HBP/O-GlcNAcylation Metabolic Axis Regulates Bone Resorption Outcome
Taira, T.M., Ramos-Junior, E.S., Melo, P.H., Costa-Silva, C.C., Alteen, M.G., Vocadlo, D.J., Dias, W.B., Cunha, F.Q., Alves-Filho, J.C., Søe, K., Fukada, S.Y.
Published in Journal of dental research (01.04.2023)
Published in Journal of dental research (01.04.2023)
Get full text
Journal Article
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors
Bouquet, J., Auberger, N., Ashmus, R., King, D., Bordes, A., Fontelle, N., Nakagawa, S., Madden, Z., Proceviat, C., Kato, A., Desire, J., Vocadlo, D. J., Bleriot, Y.
Published in Organic & biomolecular chemistry (19.01.2022)
Published in Organic & biomolecular chemistry (19.01.2022)
Get full text
Journal Article
Axonal Transport of Lysosomes Is Unaffected in Glucocerebrosidase-Inhibited iPSC-Derived Forebrain Neurons
Keefe, A. J., Gabrych, D. R., Zhu, Y., Vocadlo, D. J., Silverman, M. A.
Published in eNeuro (01.10.2023)
Published in eNeuro (01.10.2023)
Get full text
Journal Article
Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O -GlcNAcase
Cekic, N, Heinonen, J E, Stubbs, K A, Roth, C, He, Y, Bennet, A J, McEachern, E J, Davies, G J, Vocadlo, D J
Published in Chemical science (Cambridge) (01.01.2016)
Published in Chemical science (Cambridge) (01.01.2016)
Get full text
Journal Article
Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to beta-lactam antibiotics
Bouquet, J., King, D. T., Vadlamani, G., Benzie, G. R., Iorga, B., Ide, D., Adachi, I., Kato, A., Vocadlo, D. J., Mark, B. L., Bleriot, Y., Desire, J.
Published in Organic & biomolecular chemistry (2017)
Published in Organic & biomolecular chemistry (2017)
Get full text
Journal Article
Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate
Withers, Stephen G, Vocadlo, David J, Davies, Gideon J, Laine, Roger
Published in Nature (London) (23.08.2001)
Published in Nature (London) (23.08.2001)
Get full text
Journal Article
Characterization of the Glu and Asp Residues in the Active Site of Human β-Hexosaminidase B
Hou, Yongmin, Vocadlo, David J, Leung, Amy, Withers, Stephen G, Mahuran, Don
Published in Biochemistry (Easton) (20.02.2001)
Published in Biochemistry (Easton) (20.02.2001)
Get full text
Journal Article
Crystallographic Evidence for Substrate-assisted Catalysis in a Bacterial β-Hexosaminidase
Mark, Brian L., Vocadlo, David J., Knapp, Spencer, Triggs-Raine, Barbara L., Withers, Stephen G., James, Michael N.G.
Published in The Journal of biological chemistry (30.03.2001)
Published in The Journal of biological chemistry (30.03.2001)
Get full text
Journal Article
Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state
Williams, Spencer J, Mark, Brian L, Vocadlo, David J, James, Michael N G, Withers, Stephen G
Published in The Journal of biological chemistry (18.10.2002)
Published in The Journal of biological chemistry (18.10.2002)
Get full text
Journal Article
Mechanism of Action and Identification of Asp242 as the Catalytic Nucleophile of Vibrio furnisii N-Acetyl-β-d-glucosaminidase Using 2-Acetamido-2-deoxy-5-fluoro-α-l-idopyranosyl Fluoride
Vocadlo, David J, Mayer, Christoph, He, Shouming, Withers, Stephen G
Published in Biochemistry (Easton) (11.01.2000)
Published in Biochemistry (Easton) (11.01.2000)
Get full text
Journal Article
Crystal Structure of β- d-Xylosidase from Thermoanaerobacterium saccharolyticum, a Family 39 Glycoside Hydrolase
Yang, Jin Kuk, Yoon, Hye-Jin, Ahn, Hyung Jun, Il Lee, Byung, Pedelacq, Jean-Denis, Liong, Elaine C., Berendzen, Joel, Laivenieks, Maris, Vieille, Claire, Zeikus, Gregory J., Vocadlo, David J., Withers, Stephen G., Suh, Se Won
Published in Journal of molecular biology (02.01.2004)
Published in Journal of molecular biology (02.01.2004)
Get full text
Journal Article
Biochemical and Structural Assessment of the 1-N-Azasugar GalNAc-isofagomine as a Potent Family 20 β-N-Acetylhexosaminidase Inhibitor
Mark, Brian L., Vocadlo, David J., Zhao, Dalian, Knapp, Spencer, Withers, Stephen G., James, Michael N.G.
Published in The Journal of biological chemistry (09.11.2001)
Published in The Journal of biological chemistry (09.11.2001)
Get full text
Journal Article
Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and -alkylation leads to low micromolar HexAB and NagZ inhibitors
Bouquet, J, Auberger, N, Ashmus, R, King, D, Bordes, A, Fontelle, N, Nakagawa, S, Madden, Z, Proceviat, C, Kato, A, Désiré, J, Vocadlo, D. J, Blériot, Y
Published in Organic & biomolecular chemistry (19.01.2022)
Published in Organic & biomolecular chemistry (19.01.2022)
Get full text
Journal Article
Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibioticsElectronic supplementary information (ESI) available: Copies of 1H, 19F and 13C spectra of all new compounds; glycosidase assays. See DOI: 10.1039/c7ob00838d
Bouquet, J, King, D. T, Vadlamani, G, Benzie, G. R, Iorga, B, Ide, D, Adachi, I, Kato, A, Vocadlo, D. J, Mark, B. L, Blériot, Y, Désiré, J
Year of Publication 31.05.2017
Year of Publication 31.05.2017
Get full text
Journal Article
Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcaseElectronic supplementary information (ESI) available: Detailed experimental procedures, NMR spectra and additional figures illustrating Ki graphs, kinetic data, pKa titration data and structural analysis data. See DOI: 10.1039/c6sc00370b
Cekic, N, Heinonen, J. E, Stubbs, K. A, Roth, C, He, Y, Bennet, A. J, McEachern, E. J, Davies, G. J, Vocadlo, D. J
Year of Publication 23.05.2016
Year of Publication 23.05.2016
Get full text
Journal Article
Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase† †Electronic supplementary information (ESI) available: Detailed experimental procedures, NMR spectra and additional figures illustrating Ki graphs, kinetic data, pKa titration data and structural analysis data. See DOI: 10.1039/c6sc00370b
Cekic, N., Heinonen, J. E., Stubbs, K. A., Roth, C., He, Y., Bennet, A. J., McEachern, E. J., Davies, G. J., Vocadlo, D. J.
Published in Chemical science (Cambridge) (15.02.2016)
Published in Chemical science (Cambridge) (15.02.2016)
Get full text
Journal Article
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors
Macauley, Matthew S, Whitworth, Garrett E, Debowski, Aleksandra W, Chin, Danielle, Vocadlo, David J
Published in The Journal of biological chemistry (08.07.2005)
Published in The Journal of biological chemistry (08.07.2005)
Get full text
Journal Article