information and modeling (01.03.2008)
Published in Journal of chemical information and modeling (01.03.2008)
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Journal Article
화합물 및 그의 용도
VASWANI RISHI G, HUANG DAVID S, NEGRETTI SOLYMAR, VOIGT JOHANNES H, WILSON KEVIN J, SCHILLER SHAWN E.R
Year of Publication 13.07.2023
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Year of Publication 13.07.2023
Patent
Metal-Dependent Inhibition of HIV-1 Integrase
Neamati, Nouri, Lin, Zhaiwei, Karki, Rajeshri G, Orr, Ann, Cowansage, Kiriana, Strumberg, Dirk, Pais, Godwin C. G, Voigt, Johannes H, Nicklaus, Marc C, Winslow, Heather E, Zhao, He, Turpin, Jim A, Yi, Jizu, Skalka, Anna Marie, Burke, Terrence R, Pommier, Yves
Published in Journal of medicinal chemistry (19.12.2002)
Published in Journal of medicinal chemistry (19.12.2002)
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화합물 및 그의 용도
DENG JING, RUPPEL SABINE K, BRUCELLE FRANCOIS, NETHERTON MATTHEW, VOIGT JOHANNES H, SCHILLER SHAWN E.R, ANTHONY NEVILLE JOHN
Year of Publication 01.11.2022
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Year of Publication 01.11.2022
Patent
2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors
Pissarnitski, Dmitri A., Asberom, Theodros, Bara, Thomas A., Buevich, Alex V., Clader, John W., Greenlee, William J., Guzik, Henry S., Josien, Hubert B., Li, Wei, McEwan, Michael, McKittrick, Brian A., Nechuta, Terry L., Parker, Eric M., Sinning, Lisa, Smith, Elizabeth M., Song, Lixin, Vaccaro, Henry A., Voigt, Johannes H., Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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